Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo‐controlled study

Matarazzo, Flávia; Figueiredo, Luciene Cristina; Cruz, Sergio Eduardo Braga; Faveri, Marcelo; Feres, Magda

doi:10.1111/j.1600-051x.2008.01304.x

Cited by 136 publications

(277 citation statements)

References 72 publications

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“…Some authors justify this use by claiming difficulties in eliminating subgingival pathogens in smokers with SRP. 32,33,34 Although there is substantial evidence for the benefits of systemic antibiotic therapy in the treatment of periodontitis in general, 35,36,37 few controlled studies have evaluated the effectiveness of periodontal treatment with adjunctive systemic antibiotics in smokers, 38,39,40,41,42,43,44,45 and the differential benefit of specific forms of periodontal therapy in smokers remains unclear. Given these facts, there is currently no consensus on the use of systemic antibiotics for the periodontal treatment of smokers.…”

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confidence: 99%

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

et al. 2017

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The aim of this study was to perform a systematic review and meta-analysis to examine the effect of systemic antibiotics in the periodontal treatment of smokers. The selection criteria were as follows: controlled randomized clinical trials; studies published in English; studies with smoker patients diagnosed with chronic periodontitis; patients without systemic diseases; studies that used systemic antibiotic therapy associated with periodontal treatment; studies that presented results for the test and control groups and assessments of clinical periodontal parameters, such as probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). The differences in average weights were calculated with a confidence interval (CI) of 95% for PD reduction, CAL gain and BOP. The means of the periodontal clinical parameters were compared between the baseline and post-treatment periods between the test groups and the control groups. The heterogeneity was assessed using the Cochran Q test (Q (df = 3), α = 5%). A total of 67 articles were found, and after the selection process, three randomized controlled trials were included in the meta-analysis. The results indicate that SRP associated with systemic antibiotics promoted additional benefits when compared to SRP alone, with a greater reduction of PD (p = 0.0359, CI = -0.42, -0.01) and a gain of CAL (p = 0.0161, CI = -0.39, -0.04). There was a modest PD reduction (PD, DM -0.21) and a modest CAL gain (CAL, DM -0.22). The results of our meta-analysis reveal the clinical benefits of systemic antibiotics as an adjunct to the non-surgical periodontal treatment of smokers. These clinical improvements, although statistically significant, appeared to be of little clinical relevance.

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Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

et al. 2017

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“…The exclusion criteria were: smokers (≥10 cigarettes/day for ≥5 years) 16 , ex-smokers (≥5 years) 17 , pregnant women or nursing mothers, history of periodontal treatment in the last six months, continuous use of oral antiseptics, use of systemic antibiotics, corticosteroids, non steroid anti-inflammatory agents, immunosuppressive agents, estrogen and estrogen receptor modulators and any medications that may influence bone metabolism (alendronate, calcitonin and others) in the last six months, systemic disease that may change the host response (e.g.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Evaluation of Enterococcus faecalis, Staphylococcus warneri and Staphylococcus aureus species in adults with generalized chronic periodontitis

Fritoli

Lobão

Soares

et al. 2017

RGO, Rev. Gaúch. Odontol.

