Clinical and microbiological field studies in the Netherlands of diarrhoea in pigs at weaning

Nabuurs, M.J.A.; Zijderveld, F.G. van; Leeuw, Peter W. de

doi:10.1016/0034-5288(93)90037-g

Cited by 37 publications

(29 citation statements)

References 22 publications

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“…There was a rapid initial increase in ETEC shedding in the faeces of challenged pigs immediately post infection followed by a gradual decrease. Others have reported the same pattern over a similar time period (Nabuurs et al, 1993;Kiers et al, 2003).…”

Section: Discussionsupporting

confidence: 58%

“…This was observed here with pigs weaned at 4 weeks of age demonstrating a much larger decrease in villous height and V : C ratio from days 0 to 6 than pigs weaned at 6 weeks of age. The fact that infection had little impact on villi atrophy, a common feature associated with clinical PWC (Kenworthy, 1976;Nabuurs et al, 1993;McDonald et al, 2001), supports the view that sub-clinical rather than clinical PWC was induced. Infection had a greater detrimental effect on the enteric health, as indicated by a higher pH, lower L : C ratio of the PC contents and lower villous heights at all three sites of the small intestine, of pigs weaned at 4 weeks than those weaned at 6 weeks of age.…”

Section: Discussionmentioning

confidence: 89%

“…After weaning, villous height is generally reduced and crypt depth increased (Miller et al, 1984;Pluske et al, 1996;Vente-Spreeuwenberg et al, 2003), which may be associated with increased occurrence of diarrhoea (Nabuurs et al, 1993). These changes in gut morphology are primarily related to the low feed intake post-weaning (Kelly et al, 1991;Pluske et al, 1996), being lowest around day 4 before recovering to pre-weaning values between days 11 and 14 (Nabuurs et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…These changes in gut morphology are primarily related to the low feed intake post-weaning (Kelly et al, 1991;Pluske et al, 1996), being lowest around day 4 before recovering to pre-weaning values between days 11 and 14 (Nabuurs et al, 1993). Older pigs therefore may be expected to show less of a decrease in villous height due to a greater feed intake.…”

Section: Discussionmentioning

confidence: 99%

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Effects of dietary protein supply, weaning age and experimental enterotoxigenic Escherichia coli infection on newly weaned pigs: health

Wellock

Fortomaris

Houdijk

et al. 2008

Animal

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Weaning is often associated with post-weaning colibacillosis (PWC), caused by enterotoxigenic Escherichia coli (ETEC). The objective was to investigate the effects of manipulating dietary protein supply and increasing weaning age on enteric health and ETEC shedding of newly weaned pigs exposed to an experimental ETEC challenge. The experiment consisted of a complete 2 3 2 3 2 factorial combination of weaning age (4 v. 6 weeks), dietary protein content (H, 230 g crude protein (CP)/kg v. L, 130 g CP/kg) and experimental ETEC challenge (1 v. 2); all foods were free from in-feed antimicrobial growth promoters (AGP). An additional four treatments were added to allow the effect of protein source (DSMP, dried skimmed milk powder v. SOYA, soybean meal) and AGP inclusion (yes v. no) to be investigated in challenged pigs of both weaning ages. On day 3 post-weaning challenged pigs were administered per os with 10 9 cfu ETEC O149. A subset of pigs was euthanased on days 0 and 6 post weaning to assess enteric health and small intestine morphology. Both weaning age and dietary protein content affected the consequences of ETEC challenge. ETEC excretion persisted longer in the 4-week-weaned pigs than those weaned at 6 weeks. Although not significant, the numbers of ETEC shed in the faeces post infection (days 4 to 14) were higher on the H than L diet, especially in the 4-week-weaned pigs (P 5 0.093). Lowering CP level led to significantly firmer faeces post challenge (days 3 to 6) and decreased colonic digesta pH. Protein level had no effect on small intestine villous heights or crypt depths. There was no significant effect of protein source on ETEC excretion or enteric health. Results suggest that increasing weaning age and decreasing the level of dietary protein, especially in earlier weaned pigs, may help to maintain enteric health and minimise the effects of PWC.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of dietary protein supply, weaning age and experimental enterotoxigenic Escherichia coli infection on newly weaned pigs: health

Wellock

Fortomaris

Houdijk

et al. 2008

Animal

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“…The stress caused by the environmental, social and dietary changes is thought to predispose to post-weaning diarrhoea (Nabuurs et al, 1993;Melin et al, 2003). However, weaning is not considered to predispose to dysentery, and repeated injections of the stress hormone dexamethasone in growers did not provoke clinical disease.…”

Section: Discussionmentioning

confidence: 99%

Experimental swine dysentery: comparison between infection models

Jacobson

Fellström

Lindberg

et al. 2004

Journal of Medical Microbiology

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The aim of the present study was to develop a reproducible porcine infection model with Brachyspira hyodysenteriae. The influence of different factors was evaluated, namely, age, a diet containing large quantities of soybean meal, housing and administration of cortisol or antacids. Furthermore, the synergistic effect of additional bacteria (Escherichia coli O141, Bacteroides vulgatus or a mixture of Bacteroides fragilis, a field isolate of Bacteroides and Fusobacterium necrophorum) was studied. Experimental infection resulted in an increase in the serum concentrations of the acute-phase proteins serum amyloid A and haptoglobin and the percentages of neutrophils and monocytes. These alterations were specifically related to haemorrhagic diarrhoea. Inoculation combined with feeding of large quantities of soybean meal and group-housing induced swine dysentery in all experimental animals. If the pigs were fed soybean meal, kept in single pens and circulated between the pens, five out of nine developed disease.

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Villus height and crypt depth in weaned and unweaned pigs, reared under various circumstances in the Netherlands

Nabuurs

Hoogendoorn²,

Molen³

et al. 1993

Research in Veterinary Science

157

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Clinical and microbiological field studies in the Netherlands of diarrhoea in pigs at weaning

Cited by 37 publications

References 22 publications

Effects of dietary protein supply, weaning age and experimental enterotoxigenic Escherichia coli infection on newly weaned pigs: health

Effects of dietary protein supply, weaning age and experimental enterotoxigenic Escherichia coli infection on newly weaned pigs: health

Experimental swine dysentery: comparison between infection models

Villus height and crypt depth in weaned and unweaned pigs, reared under various circumstances in the Netherlands

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