Clinical and microbiological characterization of localized aggressive periodontitis: a cohort study

Abstract

Background: Localized aggressive periodontitis (LAgP) is an infectious periodontal disease which generally affects young people. Recent data suggest the involvement of different bacterial species in different populations. The causative bacterial species in Israel has never been identified despite a high prevalence of LAgP in this population. The objectives of this study were to characterize the bacterial microbiota of periodontal pockets within an Israeli LAgP population who were also clinically assessed. Methods: Twenty-one LAgP patients (test) and 12 chronic periodontitis patients (control) were examined. Bacterial samples were collected from periodontal pockets and analysed by both culture and polymerase chain reaction techniques. Mann-Whitney U test and chi-square test were used to compare results between the groups. Results: Higher levels of Parvimonas micra (>10

Microbiological analysis and the outcomes of periodontal treatment with or without adjunctive systemic antibiotics—a retrospective study

“…Comparing AP and CP, more positive results of A. actinomycetemcomitans and E. nodatum were found in AP patients. Regarding A. actinomycetemcomitans, this finding confirms those of a recent study where about 70% of positive samples were detected in patients diagnosed with localized AP [30]. In our study, half of the AP patients have been tested positively for A. actinomycetemcomitans.…”

Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes

“…Additionally, F. nucleatum recently has been implicated as a potential target pathogen (26). F. nucleatum also is prevalent within deep periodontal pockets of LAP patients (27), and its abundance in the biofilm is associated with the severity of periodontal inflammation in adolescents (28). In addition, F. nucleatum is essential for the growth of P. gingivalis and A. actinomycetemcomitans (29), and it can synergistically create a stronger inflammatory response with more tissue destruction in coinfections with P. gingivalis in a mouse periodontitis model (30).…”

Classification and diagnosis of aggressive periodontitis

“…Studies from 1998 forward examined a broad spectrum of bacteria using DNA technologies (Table ) . In one‐half the studies Aggregatibacter actinomycetemcomitans was implicated as a risk marker, and in another half Porphyromonas gingivalis , Tannerella forsythia , and Selenomonads emerged as markers of risk (Table ).…”

“…Studies from 1998 forward examined a broad spectrum of bacteria using DNA technologies ( Table 2). [23][24][25][26][27][28][29][30][31][32][33][34][35][36] In one-half the studies Aggregatibacter actinomycetemcomitans was implicated as a risk marker, and in another half Porphyromonas gingivalis, 23,25,27,[32][33][34][35] Tannerella forsythia, 27,29,32,34,35 and Selenomonads emerged as markers of risk (Table 2). A recent study 37 showed that in younger individuals A. actinomycetemcomitans was associated with disease whereas this was not the case in older subjects.…”