Clinical and microbiological observations on CDC group DF-3, a gram-negative coccobacillus

Gill, Vee J.; Travis, Lois B.; Williams, Denise

doi:10.1128/jcm.29.8.1589-1592.1991

Cited by 12 publications

(7 citation statements)

References 4 publications

(3 reference statements)

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“…DF‐3 microorganisms are particularly resistant to antimicrobials, and almost uniform resistance has been described to aminoglycosides, quinolones and all β‐lactams, except for imipenem, which showed variable activity [6,7]. In our case both imipenem and meropenem showed MICs >32 mg/L by E‐test (AB Biodisk.…”

Section: Biochemical Characteristics Of Our Isolatementioning

confidence: 66%

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Clinical isolation of a DF-3 microorganism and review of the literature

Martínez-Sánchez

Vasallo

Garcı́a-Garrote

et al. 1998

Clinical Microbiology and Infection

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Section: Biochemical Characteristics Of Our Isolatementioning

confidence: 66%

“…DF‐3 has recently been associated with human disease, mainly chronic diarrhea [6–9]. We were able to find 10 cases of diarrhea purportedly caused by DF‐3.…”

Section: Biochemical Characteristics Of Our Isolatementioning

confidence: 96%

Clinical isolation of a DF-3 microorganism and review of the literature

Martínez-Sánchez

Vasallo

Garcı́a-Garrote

et al. 1998

Clinical Microbiology and Infection

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“…While cases of C. canimorsus bacteremia in patients with the predisposing factors of alcoholism, splenectomy, and chronic lung disorders (26,49,144,197,263,266,283) and in otherwise healthy individuals (41,49,109,144,283,332) continue to be reported, a number of reports indicate that cancer should be considered a risk factor as well. Table 3 lists the cases of Capnocytophaga bacteremia associated with underlying neoplasia that have been reported (6,9,102,105,110,118,119,137,138,144,146,197,216,224,235,243,269,315,316,325). The association with hematologic malignancies, leukemia and lymphoma, is amply demonstrated.…”

Section: Capnocytophaga Sppmentioning

confidence: 99%

“…Hickling et al (144) reviewed 41 cases of DF-2 infection and noted five cases of cancer: three cases of Hodgkin's disease and two cases of chronic lymphocytic leukemia. There appears to The unnamed Capnocytophaga species called DF-3 has been shown in some studies (25,118,311) to be associated with gastrointestinal disease. Gill et al (118) showed that 1.6% (11 of 690 cultures) of stool cultures were positive for DF-3.…”

Section: Capnocytophaga Sppmentioning

confidence: 99%

“…There appears to The unnamed Capnocytophaga species called DF-3 has been shown in some studies (25,118,311) to be associated with gastrointestinal disease. Gill et al (118) showed that 1.6% (11 of 690 cultures) of stool cultures were positive for DF-3. Ten of the 11 patients with DF-3-positive stool cultures in this study had underlying neoplastic disease: two each with common variable hypogammaglobulinemia, lymphoma, sarcoma, and breast cancer and single cases of angioblastic lymphadenopathy, metastatic colon cancer, and AIDS.…”

Section: Capnocytophaga Sppmentioning

confidence: 99%

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Recovery of uncommon bacteria from blood: association with neoplastic disease

Beebe

Koneman

1995

Clin Microbiol Rev

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Table 6 is a summary of the organisms discussed with a listing of the environmental source, the endogenous source, the predisposing factors including neoplasms, and the postulated mechanisms by which the organism can gain access to the circulation. The evidence considered indicates that the entrance of one of these microorganisms into the bloodstream of a human being depends on the presence of multiplicity of predisposing factors. In the majority of cases of bacteremia due to one of these unusual organisms, two or more predisposing factors are present. Certain predisposing factors, such as cancer chemotherapy or intravenous catheterization, often provide a barrier break, while others, such as liver disease, may render the host immune system less capable of clearing organisms from the circulation. For organisms such as Campy-lobacter, Listeria, and Salmonella spp., attributes that allow the invasion of a healthy host are present and seem to be enhanced by the simultaneous presence of a predisposing condition, such as liver disease, in the host. Although somewhat fragmentary, a number of individual case reports describe bacteremia due to one of these organisms occurring weeks to years after surgery and after other therapeutic measures had effected a supposed cure of a cancer. It may be speculated that cancer patients, even after a cure, are still susceptible to bloodstream invasion by one of the aforementioned organisms by virtue of the presence of one or more predisposing metabolic, physiologic, or immunologic factors, even though these factors may be cryptic. The predominance of hematologic malignancies among cases of bacteremia due to these unusual organisms is also apparent. Although, as pointed out by Keusch (169), the reduction in the performance of immune function in hematologic malignancies compared with solid tumors is likely to be responsible, other associations of certain organisms with specific neoplasms warrant further examination. The frequency of bloodstream infections of Salmonella typhimurium and Capno-cytophaga canimorsus in Hodgkin's disease patients seems likely due to a particular mechanism which infection by these species is favored. The specific nature of these mechanisms remains to be determined. The recovery of any unusual bacterium from blood should warrant a careful consideration of the possibility of underlying disease, especially cancer. Microbiologists should advise clinicians of the unusual nature of the identified organism and provide the counsel that certain neoplastic processes, often accompanied by neutropenia, render the human host susceptible to invasion by almost any bacterium. The recovery of such organisms as C. septicum or S. bovis should prompt the clinician to aggressively seek to identify an occult neoplasm if one has not yet been diagnosed.

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Pasteurella,Mannheimia,Actinobacillus,Eikenella,Kingella,Capnocytophaga, and Other Miscellaneous Gram-Negative Rods

Janda¹,

Mutters²

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Clinical and microbiological observations on CDC group DF-3, a gram-negative coccobacillus

Cited by 12 publications

References 4 publications

Clinical isolation of a DF-3 microorganism and review of the literature

Clinical isolation of a DF-3 microorganism and review of the literature

Recovery of uncommon bacteria from blood: association with neoplastic disease

Pasteurella,Mannheimia,Actinobacillus,Eikenella,Kingella,Capnocytophaga, and Other Miscellaneous Gram-Negative Rods

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