Clinical and Microbiologic Consequences of Amikacin Use During a 42-Month Period

Departmental consumption of antibiotic drugs and subsequent resistance: a quantitative link

“…For example, some studies showed a lesser impact of amikacin consumption than of gentamicin consumption on resistance. 16,17 The opposite was shown in our data. A similar analysis applied at other hospitals should show how robust our results are.…”

Ciprofloxacin or Imipenem Use Correlates with Resistance in Pseudomonas aeruginosa

“…Some reports have demonstrated a relationship between antimicrobial use and bacterial resistance (12,13), while others have not confirmed this correlation (5). Studies performed with aminoglycosides have either been prospective studies in which a baseline period was followed by an extensive usage period of one aminoglycoside (7,(14)(15)(16), usually amikacin, or retrospective studies reporting the frequency of aminoglycoside resistance among clinical isolates over several years (17,18). The majority of these studies have demonstrated a clear relationship between the use of gentamicin, tobramycin and kanamycin, and bacterial resistance (7,(14)(15)(16).…”

“…Studies performed with aminoglycosides have either been prospective studies in which a baseline period was followed by an extensive usage period of one aminoglycoside (7,(14)(15)(16), usually amikacin, or retrospective studies reporting the frequency of aminoglycoside resistance among clinical isolates over several years (17,18). The majority of these studies have demonstrated a clear relationship between the use of gentamicin, tobramycin and kanamycin, and bacterial resistance (7,(14)(15)(16). However, with amikacin, several studies have not shown a relationship between amikacin use and amikacin resistance (7,(14)(15)(16), while other studies have reported increased amikacin resistance with increased amikacin use (17,18).…”

“…The majority of these studies have demonstrated a clear relationship between the use of gentamicin, tobramycin and kanamycin, and bacterial resistance (7,(14)(15)(16). However, with amikacin, several studies have not shown a relationship between amikacin use and amikacin resistance (7,(14)(15)(16), while other studies have reported increased amikacin resistance with increased amikacin use (17,18).…”

Minimizing Antimicrobial Resistance in Hospital Bacteria: Can Switching or Cycling Drugs Help?

“…Berk 5 Yurasek 6 Moody 7 Wielunsky 8 Cross 9 Betts 10 Saravolatz 11 Period 1 Period 2 Shulman 12 Levine 13 Gerding 14 UVAHosps changes in the procedures and techniques performed (again, changing widely in response to the new economic forces), increased influence of organisms causing community-acquired infection (arising in part from today's rush to move the patient out of the hospital), and differences in prevalence of organisms from hospital to hospital. Such non-antibiotic factors may explain in part why increases in prevalence of resistant organisms are so strikingly location-specific.…”