Ciprofloxacin or Imipenem Use Correlates with Resistance in <i>Pseudomonas aeruginosa</i>

Zhanel, George G.; Nicolle, Lindsay E.; Gin, Alfred S.; Karlowsky, James A.; Kabani, Amin; Hoban, Daryl J.

doi:10.1155/1998/210742

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…7-10 Ciprofloxacin use was shown to be directly associated with higher ciprofloxacin resistance in P. aeruginosa and Enterobacteriaceae, and a significant reduction in ciprofloxacin use was associated with small but significant improvements in ciprofloxacin susceptibility among P. aeruginosa nosocomial isolates. 4,[11][12][13] In one study a mathematical model predicts that changes in the prevalence of resistance after a successful intervention will occur on a time-scale of weeks to months in a hospital setting, considerably faster than in community-acquired infections. 14 In this study, we have demonstrated a significant decrease in ciprofloxacin resistance in ESBL-producing urinary isolates of E. coli both in hospital and community within four months as fluoroquinolone hospital usage fell to ≤2/DDD/100 OBD.…”

Section: Discussionmentioning

confidence: 99%

Effects of fluoroquinolone restriction (from 2007 to 2012) on resistance in Enterobacteriaceae: interrupted time-series analysis

Sarma

Marshall

Cleeve

et al. 2015

Journal of Hospital Infection

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Section: Discussionmentioning

confidence: 99%

Effects of fluoroquinolone restriction (from 2007 to 2012) on resistance in Enterobacteriaceae: interrupted time-series analysis

Sarma

Marshall

Cleeve

et al. 2015

Journal of Hospital Infection

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Antibacterial Use in Community Practice

Carrie

Zhanel

1999

Drugs

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Most use of antibacterials occurs in community practice; however, despite the widespread belief of inappropriate use and the resultant increase in antibacterial resistance, little data exist describing antibacterial use in this setting. A MEDLINE search of English-language articles was conducted for epidemiological studies assessing quantity, indication and appropriateness of antibacterial use in community practice. A 1983 study of international antibacterial use described considerable disparities in quantity of use between countries. Subsequent longitudinal studies from the US, Canada, Australia and the UK described changing patterns of antibacterial use. No increase in the total rate of antibacterial use was reported by any of the 4 countries; however, all countries reported increased use of newer and/or broad-spectrum agents (e.g. fluoroquinolones, amoxicillin-clavulanic acid, cephalosporins and new macrolides] coupled with decreased use of older and/or narrow-spectrum agents [e.g. phenoxymethylpenicillin (penicillin V), erythromycin, ampicillin and tetracycline). Most (approximately three-quarters) use of antibacterials was in the treatment of respiratory tract infections. Prescribing rates for respiratory tract infections of presumed viral aetiology (e.g. the common cold) ranged from 17 to 60% in the UK and US, respectively. Among indications for which antibacterials were indicated, the appropriateness of antibacterial use received little study. Correspondingly, the rates of antibacterial resistance among common respiratory pathogens (Streptococcus pneumoniae and Haemophilus influenzae) have increased significantly in the past decade, although disparities exist between countries. Antibacterial use is considered a major factor in the development of antibacterial resistance, although the relationship between community antibacterial use and resistance has been poorly described. Further study of antibacterial usage patterns and associated resistance patterns is fundamental to the development of methods to reduce unnecessary and inappropriate use, thereby slowing the development of antibacterial resistance in the community.

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Antibacterial Drivers of Resistance

Zhanel

2005

Treatments in Respiratory Medicine

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Ciprofloxacin or Imipenem Use Correlates with Resistance in Pseudomonas aeruginosa

Abstract: Ciprofloxacin use was directly associated with ciprofloxacin resistance, and imipenem use was directly associated with imipenem resistance in P aeruginosa.

Cited by 3 publications

References 21 publications

Effects of fluoroquinolone restriction (from 2007 to 2012) on resistance in Enterobacteriaceae: interrupted time-series analysis

Effects of fluoroquinolone restriction (from 2007 to 2012) on resistance in Enterobacteriaceae: interrupted time-series analysis

Antibacterial Use in Community Practice

Antibacterial Drivers of Resistance

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