Clinical and Radiographic Outcomes of Immature Teeth Treated with Different Treatment Protocols of Regenerative Endodontic Procedures: A Retrospective Cohort Study

Abstract

Regenerative endodontic procedure (REP) is a progressive treatment modality for immature permanent teeth with necrotic pulp. The ambiguousness about the predictability of REP outcome in relation to complete disinfection of the root canal system and the occurrence of discoloration still exists. The aim of this retrospective study was to analyze two treatment protocols on clinical success rate, radiographic root development and the occurrence of discoloration. Eighteen patients were treated by a single operator by either treatment protocol according to the American Association of Endodontists (AAEP, n = 9) or a modified protocol (MP, n = 9) with the use of 5% sodium hypochlorite and sandblasting. Patients were followed up after 3, 6, 9, 12, 18 and 24 months and clinical success, radiographic root development and the occurrence of discoloration were assessed. The clinical success of MP was significantly higher in two years follow-up (p = 0.015), but the change in radiographic root area was higher for AAEP (p = 0.017) and the occurrence of discoloration was higher in AAEP (p = 0.029). The use of 5% sodium hypochlorite for a longer period of time leads to a higher success rate. The sandblasting of the access cavity reduces the occurrence of discoloration.

Ten‐year follow up of previously traumatized immature permanent incisors sustaining second and third traumatic injuries after revascularization treatment: Case reports

“…However, it is known that it depends on complex epithelial-mesenchymal interactions as well as its integration with the surrounding bone, vascular system, and It has been claimed that guided endodontic repair can effectively promote periapical healing and continued root development in previously traumatized immature permanent teeth with pulp necrosis. 13,15,16 Despite an abundance of published case reports and clinical trials reporting regenerative endodontic treatment outcomes in traumatized, necrotic teeth, [16][17][18][19][20] there is little information on how teeth with intracanal repair tissue respond to different types of recurrent trauma. With only one published report of secondary trauma that reported retreatment with a conventional root canal filling 1 year after the initial treatment, 21 the present case series may represent the first long-term data on the fate of traumatized incisors that sustained multiple traumatic injuries after guided endodontic repair.…”

Periodontal Ligament Cells Are Involved in the Formation of Intracanal Cementum-Like Tissue After Regenerative Endodontic Procedures: A Mouse in situ Model

“…The American Association of Endodontists has advocated the clinical use of this therapy, stating "After cleaning and disinfecting the root canal, the apical tissue is intentionally damaged mechanically and bleeding causes a blood clot in the root canal." As a result, the thickness of the root canal wall and narrowing of the root canal space, and continuous root elongation and apical closure are observed radiographically (16,17). Previous case reports showed histological findings of human immature permanent teeth after regenerative endodontics (18)(19)(20)(21).…”