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Objective To identify and quantify the levels of three bacterial species that have recently been identified as potential "new" periodontal pathogens (Enterococcus faecalis, Staphylococcus aureus and Staphylococcus warneri) in subjects with periodontal health and generalized chronic periodontitis. Methods RESUMOObjetivo Identificar e quantificar os níveis de três espécies bacterianas que foram recentemente apontadas como possíveis "novos" patógenos periodontais (Enterococcus faecalis, Staphylococcus warneri e Staphylococcus aureus), em indivíduos periodontalmente saudáveis e com periodontite crônica generalizada. MétodosA amostra foi composta por 30 indivíduos adultos com periodontite crônica generalizada e 10 periodontalmente saudáveis. Nove amostras de biofilme subgengival foram coletadas por indivíduo e analisadas individualmente pela técnica de checkerboard DNA-DNA hybridization. ResultadosOs níveis médios de E. faecalis e S. warneri foram maiores no grupo com periodontite crônica do que no de saúde periodontal (p<0,05). Além disso, um maior percentual de indivíduos com periodontite estavam colonizados pelas três espécies avaliadas em comparação com os indivíduos saudáveis (p<0,05). Essa diferença entre os dois grupos foi de 40 pontos percentuais para E. faecalis (presente em 90% dos indivíduos com periodontite e 50% dos saudáveis) e S. warneri (100% e 60%, respectivamente), e de 26 pontos percentuais para S. aureus (86% e 60%, respectivamente). Conclusão E. faecalis e S. warneri tem potencial para serem patógenos periodontais. O papel do S. aureus foi menos evidente, uma vez que esta espécie estava mais prevalente e em níveis relativamente mais altos do que as outras duas espécies em saúde. Estes dados podem guiar futuros estudos sobre o papel dessas espécies na etiologia das periodontites e ajudar a estabelecer tratamentos mais eficazes para essas infecções.Termos de indexação: Periodontite crônica. Microbiota. Noxas. Doenças periodontais.

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“…Checkerboard DNA-DNA hybridization Counts of three bacterial species were determined in each sample, using the Checkerboard DNA-DNA hybridization technique 6 as previously described by Matarazzo et al (2008). 8 The assay adjusted the sensitivity of the assay to permit detection of 10 4 cells of a given species by adjusting the concentration of each DNA probe.…”

Section: Banamentioning

confidence: 99%

“…8 The assay adjusted the sensitivity of the assay to permit detection of 10 4 cells of a given species by adjusting the concentration of each DNA probe. Signals were converted to absolute counts by comparison with the standard lanes on the membrane.…”

Section: Banamentioning

confidence: 99%

“…This technique has showed better results in comparison with other microbiological tests. [7][8][9][10][11] Socransky et al 3 (1998) described the presence of five, and subsequently six microbial groups 12 within subgingival biofilm. A group of species denominated the red complex consisted of three species: P. gingivalis, T. forsythia and T. denticola.…”

Section: Introductionmentioning

confidence: 99%

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The ability of the BANA test to detect different levels of P. gingivalis, T. denticola and T. forsythia

et al. 2010

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The aim of this study was to evaluate the ability of the BANA Test to detect different levels of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia or their combinations in subgingival samples at the initial diagnosis and after periodontal therapy. Periodontal sites with probing depths between 5-7 mm and clinical attachment level between 5-10 mm, from 53 subjects with chronic periodontitis, were sampled in four periods: initial diagnosis (T0), immediately (T1), 45 (T2) and 60 days (T3) after scaling and root planing. BANA Test and Checkerboard DNA-DNA hybridization identified red complex species in the subgingival biofilm. In all experimental periods, the highest frequencies of score 2 (Checkerboard DNA-DNA hybridization) for P. gingivalis, T. denticola and T. forsythia were observed when strong enzymatic activity (BANA) was present (p < 0.01). The best agreement was observed at initial diagnosis. The BANA Test sensitivity was 95.54% (T0), 65.18% (T1), 65.22% (T2) and 50.26% (T3). The specificity values were 12.24% (T0), 57.38% (T1), 46.27% (T2) and 53.48% (T3). The BANA Test is more effective for the detection of red complex pathogens when the bacterial levels are high, i.e. in the initial diagnosis of chronic periodontitis.

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Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: a randomized placebo‐controlled study

Abstract: Significant advantages are observed when systemic antibiotics are combined with SRP in the treatment of smokers with chronic periodontitis. The greatest benefits in clinical and microbiological parameters are achieved with the use of SRP+MTZ+AMX.

Cited by 136 publications

References 72 publications

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

Evaluation of Enterococcus faecalis, Staphylococcus warneri and Staphylococcus aureus species in adults with generalized chronic periodontitis

The ability of the BANA test to detect different levels of P. gingivalis, T. denticola and T. forsythia

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