Clinical and radiographic evaluation of 0.8% hyaluronic acid as an adjunct to open flap debridement in the treatment of periodontal intrabony defects: randomized controlled clinical trial

Mamajiwala, Alefiya; Sethi, Kunal Sunder; Raut, Chetan Purushottam; Karde, Prerna Ashok; Mamajiwala, Batul S.

doi:10.1007/s00784-021-03834-7

Cited by 22 publications

(22 citation statements)

References 51 publications

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“…Sci. 2021, 11, 4405 2 of 12 its good tolerability and it ease of use [10], in different fields, including dentistry [11]. In the present work we combined hyaluronic acid with polynucleotides (PN), a mixture of double and single stranded deoxyribonucleotides of animal origin.…”

Section: Introductionmentioning

confidence: 99%

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model

et al. 2021

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Polynucleotides (PN) have long been known as an effective supportive therapy for wound healing. The present study investigated whether a hydrogel formulation containing PN and hyaluronic acid (PN + HA) could promote wound healing in an in vitro model of gingival fibroblasts. PN promoted cell growth and viability as assessed by different assays, and PN + HA, though not significantly further increasing cell growth as compared to PN, supported the formation of dense multilayered cell nodules. PN promoted fibroblasts’ clonogenic efficiency and PN + HA further enhanced the formation of more numerous dense colonies. PN + HA appeared to significantly increase the expression of collagen 1a1 and 3a1, while not affecting proteoglycans deposition. Interestingly, when tested in a scratch assay, PN + HA achieved gap closure after 48 h, while cells in the comparison groups had not completely bridged the scratch even after 96 h. Taken together, these results demonstrate that PN + HA is a promising candidate for a supportive therapy to promote soft tissue healing in the oral cavity.

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Section: Introductionmentioning

confidence: 99%

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model

et al. 2021

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“…Besides the excellent wound-healing abilities of hyaluronic acid, its bacteriostatic activity, biocompatibility, nonimmunogenic property, and safety were confirmed by Becker et al [25] and various other studies [20][21][22][23][24][25][26], suggesting that hyaluronic acid is an ideal adjuvant in periodontal surgical and nonsurgical therapy.…”

Section: Discussionmentioning

confidence: 81%

“…In a recent animal study by Shirakata et al [23], periodontal management of infrabony defects using hyaluronic acid has shown beneficial results. Mamajiwala and coworkers [24] have seen improved clinical and radiographic outcomes using 0.8% hyaluronic acid as an adjunct in treating periodontal infrabony defects by open flap debridement.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Therapeutic Benefits of a Novel Herbal Ingredient-Based Hyaluronic Acid Gel as Monotherapy for Inflammatory Enlargement of a Patient with Diabetes Mellitus

Lanka

Kumar

2022

Case Reports in Dentistry

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The reason for the destruction of the attachment apparatus in patients with periodontal disease is the supra- and the subgingival microflora. Hence, the treatment of this inflammatory gingival disease is primarily focused on eliminating the cause. The present case report assessed the therapeutic benefit of adjunctive use of a commercially available topical agent containing 1% hyaluronic acid gel combined with nonsurgical periodontal therapy. A patient aged 64 years with type 2 diabetes mellitus reported to the Department of Periodontology. He complained of gum enlargement and frequent bleeding during brushing. The patient was not under any medication for his diabetes control. On examination, there was a localized papillary gingival enlargement. Therefore, Klirich gel containing hyaluronic acid was applied on the surface of the gingiva during the first visit of the patient. During the follow-up visit, he continued with this adjunctive use of the gel along with the nonsurgical periodontal therapy. In addition, he controlled his blood sugar level with diet and exercise. During the follow-up visit after one year, there was a noticeable clinical change in the overall health of his gingiva.

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“…The three RCTs [ 19 , 20 , 21 ] included were published between 2013 and 2021 ( Table 2 ). Regarding the type of study, one was a parallel RCT [ 19 ], while two were split-mouth RCTs [ 20 , 21 ]. The studies were conducted in Italy, Brazil, and India.…”

Section: Resultsmentioning

confidence: 99%

“…Mamajiwala et al [ 21 ] recruited patients that received phase I therapy (SRP, oral hygiene instructions). Then, 6 weeks after this therapy, infrabony defects with a PD interproximal ≥ 5 mm were considered for surgery.…”

Section: Resultsmentioning

confidence: 99%

Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

et al. 2022

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Background and objectives: The aim of this systematic review was to assess the electronic literature about the benefits of using hyaluronic acid (HA) in the surgical periodontal treatment of infrabony defects. Materials and methods: This review was conducted under the PRISMA guidelines. The electronic search was conducted on PubMed, Scopus, Web of Science, and Cochrane databases until February 2022. The inclusion criteria consisted of human clinical trials that reported the use of HA in open-flap debridement (OFD) for infrabony defects. The assessment of risk of bias was performed using the Cochrane risk of bias tool. Statistical analysis was performed using Review Manager. Results: Overall, three RCTs were found eligible for the statistical analysis. Probing depth (PD) reduction and clinical attachment level (CAL) gain in the HA test group presented WMs of −1.11 mm (95% CI −2.38 to 0.16 mm; p = 0.09) and −1.38 mm (95% CI −2.26 to −0.49 mm; p = 0.002), respectively. However, the heterogeneity of the RCTs was high, and the risk of bias, in general, was low. Conclusions: The use of hyaluronic acid seems to have beneficial effects in periodontal surgery using OFD, in terms of PD and CAL. To draw a clear conclusion, more adapted and well-designed clinical trials are needed to assess the advantage of this product in comparison with other products.

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Clinical and radiographic evaluation of 0.8% hyaluronic acid as an adjunct to open flap debridement in the treatment of periodontal intrabony defects: randomized controlled clinical trial

Cited by 22 publications

References 51 publications

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model

A Biomimetic Polynucleotides–Hyaluronic Acid Hydrogel Promotes Wound Healing in a Primary Gingival Fibroblast Model

Evaluation of Therapeutic Benefits of a Novel Herbal Ingredient-Based Hyaluronic Acid Gel as Monotherapy for Inflammatory Enlargement of a Patient with Diabetes Mellitus

Efficiency of Hyaluronic Acid in Infrabony Defects: A Systematic Review of Human Clinical Trials

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