Clinical and Prognostic Values of ALBI Score in Patients With Acute Heart Failure

Matsue, Yuya; Kagiyama, Nobuyuki; Yamaguchi, Tetsuo; Kuroda, Shunsuke; Okumura, Takahiro; Kida, Kenji; Mizuno, Atsushi; Oishi, Shogo; Inuzuka, Yasutaka; Akiyama, Eiichi; Matsukawa, Ryuichi; Kato, Kota; Suzuki, Satoshi; Naruke, Tsuguo; Yamagata, Kenji; Miyoshi, Tatsuya; Baba, Yuichi; Yamamoto, Masayoshi; Mizutani, Kazuo; Yoshida, Kazuki; Kitai, Takeshi

doi:10.1016/j.hlc.2019.12.003

Cited by 31 publications

(31 citation statements)

References 29 publications

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“…The scoring systems that can predict adverse outcomes included total bilirubin levels (e.g., Model for End-Stage Liver Dysfunction series score [MELD], MELDIX, and ALBI score). [19][20][21] However, the clinical and prognostic value of AST and ALT were not sufficient in AHF. A multi-organ dysfunction/injury scoring system that includes AST/ALT has been suggested, and a scoring sys- Adjusting factors for FIB4 index, platelet, AST and ALT, gender (male), heart rate (per 10-bpm increase), ischemic heart disease (yes), total bilirubin (per 0.1-mg/dL increase), sodium (per 1.0 mEg/L increase), potassium (per 1.0 mEq/L increase), creatinine (per 0.1-mg/dL increase), LVEF (per 10% increase), systolic blood pressure (per 10-mmHg increase), blood urea nitrogen (per 1.0-mg/dL increase), re-hospitalization (yes).…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of the Fibrosis-4 Index in Patients with Acute Heart Failure Requiring Intensive Care

et al. 2021

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The Fibrosis-4 (FIB4) index could indicate the liver fibrosis in patients with chronic hepatic diseases. It was calculated using the following formula: (age × aspartate aminotransferase [U/L]) / (platelet count [10 3 /μL] × alanine aminotransferase [U/L]). However, the clinical impact of the FIB4 index in the acute phase of acute heart failure (AHF) has not been sufficiently investigated.A total 1,468 AHF patients were analyzed. The median FIB4 index was 2.71 [1.85-4.22]. The patients were divided into three groups according to the quartiles of their FIB4 index (low-FIB4 [Q1, !1.847], middle-FIB4 [Q2/Q3, 1.848-4.216], and high-FIB4 [Q4, "4.216] groups). A Kaplan-Meier curve analysis showed that the prognosis, such as all-cause mortality and HF events within 365 days, was significantly poorer in the high-FIB4 group than in the middle-FIB4 and low-FIB4 groups. A multivariate Cox regression model identified high FIB4 index as an independent predictor of 365-day all-cause death (hazard ratio (HR): 1.660, 95% CI: 1.136-2.427) and HF events (HR: 1.505, 95% CI: 1.145-1.978). The multivariate logistic regression analysis showed that the high plasma volume status (PVS) (Q4, odds ratio [OR]: 2.099, 95% CI: 1.429-3.082), low systolic blood pressure (SBP) (< 100 mmHg, OR: 3.825, 95% CI: 2.504-5.840), and low left ventricular ejection fraction (< 40%, OR: 1.321, 95% CI: 1.002-1.741) were associated with a high FIB4 index.A high FIB4 index can predict adverse outcomes in AHF patients, which indicate that congestive liver and liver hypoperfusion occur due to low cardiac output in the acute phase of AHF.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of the Fibrosis-4 Index in Patients with Acute Heart Failure Requiring Intensive Care

et al. 2021

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“…2.25 and > 2.25) based on the mean ALBI score of a previous study that reported the characteristics of the enrolled patients. 14) In addition, to investigate the relationship between ALBI grade and in-hospital mortality, patients were classified 3 ALBI grades (! 2.60 = grade 1, > 2.60 to !…”

Section: Study Subjects and Protocolmentioning

confidence: 99%

“…12,13) Therefore, the ALBI score, as a combined measurement of albumin and total bilirubin, may become a more attractive prognostic index in patients with HF, and not only in patients with hepatocellular carcinoma. However, to date, a study 14) which showed an association between ALBI score and one-year mortality after discharge in patients hospitalized for acute HF, remains the only report of ALBI score and HF. In the present study, we hypothesized that the ALBI score at admission is associated with in-hospital mortality in patients hospitalized for acute HF.…”

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confidence: 99%

Association Between Albumin-Bilirubin Score at Admission and In-Hospital Mortality in Patients with Acute Heart Failure

Kawata¹,

Ikeda²,

Masuda³

et al. 2021

Int. Heart J.

