Clinical and radiographic evaluation of demineralized freeze-dried bone allograft with concentrated growth factor versus concentrated growth factor alone in the treatment of intrabony defects

Abstract

Background. Periodontal disease is one of the major causes of alveolar bone loss. There are various ways of regenerating the lost bone, i.e. guided tissue regeneration, bone grafts, and growth factors. In this purview, it becomes immensely important for a clinician to decide the best modality of treatment. In this study, we compared the effect of demineralized freeze-dried bone allograft (DFDBA) in combination with concentrated growth factors (CGF) verses CGF alone.
 Methods. This double-blind, split-mouth study was conducted on ten patients with two comparable bilateral intrabony defects. Each pair of defects was randomly treated by DFDBA + CGF or CGF alone. Clinical parameters such as plaque index (PI), modified gingival index (MGI), pocket probing depth (PPD), and relative attachment level (RAL) were recorded at baseline, three months, and six months. In addition, radiograph with grids was also taken at baseline and six months. The paired t-test was used to compare the pre- and post-treatment values and the unpaired t-test was used to compare the test and control group.
 Results. The PI score decreased significantly from baseline to six months. Similarly, the mean MGI score decreased significantly from baseline to six months. The intragroup comparison showed that there was a significant reduction in PPD in both the test and control group. However, the intergroup comparison showed that the reduced pocket depth was not significant. The intragroup radiographic comparison showed that there was the significant formation of bone in both the test and control group but inter-group showed that the formation of bone among both the group were non-significant.
 Conclusion. Radiographic and clinical outcomes of this study concluded that post six months, both groups demonstrated significant improvement in clinical and radiographic parameters. However, the addition of DFDBA to CGFs did not give any additional benefits.

Biphasic Calcium Phosphate Versus Demineralized Freeze-Dried Bone Allograft in the Treatment of Periodontal Disease: A Clinical and Radiographical Evaluation

“…Similarly, the pocket probing depth at sites treated with DFDBA also showed a significant decrease at the end of six months. The current study results align with earlier studies [42][43][44][45][46]. But the sites treated with DFDBA showed a better improvement when compared to the sites treated with BCP.…”

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

“…CGF is mainly composed of concentrated platelets, white blood cells, cytokines, and fibrin with a reticular structure, and is prepared with relation to the coagulation of blood. CGF contains TGF-1, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and insulin-like growth factor-1 (IGF-1), among others (Keranmu et al, 2021;Vaid et al, 2021). The scaffold network structure of CGF slows the release of the growth factors.…”

Clinical application of concentrate growth factors combined with bone substitute in Alveolar ridge preservation of anterior teeth

“…BMP can mediate osteogenesis alone and promote the formation of bone matrix and form calcified bone tissue when mix with other bone growth factors. TGF-β, as an important regulatory factor in the process of bone formation and remodeling, controls inflammation through synthetic fibrous connective tissue and local vascular proliferation, and also induces regeneration of alveolar bone [ 33 ].…”