Clinical and neuropathological evolution of the hydrocephalus developed by the mutant mouse hyh

Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection

“…In addition, a recent exome sequencing of 381 infants with congenital hydrocephalus identified a predominance of de novo mutations in genes associated with neural stem cell differentiation (Jin et al, 2020). Experimentally, a series of studies on hyh mice (Jimenez et al, 2009;Batiz et al, 2005Batiz et al, , 2006Perez-Figares et al, 1998;Wagner et al, 2003) that develop perinatal aqueductal stenosis also support the concept of a defect in cell junction complexes as an underlying cause of hydrocephalus. Although our use of NPIH as controls focused on the acute inflammatory responses that lead to PIH, there are linkages to common mechanisms in other forms of infant hydrocephalus.…”

“…Article fighting infection and clearing microbial pathogens, prolonged or overstimulated immune activation may be detrimental (Tchessalova et al, 2018); indeed, recent evidence from both experimental (Guerra et al, 2015a;Ortloff et al, 2013;Rodriguez et al, 2012;Jimenez et al, 2009;Paez et al, 2007;Batiz et al, 2005) and clinical (Ortega et al, 2016;Guerra et al, 2015a;Sival et al, 2011) studies demonstrates that host immune response associated with ependymal cell-cell junction protein disruption is a critical pathogenetic mechanism of hydrocephalus.…”