Clinical and Metabolic Effects of Phenethylbiguanide

Bergen, Stanley S.; Norton, William S.

doi:10.2337/diab.9.3.183

Cited by 9 publications

(1 citation statement)

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“…It is possible that rapid i. v. tests do not measure glucose utilization to the same extent as tests in wbich glucose is maintained at a high level for a longer period of time. The fall in the fasting values of FF A appears to be a direct effect of the biguanide and corroborates the results of Bergen and Norton (1960), and of Arky and Abramson (1968), with phenformin. In contrast, Kattermann, Appels, Hubrich, Proschek, Söling and Creutzfeldt (1968) observe an increase of FF A levels after eight weeks of treatment with butylbiguanide.…”

Section: Discussionsupporting

confidence: 88%

Metabolic Effects of Butylbiguanide During Long Lasting Intravenous Glucose Infusion in Normal Human Subjects

Gómez¹,

Jp²

1970

Horm Metab Res

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In a previous report, butylbiguanide was found to increase the oral glucose tolerance in normal human subjects, but left the K-value unchanged during rapid intravenous tolerance tests. The present report shows, that butylbiguanide increases the glucose tolerance of normal human subjects even when glucose is given intravenously over a long period of time (6-hour infusion). The radioimmunological serum insulin (lRI) was not significantly changed. The free fatty acids (FF A), however, were significantly lowered. This appeared to be a direct effect of the drug which could account for its blood glucose lowering action.

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Section: Discussionsupporting

confidence: 88%