Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo‐controlled clinical trial

Pradeep, A.R.; Singh, Sonender Pal; Martande, Santosh S.; Naik, Savitha B.; Priyanka, N; Kalra, Nitish; Suke, Deepak Kumar

doi:10.1111/jicd.12091

Cited by 17 publications

(24 citation statements)

References 44 publications

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“…Systemic levofloxacin and moxifloxacin improve the clinical outcomes of periodontitis and suppress A actinomycetemcomitans below detectable levels. 14 , 15 In our case, the antibiotic resistance to levofloxacin before the corneal transplantation, however, was contrary to these reports, but was consistent with histopathologic results; this revealed that the infection focus was located in the deep corneal stroma, leading to poor corneal drug penetration and a low antibiotics concentration. Similarly to an Actinomyces-induced keratitis case after keratoplasty, 6 A actinomycetemcomitans was difficult to eradicate medically in our case, and required surgical intervention.…”

Section: Discussionsupporting

confidence: 75%

Actinobacillus actinomycetemcomitans Keratitis After Glaucoma Infiltration Surgery

Hong

Cao

et al. 2016

Medicine

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Actinobacillus actinomycetemcomitans infection is a rare and easily misdiagnosed ocular disease. In this article, the authors report a chronic, purulent, and difficult-to-treat case of A actinomycetemcomitans keratitis following a glaucoma infiltration surgery.A 56-year-old man with a long-standing history of open-angle glaucoma in both eyes presented with a 12-week history of ocular pain, redness, and blurred vision in his right eye. He underwent a glaucoma infiltration surgery in his right eye 6 months ago. Three months postoperatively, he developed peripheral corneal stromal opacities associated with a white, thin, cystic bleb, and conjunctival injection. These opacities grew despite topical treatment with topical tobramycin, levofloxacin, natamycin, amikacin, and metronidazole eye drops.Multiple corneal scrapings revealed no organisms, and no organisms grew on aerobic, anaerobic, fungal, or mycobacterial cultures. The patient's right eye developed a severe purulent corneal ulcer with a dense hypopyon and required a corneal transplantation. Histopathologic analysis and 16S ribosomalribonucleic acid polymerase chain reaction sequencing revealed A actinomycetemcomitans as the causative organism. Postoperatively, treatment was initiated with topical levofloxacin and cyclosporine, as well as oral levofloxacin and cyclosporine. Graft and host corneal transparency were maintained at the checkup 1 month after surgery.Although it is a rare cause of corneal disease, A actinomycetemcomitans should be suspected in patients with keratitis refractory to topical antibiotic therapy. Delay in diagnosis and appropriate treatment can result in vision loss.

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Section: Discussionsupporting

confidence: 75%

Actinobacillus actinomycetemcomitans Keratitis After Glaucoma Infiltration Surgery

Hong

Cao

et al. 2016

Medicine

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“…A total of 18 756 citations were found during the electronic and manual search; after reviewing title and abstract, 451 studies were considered as relevant and were further screened ( κ = 0.84). Of these, 106 papers were evaluated for the full‐text examination ( κ = 0.91): Finally, 85 studies were excluded ( κ = 0.98), since they did not satisfy the eligibility criteria (Table ), and the remaining 21 28‐48 studies were included in the systematic review.…”

Section: Resultsmentioning

confidence: 99%

Adjunctive systemic antimicrobials in the treatment of chronic periodontitis: A systematic review and network meta‐analysis

Sgolastra¹,

Petrucci²,

Ciarrocchi

et al. 2020

J of Periodontal Research

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The aim of this systematic review and network meta‐analysis was to assess the efficacy of antimicrobials adjunctive to scaling and root planing (SRP) in the treatment of chronic periodontitis. The study was conducted according to the PRISMA statement. The protocol (CRD42020178621) was registered on the International Prospective Register of Systematic Reviews (PROSPERO). The MEDLINE, EMBASE, and CENTRAL databases were searched up to March 2020; furthermore, a manual search of relevant periodontal journals was conducted. Mean differences (MD) and standard deviations were calculated for clinical attachment level (CAL) gain and probing depth (PD) reduction at 6 and 12 months. A network meta‐analysis was performed to assess direct and indirect comparisons and to establish a ranking of treatments. A total of 21 randomized clinical trials (RCTs) were included in the systematic review. Network meta‐analysis showed that SRP + amoxicillin (AMX) + metronidazole (MTZ), as compared to SRP, reached the highest PD reduction at 6 [MD = 0.47; 95% CI (0.3; 0.64)] and 12 months [MD = 0.51; 95% CI (0.25; 0.78)], and CAL gain at 6 [MD = 0.54; 95% CI (0.27; 0.8)] and 12 months [MD = 0.37; 95% CI (0.05; 0.69)]. Network meta‐analysis indicated that AMX + MTZ adjunctive to SRP provided the best improvement in clinical parameters, followed by SRP + MTZ.

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“…Though not proven to be a truly causative species, the presence of Aa heralds active disease while difficulty in isolation from periodontal pockets signifies remission including chronic and aggressive periodontitis . Many studies adopted Aa as a reliable marker for predicting treatment outcomes in addition to clinical parameters . PDT is regarded as a broad anti‐bacterial therapy and has shown efficacy against Aa when studied in vitro …”

Section: Discussionmentioning

confidence: 99%

Effect of photodynamic therapy adjunct to scaling and root planing in periodontitis patients: A randomized clinical trial

Pulikkotil

Toh

Mohandas

et al. 2016

Australian Dental Journal

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Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo‐controlled clinical trial

Abstract: Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals.

Cited by 17 publications

References 44 publications

Actinobacillus actinomycetemcomitans Keratitis After Glaucoma Infiltration Surgery

Actinobacillus actinomycetemcomitans Keratitis After Glaucoma Infiltration Surgery

Adjunctive systemic antimicrobials in the treatment of chronic periodontitis: A systematic review and network meta‐analysis

Effect of photodynamic therapy adjunct to scaling and root planing in periodontitis patients: A randomized clinical trial

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