Clinical isolation of a DF-3 microorganism and review of the literature

Martínez-Sánchez, Lucía; Vasallo, Francisco J.; Garcı́a-Garrote, Fernando; Alcalá, Luís; Rodríguez‐Créixems, Marta; Bouza, Emilio

doi:10.1111/j.1469-0691.1998.tb00070.x

Cited by 10 publications

(3 citation statements)

References 9 publications

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“…Metabolic fatty acids produced by the blood isolate were propionic, lactic, and succinic acids, and the major cellular fatty acids were a-C 15:0 (26%), i-3-OH-C 16:0 (21%), i-C 14:0 (13%), 3-OH-C 16:0 (6%), C 16:0 (5%), i-C 15:0 (4%), C 15:0 (3%), C 16:17c (3%), and C 18:19c (3%). In line with previous results (1,2,4), the blood isolate was susceptible to amoxicillin-clavulanate, clindamycin, erythromycin, piperacillin-tazobactam, rifampin, tetracycline, and trimethoprim-sulfamethoxazole (Table 1). Pulsed-field gel electrophoresis did not reveal visible bands in any run.…”

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confidence: 91%

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Septicemia Caused by Dysgonic Fermenter 3 in a Severely Immunocompromised Patient and Isolation of the Same Microorganism from a Stool Specimen

Grob¹,

Zbinden²,

Ruef

et al. 1999

J Clin Microbiol

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confidence: 91%

“…The possible causative role of DF-3 in diarrhea was first noted 10 years ago in a patient with common variable hypogammaglobulinemia (8). Since then, 21 DF-3 stool isolates collected from immunosuppressed patients have been reported, but there was an association with diarrhea in only 50% of the cases (4).…”

mentioning

confidence: 99%

Septicemia Caused by Dysgonic Fermenter 3 in a Severely Immunocompromised Patient and Isolation of the Same Microorganism from a Stool Specimen

Grob¹,

Zbinden²,

Ruef

et al. 1999

J Clin Microbiol

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“…The even less common organism, Dysgonomonas spp. (formerly Centers for Disease Control and Prevention group DF-3) is said to be resistant to beta-lactams, macrolides, aminoglycosides, and quinolones (21). The testing conditions for Campylobacter spp.…”

Section: Fastidious Gram-negative Rodsmentioning

confidence: 99%

Need for Susceptibility Testing Guidelines for Fastidious or Less-Frequently Isolated Bacteria

Jorgensen

2004

J Clin Microbiol

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In the United States, clinical microbiology laboratories rely upon the National Committee for Clinical Laboratory Standards (NCCLS) for written standards that guide the important elements of antimicrobial susceptibility testing. Whether a laboratory performs a direct version of an NCCLS standard method (e.g., disk diffusion) or uses a commercial device that has been "cleared" by the Food and Drug Administration because it provides results that are essentially equivalent to the NCCLS reference dilution susceptibility method, the NCCLS standards provide important, up-to-date guidance on the most relevant drugs to report on specific organisms, quality control ranges to assure reproducible results, and "breakpoints" to interpret disk diffusion zones or MICs. Antimicrobial Disk Susceptibility Tests (26), and M7, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically (25), describe reference and standardized methods for antimicrobial susceptibility testing of common, rapidly growing aerobic bacteria, including staphylococci, enterococci, members of the Enterobacteriaceae, and Pseudomonas and Acinetobacter spp. (in addition to a few other non-glucose fermenters). During the past 15 years, the NCCLS Antimicrobial Susceptibility Testing (AST) subcommittee has expanded the list of standard susceptibility testing methods, quality control values, and interpretive breakpoints to include several fastidious bacterial species. Specialized media, modified incubation conditions, and specific breakpoints have been established for the testing of Haemophilus influenzae, Neisseria gonorrhoeae, and Streptococcus spp. (including Streptococcus pneumoniae). In addition, there is a limited amount of information on the testing of Helicobacter pylori, Listeria spp., N. meningitidis, Vibrio cholerae, and Bacillus anthracis (25,26). DEVELOPMENT OF NCCLS TESTING CRITERIA NCCLS documents M2, Performance Standards forIn order to establish MIC interpretive breakpoints for new antimicrobial agents, to modify existing breakpoints, or to establish breakpoints for organisms for which breakpoints have not previously existed, the AST subcommittee has used a detailed analysis of four different types of data (24). This begins with an analysis of MIC ranges of a particular drug with isolates that lack known resistance mechanisms to determine the intrinsic degree of susceptibility of a species. Next, the susceptibility to the drug is determined with strains that contain known resistance mechanisms that affect the activity of the particular drug class in order to assess the impact of that resistance mechanism.In recent years the AST subcommittee has found pharmacokinetic and pharmacodynamic determinations to be a very valuable third aspect of establishing breakpoints. The recognition of the importance of the time the drug levels in blood are maintained above the drug's proposed MIC breakpoint (T Ͼ MIC; with beta-lactams, glycopeptides, macrolides) or the area under the drug concentration curve in blood divided by the prop...

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Dysgonomonas

Olsen¹

2015

Bergey's Manual of Systematics of Archaea and Bacteria

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Dys.go.no.mo'nas. Gr. pref. dys ‐ with notion of hard, bad, unlucky; Gr. n. gonos that which is begotten, reproduction; Gr. fem. n. monas a monad, unit; N.L. fem. n. Dysgonomonas intended to mean a weakly growing monad. Bacteroidetes / Bacteroidia / Bacteroidales / Porphyromonadaceae / Dysgonomonas Coccobacilli to short rods. Nonmotile. Gram‐negative. Facultatively anaerobic. Colonies are 1–2 mm in diameter, nonadherent, entire, gray–white, smooth, and nonhemolytic and have a slight aromatic odor. Growth is not observed on MacConkey agar. Requires X factor for growth. May be catalase‐positive or ‐negative. Oxidase‐negative. Glucose is fermented, producing acid but no gas. Alkaline phosphatase is generated but not arginine dihydrolase. Nitrate is not reduced. H 2 S and acetoin are not produced. Esculin may not be hydrolyzed; gelatin and urea are not hydrolyzed. Indole may be produced. Long‐chain cellular fatty acids include straight‐chain saturated, anteiso‐ and iso‐methyl branched and 3‐hydroxy types. Isolated from human clinical specimens and stools. DNA G + C content ( mol %): 38 ( T m ). Type species : Dysgonomonas gadei Hofstad, Olsen, Eribe, Falsen and Lawson 2000, 2194 VP .

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Clinical isolation of a DF-3 microorganism and review of the literature

Cited by 10 publications

References 9 publications

Septicemia Caused by Dysgonic Fermenter 3 in a Severely Immunocompromised Patient and Isolation of the Same Microorganism from a Stool Specimen

Septicemia Caused by Dysgonic Fermenter 3 in a Severely Immunocompromised Patient and Isolation of the Same Microorganism from a Stool Specimen

Need for Susceptibility Testing Guidelines for Fastidious or Less-Frequently Isolated Bacteria

Dysgonomonas

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