Pathophysiology of congenital and neonatal hydrocephalus

McAllister, James P.

doi:10.1016/j.siny.2012.06.004

Cited by 159 publications

(148 citation statements)

References 83 publications

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“…[22][23][24][25]27,57,79,80,136 Metabolic disturbances contribute to reversible dysfunction, but the clinical syndrome of hydrocephalic brain dysfunction may be due predominantly to a subcortical disconnection syndrome. Possible causes of ventricular dilation include obstructed CSF flow with associated increased CSF pulsatility.…”

Section: Pathophysiological Modificationsmentioning

confidence: 99%

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

McAllister

Williams

Walker

et al. 2015

JNS

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abbreviatioNs CPC = choroid plexus cauterization; DTI = diffusion tensor imaging; ETV = endoscopic third ventriculostomy; HCRN = Hydrocephalus Clinical Research Network; ICP = intracranial pressure; iNPH = idiopathic NPH; LPA = lysophosphatidic acid; NIH = National Institutes of Health; NPC = neural precursor cell; NPH = normal pressure hydrocephalus; NSC = neural stem cell; PreOL = precursor oligodendroglia; RCT = randomized controlled trial; SVZ = subventricular zone; TNF = tumor necrosis factor; VP = ventriculoperitoneal; VZ = ventricular zone. . International experts gave plenary talks, and extensive group discussions were held for each of the major themes.The conference emphasized patient-centered care and translational research, with the main objective to arrive at a consensus on priorities in hydrocephalus that have the potential to impact patient care in the next 5 years. The current state of hydrocephalus research and treatment was presented, and the following priorities for research were recommended for each theme. 1) Causes of Hydrocephalus-CSF absorption, production, and related drug therapies; pathogenesis of human hydrocephalus; improved animal and in vitro models of hydrocephalus; developmental and macromolecular transport mechanisms; biomechanical changes in hydrocephalus; and age-dependent mechanisms in the development of hydrocephalus. 2) Diagnosis of Hydrocephalus-implementation of a standardized set of protocols and a shared repository of technical information; prospective studies of multimodal techniques including MRI and CSF biomarkers to test potential pharmacological treatments; and quantitative and cost-effective CSF assessment techniques. 3) Treatment of Hydrocephalus-improved bioengineering efforts to reduce proximal catheter and overall shunt failure; external or implantable diagnostics and support for the biological infrastructure research that informs these efforts; and evidencebased surgical standardization with longitudinal metrics to validate or refute implemented practices, procedures, or tests. 4) Outcome in Hydrocephalus-development of specific, reliable batteries with metrics focused on the hydrocephalic 1427

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Section: Pathophysiological Modificationsmentioning

confidence: 99%

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

McAllister

Williams

Walker

et al. 2015

JNS

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“…According to the gender distribution, several studies identify slight male predominance for Congenital Hydrocephalus 1,15 being limited in fetal period 3,6,9,[15][16][17] , being this case report in the findings. observed temporary improvement due to worsening of neurological symptoms, however, it is noteworthy that this action is very important in order to minimize sequelae and / or maintain oral functions, focusing RESUMO A Hidrocefalia é definida como um transtorno na hidrodinâmica liquórica, com aumento do seu volume no compartimento intracraniano, da dilatação ventricular e da pressão intracraniana.…”

Section: Discussionmentioning

confidence: 80%

Atuação fonoaudiológica na hidrocefalia congênita com derivação ventrículo peritoneal: relato de caso

2015

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Resumo:A Hidrocefalia é definida como um transtorno na hidrodinâmica liquórica, com aumento do seu volume no compartimento intracraniano, da dilatação ventricular e da pressão intracraniana. O tratamento da hidrocefalia é feito com uso de válvulas de derivação periventricular (shunt). Se não for tratada, a criança com hidrocefalia poderá apresentar macrocefalia, retardo do desenvolvimento neuropsicomotor, infecções, meningites, dificuldades para aprender e alimentar-se (disfagia). Este estudo busca relatar as principais alterações fonoaudiológicas encontradas em um indivíduo diagnosticado com hidrocefalia congênita, tratada tardiamente com derivação ventrículo peritoneal. Trata-se de um estudo retrospectivo, descritivo dos dados contidos no prontuário. O paciente apresentou alterações de órgãos fonoarticulatórios, sialorréia, apertamento mandibular e Disfagia Orofaríngea Neurogênica de grau Moderado/Severo. Foram realizados exercícios de estimulação profunda, crioterapia, pontos motores da face, manobras facilitadoras da deglutição e correção postural durante a oferta de via oral. A literatura para atuação fonoaudiológica na hidrocefalia é escassa, porém, com este relato de caso, foi possível relatar as principais alterações fonoaudiológicas e intervenções terapêuticas encontradas na Hidrocefalia Congênita.

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“…Ventriculomegaly is the most common brain anomaly found on prenatal ultrasound scans [1,2], with an incidence of approximately 0.3-1.5 cases per 1,000 live births [3,4,5,6]. Mean ventricular width on prenatal ultrasound at 20-40 weeks of gestation has been reported as 6.4 mm (SD: 1.2 mm) measured at the level of the atrium [7].…”

Section: Introductionmentioning

confidence: 99%

Correlating Prenatal Imaging Findings of Fetal Ventriculomegaly with the Need for Surgical Intervention in the First 3 Months after Birth

Johnson²,

Kerr³

et al. 2016

Pediatr Neurosurg

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Background/Aims: This study evaluates the predictive value of prenatal imaging measurements regarding the need for cerebrospinal fluid (CSF) diversion for fetal hydrocephalus in the first 3 months after birth. Methods: We retrospectively reviewed a consecutive case series of patients with fetal hydrocephalus from January 2011 to December 2014 (n = 45). Prenatal measurements included head circumference (HC), biparietal diameter (BPD), and lateral ventricle (LV) width. Patients requiring CSF diversion within 12 weeks of birth were compared to those who did not require CSF diversion using the Wilcoxon rank sum test, and receiver-operating characteristic analysis was used to evaluate threshold values. Results: CSF diversion was required within 12 weeks of birth in 30 of 45 patients. Mean LV width (mm) during the entire pregnancy was greater for the surgery group than the nonsurgery group. Neither BPD nor HC showed differences between the groups. A mean LV size ≥15 mm predicted the need for CSF diversion with a sensitivity of 67% and specificity of 73%. Conclusion: LV width is the prenatal imaging measurement that best predicts the need for postnatal CSF diversion.

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Pathophysiology of congenital and neonatal hydrocephalus

Cited by 159 publications

References 83 publications

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

Atuação fonoaudiológica na hidrocefalia congênita com derivação ventrículo peritoneal: relato de caso

Correlating Prenatal Imaging Findings of Fetal Ventriculomegaly with the Need for Surgical Intervention in the First 3 Months after Birth

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