Clinical and parasitological evaluation of dogs naturally infected by Leishmania (Leishmania) chagasi submitted to treatment with meglumine antimoniate

Ikeda-Garcia, Fabiana Augusta; Lopes, Raimundo Souza; Marques, Fábia Judice; Lima, Valéria Marçal Felix de; Morinishi, Celina Kazue; Bonello, F. L.; Zanette, Maurício Franco; Perri, Sílvia Helena Venturoli; Feitosa, Mary Marcondes

doi:10.1016/j.vetpar.2006.08.019

Cited by 55 publications

(40 citation statements)

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“…(Ikeda-Garcia et al, 2003;Nelson & Couto, 2015). Este aumento celular na corrente sanguínea corrobora com Ikeda-Garcia et al (2008), que referiram que o aumento do número de monócitos e macrófagos é muito frequente em cães com leishmaniose visceral.…”

Section: Resultsunclassified

“…A ocorrência de alterações no sangue em cães com leishmaniose visceral é importante para auxiliar no diagnóstico da doença em áreas endêmicas. As alterações mais frequentemente relatadas são em relação ao eritrograma, que apresenta anemia, geralmente normocítica e normocrômica nos animais infectados (Ikeda-Garcia et al, 2003;Ikeda-Garcia et al, 2008). Embora a leishmaniose visceral canina seja uma doença bastante relatada, há poucos estudos referentes ao perfil hematológico de cães portadores da doença.…”

Section: Introductionunclassified

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Hematological abnormalities in dogs naturally infected by Leishmania spp

Braz

Sartoretto

Souza

et al. 2015

AVB

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Section: Resultsunclassified

Section: Introductionunclassified

Hematological abnormalities in dogs naturally infected by Leishmania spp

Braz

Sartoretto

Souza

et al. 2015

AVB

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“…In cases of chronic inflammation, all medullary granulocyte compartments are increased, as well as bone marrow cellularity (REBAR, 1993;IKEDA-GARCIA et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of bone marrow in pancytopenic dogs

Girardi

Campos

Pescador

et al. 2017

SCA

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The pancytopenia can be associated with intra and extra medullary disorders. When the etiology is not obvious, the examination of bone marrow is necessary. The study aims to report and discuss quantitative amendments in bone marrow and their causes in dogs with pancytopenia. Bone marrow aspirate was obtained from 65 dogs with pancytopenia over a period of 13 consecutive months for preparation of smears stained by Giemsa and observed in light microscopy. Five hundred cells differential count was held; and assessed myeloid:erythroid ratio, cellularity, megakaryocytes and direct parasitological examination. The data were evaluated by the Chi-square statistical test. Blood tests of 3120 canines with several clinical changes were analyzed to identify pancytopenia, which accounted for 167 (5.4%) dogs. Interpretation of quantitative characteristics was carried out from the bone marrow smear in 65 pancytopenic dogs and the etiology was established in 40 (61.5%) of these, which included infection by E. canis and L. chagasi, idiopathic aplastic anemia, chronic renal failure and co-infections. In 17 (26.2%) animals were not observed medullary changes. The most bone marrow change was observed myeloid and erythroid hypoplasia in 17 (26.2%) dogs, followed by myeloid and erythroid hyperplasia (24.6%). The myelogram association to the blood cell count allowed the identification of medullary findings and its participation on the occurrence of pancytopenia cases. The number of cases resulting from infectious diseases was 38 (58.5%) in canine assessed: significant number due to its endemic characteristic of the study region. Key words: Cytology. Canine. Cytopenia. Hemoparasites. Myelogram. ResumoA pancitopenia pode estar associada a distúrbios intra e extra medulares. Quando a etiologia não é óbvia, o exame da medula óssea é necessário. Este estudo tem como objetivo relatar e discutir alterações quantitativas na medula óssea e suas causas em cães com pancitopenia. De 65 cães pancitopêncicos atendidos durante um período de 13 meses consecutivos, foram realizados aspirados de medula óssea, corados com Giemsa, e observados em microscopia de luz. Quinhentas células foram observadas para contagem diferencial, razão mieloide: eritróide, celularidade, megacariócitos e exame parasitológico direto. Os dados foram avaliados pelo teste estatístico Qui-quadrado. Hemograma de 3120 caninos com diversas alterações clínicas foram analisadas para identificar a pancitopenia, encontrada em 167 (5,4%) cães. A interpretação das características quantitativas foi realizada a partir do esfregaço de medula óssea em 65 cães pancitotopênicos e a etiologia foi estabelecida em 40 (61,5%), incluindo infecção por

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“…Information from other studies that used bone marrow aspiration showed that there was no sterile cure in most treated dogs, despite clinical improvement. 14,15,21,27 Thus, the possibility of relapse as an epidemiologic risk 28,29 still exists in disease-free survivor dogs, although to a lesser extent. For this reason, it has been recommended to use preventative measures against parasite transmission in animals and to monitor them on a regular basis to assess future clinical relapse.…”

Section: Discussionmentioning

confidence: 99%