Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type

Abstract

The otolaryngologist plays a fundamental role in the prognosis of NKTLN and can shorten time between symptom onset and treatment of the patient.

Differential Diagnosis of Necrotizing Sinonasal Lesions

“…[30][31][32][33][34] Other names for this lymphoid neoplasm include lethal midline granuloma, polymorphic reticulosis, and midline malignant reticulosis, although the preferred terminology currently is extranodal NK/T-cell lymphoma, nasal type. These tumors are more commonly seen in males and most commonly seen in Asia as well as Central and South America.…”

“…These tumors are more commonly seen in males and most commonly seen in Asia as well as Central and South America. [30][31][32][33][34] The diagnosis is often difficult to make and is especially challenging early in the disease because patients initially present with nonspecific symptoms including nasal discharge, sinusitis, and headaches. Over time, the lesion becomes more destructive with extensive mucosal ulceration and destruction of bone and cartilage.…”

“…The lesional cells are positive for CD56, a marker for NK cell differentiation; CD2; CD3e; CD7; and CD8, and are often negative for CD3, CD5, CD16, and CD57. [30][31][32][33][34] The NK/T-cell lymphomas often express TIA-1, granzyme, perforin, and FAS. Epstein-Barr virus is almost always identified in lesional cells.…”

Apnea obstructiva del sueño y linfoma extraganglionar de célula T/NK tipo nasal

“…Los síntomas son inespecíficos e incluyen rinorrea, obstrucción nasal y epistaxis 2 , por lo que inicialmente estos casos son vistos en otorrinolaringología. El diagnóstico suele retrasarse por múltiples biopsias con muestra insuficiente o áreas de necrosis, y el tratamiento incluye radioterapia y quimioterapia 2,3 .…”

Accurate Diagnose and management of advanced nasal type extranodal NK/T cell lymphoma. A case Report.

“…Extranodal natural killer/T-cell lymphoma, nasal type (NKTL), was the term endorsed by the Revised European American Lymphoma Classification (REAL) in 2008 (1) to refer to what was previously known as malign granuloma or polymorphic malignant reticulosis. This lymphoma is one of the most lethal midline granulomas, which are characterized for the extensive destructive lesions in the mucosa of the superior airway and middle facial third (1,2).…”