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Liver dysfunction is one of the most recognized complications in patients with acute heart failure (HF) and therefore a liver function score may be useful for risk-stratification in those patients. Recently, the albuminbilirubin (ALBI) score was developed as a new model to assess liver function in liver disease. We explored the association between the ALBI score at admission and in-hospital mortality in patients with acute HF.We enrolled 262 patients (median age, 86 years, 137 males) who were admitted to our hospital for treatment of acute HF. The following data were recorded: vital signs, laboratory data including B-type natriuretic peptide (BNP) level, echocardiographic data at admission, demographic and clinical characteristics, and treatment and prognostic information. The Get With the Guidelines-Heart Failure (GWTG-HF) risk score was calculated as an established risk model for each patient. The primary outcome was all-cause in-hospital mortality.During hospitalization, 37 patients (14.1%) died. The in-hospital mortality rate was significantly higher in patients with ALBI scores > 2.25 compared with patients with ALBI scores ! 2.25 (21.1% versus 4.5%, respectively; P = 0.0001). Multivariate analysis revealed that the GWTG-HF score (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.08-1.25, P < 0.0001), BNP level (OR 1.0007, 95% CI 1.0003-1.001, P = 0.0003) and ALBI score (OR 6.0, 95% CI 1.8-19.6, P = 0.0017) were independently associated with in-hospital mortality.Our results indicated that the ALBI score was independently associated with in-hospital mortality in patients hospitalized for acute HF.

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“…Therefore, the ALBI score might be suitable for assessing the severity of cardio-hepatic 2 of 11 syndrome and subsequent prognosis. It has been demonstrated that high ALBI scores are associated with fluid overload and subsequent poor prognosis in HF patients [8]. Thus, we hypothesized that a response to CRT results in improved liver function and subsequent favorable outcomes in HF patients with a high ALBI score before CRT.…”

Section: Introductionmentioning

confidence: 98%

Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy

Yamada

Kaneshiro

Yoshihisa

et al. 2021

JCM

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Background: Liver function may be a useful indicator of response to cardiac resynchronization therapy (CRT). We aimed to investigate the clinical significance of albumin-bilirubin (ALBI) score, an assessment tool of liver function, on outcomes in heart failure (HF) patients treated with CRT. Methods: We studied 180 patients undergoing CRT. The ALBI score, derived from albumin and total bilirubin, and left ventricular ejection fraction (LVEF) were assessed before and 6 months after CRT. The patients were classified according to the ALBI score before CRT; High (>−2.60) or Low (≤−2.60) ALBI groups. The patients were then reclassified based on the ALBI score before and 6 months after CRT; High/High, High/Low, Low/High, and Low/Low ALBI groups. We evaluated the prognostic value of the ALBI score for HF deaths after CRT. Results: During a median follow-up period of 50 months, there were 41 (22.7%) HF deaths. A Cox proportional hazard analysis revealed that high ALBI scores at baseline were not related to HF deaths (hazard ratio, 1.907, p = 0.068). However, High/High ALBI scores, but not High/Low or Low/High ALBI scores, were an independent predictor of HF deaths compared with Low/Low ALBI scores (hazard ratio, 3.449, p = 0.008), implying that consistently high ALBI scores were associated with poor prognosis. The percentage change in LVEF from baseline to 6 months after CRT did not differ among the four groups, suggesting that left ventricular systolic function was not linked with the ALBI score. Conclusions: ALBI scores before and after CRT are a new indicator of CRT response, and have a predictive value for HF deaths in HF patients.

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Clinical and Prognostic Values of ALBI Score in Patients With Acute Heart Failure

Cited by 31 publications

References 29 publications

Clinical Significance of the Fibrosis-4 Index in Patients with Acute Heart Failure Requiring Intensive Care

Clinical Significance of the Fibrosis-4 Index in Patients with Acute Heart Failure Requiring Intensive Care

Association Between Albumin-Bilirubin Score at Admission and In-Hospital Mortality in Patients with Acute Heart Failure

Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy

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