Albumin-Bilirubin Score for Prediction of Outcomes in Heart Failure Patients Treated with Cardiac Resynchronization Therapy

Abstract

Background: Liver function may be a useful indicator of response to cardiac resynchronization therapy (CRT). We aimed to investigate the clinical significance of albumin-bilirubin (ALBI) score, an assessment tool of liver function, on outcomes in heart failure (HF) patients treated with CRT. Methods: We studied 180 patients undergoing CRT. The ALBI score, derived from albumin and total bilirubin, and left ventricular ejection fraction (LVEF) were assessed before and 6 months after CRT. The patients were classified according to the ALBI score before CRT; High (>−2.60) or Low (≤−2.60) ALBI groups. The patients were then reclassified based on the ALBI score before and 6 months after CRT; High/High, High/Low, Low/High, and Low/Low ALBI groups. We evaluated the prognostic value of the ALBI score for HF deaths after CRT. Results: During a median follow-up period of 50 months, there were 41 (22.7%) HF deaths. A Cox proportional hazard analysis revealed that high ALBI scores at baseline were not related to HF deaths (hazard ratio, 1.907, p = 0.068). However, High/High ALBI scores, but not High/Low or Low/High ALBI scores, were an independent predictor of HF deaths compared with Low/Low ALBI scores (hazard ratio, 3.449, p = 0.008), implying that consistently high ALBI scores were associated with poor prognosis. The percentage change in LVEF from baseline to 6 months after CRT did not differ among the four groups, suggesting that left ventricular systolic function was not linked with the ALBI score. Conclusions: ALBI scores before and after CRT are a new indicator of CRT response, and have a predictive value for HF deaths in HF patients.

Neutrophil-to-Lymphocyte Ratio Can Distinguish Patients with Liver Cirrhosis from Healthy People but Cannot Distinguish Patients with Cirrhotic Hepatocellular Carcinoma from Patients with Liver Cirrhosis

“…The ALBI score, a score calculated from the patient’s serum albumin and total bilirubin, was proposed for assessing liver function and subsequent long-term mortality in patients with liver disease. 28 As a simple, evidence-based, objective marker of assessing liver function, ALBI score has been applied in other diseases such as heart failure, lung cancer. 29 , 30 According to ALBI score in this study, liver functions of LC patients were worst among different populations.…”

Clinical Data, Chest Radiograph and Electrocardiography in the Screening for Left Ventricular Hypertrophy: The CAR2E2 Score

“…There is increasing interest in the use of markers and risk scores as well as in testing their clinical applicability in cardiovascular medicine [25][26][27][28][29][30][31][32][33]. Several factors have been found to be associated with LVH assessed by different modalities [7,16].…”

The ALBI score: From liver function in patients with HCC to a general measure of liver function

“… Yamada et al. 139 Retrospective 180 Heart failure ALBI score had a predictive value for death from heart failure in patients who underwent cardiac resynchronisation therapy. Han et al.…”

“…There have been several reports that the ALBI score is prognostic in certain non-hepatological conditions including acute or chronic heart failure (short-term and long-term prognosis), [138] , [139] , [140] , [141] , [142] , [143] acute pancreatitis 144 and aortic dissection. In some conditions the prognostic value is remarkably high.…”