Clinical and radiological characteristics of tumefactive demyelinating lesions: follow-up study

Abstract

Although our demographic data were similar to formerly collected Turkish MS data, we found that the distribution of the patients' clinical course differed if there was an absence of primary progressive MS and that there was a lower frequency of secondary progressive MS cases in our group of patients. We believe that less frequent oligoclonal band positivity and the difference we witnessed in the clinical course of disease in our study groups suggest that there is a need for further studies to compare all the biological and immunological differences between MS and tumefactive lesion cases, in order to reveal whether there are different pathogenetic mechanisms involved.

Clinical and radiological characteristics of 17 Chinese patients with pathology confirmed tumefactive demyelinating diseases: Follow-up study

“…Unlike a previous report [10], no gender predilection was observed in our series, and a median age of 47 years at onset was older than that in most published series [9][10][11][12][13]. Sensory disorder, which is usually one of the most common clinical symptoms in previous studies [9,10,12], was only observed in two cases in our cohort, while other less common presentations including dizziness and brain stem signs (diplopia, dysphagia) were observed in our series.…”

“…Sensory disorder, which is usually one of the most common clinical symptoms in previous studies [9,10,12], was only observed in two cases in our cohort, while other less common presentations including dizziness and brain stem signs (diplopia, dysphagia) were observed in our series. In addition, the frequency of optic neuritis (ON) was a little higher than in previous reports [9][10][11][12].…”

“…Despite several reports [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16], including some large series of tumefactive demyelinating disease [7,9,11,12], no consensus has been reached about this rare spectrum. Common MRI findings include single or multiple large white matter lesions with variable mass effect and edema, complete or open ring enhancement, T2W hypointense rim, and a perilesional restriction on DWI [9][10][11][12][13][14][15][16]. However the prevalence of these radiological features is highly variable, and it is still controversial whether tumefactive CNS IDD represent a variant of MS or a unique form of isolated demyelinating disease.…”

“…Patients with TDLs, often presenting with brain tumor mimicking clinical symptoms and space occupying lesions, have been described in previous reports [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. However, a variety of radiographic and clinical characteristics were reported in different studies; some emphasized the unifocal and clinically isolated features [7,8], while others highlighted the predominant multifocal lesions and a high trend of conversion into multiple sclerosis (MS) by follow-up [9,10].…”

Clinical Cases of Leukoencephalopathy with Predominant Lesion of the Brain Stem, Spinal Cord and High Blood Lactate in the MR Spectroscopy (Mitochondrial Aspartyl-tRNASynthetase Deficiency)

“…При псевдотуморозном течении рассеянного склероза визуализируются контрастно-позитивные очаги демиелинизации, имеющие выраженный перифокаль-ный отек [20,21].…”