Clinical and pathological heterogeneity in a series of 31 patients with IgM-related neuropathy

Luigetti, Marco; Conte, Amelia; Montano, Nicola; Grande, Alessandra Del; Madia, Francesca; Monaco, Mauro Lo; Laurenti, Luca; Sabatelli, Mario

doi:10.1016/j.jns.2012.05.012

Cited by 18 publications

(22 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, sural nerve biopsies cause sensory loss and, in some cases, chronic neuropathic pain. It has been reported that some patients with IgM related neuropathy have small fiber neuropathy [25,26]. We did not find that patients with immunoglobulin deposition were more likely to have a painful neuropathy than patients without deposition, so painful neuropathy is not a hallmark of immunoglobulin deposition.…”

Section: Discussioncontrasting

confidence: 71%

“…The previous studies examined both sural nerve biopsies and skin biopsies and it is possible that sural nerve biopsies are more sensitive than skin biopsies. Further, it has been reported that sural nerve biopsies could help clarify disease mechanism and possibly identify patients that might benefit from immunosuppressive therapy [25,26]. However, sural nerve biopsies cause sensory loss and, in some cases, chronic neuropathic pain.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunostaining of skin biopsy adds no diagnostic value in MGUS-associated peripheral neuropathy

Al‐Zuhairy

Plesner

Abildgaard

et al. 2015

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Immunostaining of skin biopsy adds no diagnostic value in MGUS-associated peripheral neuropathy

Al‐Zuhairy

Plesner

Abildgaard

et al. 2015

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…In conclusion, also in anti‐MAG neuropathy nerve US is confirmed to be an important complementary tool that might help a correct diagnosis to be reached especially in the most difficult or less defined cases . Further prospective studies may clarify the evolution of US changes according to history, neurophysiology and therapeutic response.…”

Section: Discussionmentioning

confidence: 75%

Nerve ultrasound findings in neuropathy associated with anti‐myelin‐associated glycoprotein antibodies

Lucchetta

Padua

Granata

et al. 2014

Euro J of Neurology

Self Cite

View full text Add to dashboard Cite

show abstract

“…An emerging body of evidence indicates that small fiber involvement and early axonal involvement is present in CIDP 19, 20. As such, CCM may be a useful measure of nerve damage in patients with CIDP.…”

Section: Introductionmentioning

confidence: 99%

Corneal confocal microscopy in chronic inflammatory demyelinating polyneuropathy

Stettner

Hinrichs

Guthoff

et al. 2015

Ann Clin Transl Neurol

105

View full text Add to dashboard Cite

ObjectiveThere is an unmet need for better diagnostic tools to further delineate clinical subsets of heterogeneous chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) to facilitate treatment decisions. Corneal confocal microscopy (CCM) is a noninvasive and reproducible nerve imaging technique. This study evaluates the potential of CCM as a diagnostic surrogate in CIDP and MMN.MethodsIn a cross‐sectional prospective approach, 182 patients and healthy controls were studied using CCM to quantify corneal nerve damage and immune cell infiltration.ResultsPatients with CIDP and MMN had a reduction in corneal nerve fiber (CNF) measures and an increase in corneal immune cell infiltrates. In CIDP, CNF parameters decreased with increasing duration of disease. The number of dendritic cells in proximity to CNFs was increased in patients with early disease and correlated with the degree of motor affection. A further reduction in CNF parameters and an increase in nondendritic cells were observed in patients with painful neuropathy. In CIDP patients with antineuronal antibodies the number of nondendritic cells was increased.InterpretationOur findings suggest that CNF loss may reflect severity of neuropathy and quantification of distinct cells around the CNF plexus may help in stratifying CIDP subtypes, clinical course, and disease activity. However, further longitudinal studies are required before CCM can be considered as a valid surrogate endpoint for patients with CIDP and MMN.

show abstract

Clinical and pathological heterogeneity in a series of 31 patients with IgM-related neuropathy

Cited by 18 publications

References 24 publications

Immunostaining of skin biopsy adds no diagnostic value in MGUS-associated peripheral neuropathy

Immunostaining of skin biopsy adds no diagnostic value in MGUS-associated peripheral neuropathy

Nerve ultrasound findings in neuropathy associated with anti‐myelin‐associated glycoprotein antibodies

Corneal confocal microscopy in chronic inflammatory demyelinating polyneuropathy

Contact Info

Product

Resources

About