Metabolic Effects of Butylbiguanide During Long Lasting Intravenous Glucose Infusion in Normal Human Subjects

Gómez, Fulgencio; Jp, Felber

doi:10.1055/s-0028-1095111

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Another often stated assumption is that biguanides stimulate peripheral glucose utilization [7,8,19,21,22]. The mechanisms which might be involved are not clear.…”

Section: Discussionmentioning

confidence: 99%

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The effect of phenformin-HCl on patients with diabetes mellitus, studied under strict balance conditions

1975

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Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by positive nitrogen, phosphorus and calcium balances. The weight gain can be explained by the positive caloric balance, mainly caused by the diminished glycosuria. No change in B.M.R. or R.Q. was seen. During phenformin treatment there was a drop in cholesterol and total lipid levels in 4 patients. No conclusions could be drawn about the effect of phenformin on triglycerides, phospholipids and lipoprotein spectra. Phenformin treatment did not affect the disappearance of glucose, nor the insulin levels after intravenous glucose loading. During oral glucose loading phenformin caused a significant fall in blood glucose levels, accompanied by an increased insulin response in one patient. In the other 4 patients phenformin had no effect on either parameter.

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“…Another often stated assumption is that biguanides stimulate peripheral glucose utilization [7,8,19,21,22]. The mechanisms which might be involved are not clear.…”

Section: Discussionmentioning

confidence: 99%

“…Biguanides are used mainly to treat the elderly obese diabetic. According to many investigators biguanides reduce the elevated blood glucose level [7,8,11,13,17,21,37], body weight [1,4,11,17,18,34,37,42] and glucose excretion in urine [11]. A concomitant reduction of elevated cholesterol [1], triglyceride and insulin levels [24,28,34] has been reported.…”

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confidence: 99%

The effect of phenformin-HCl on patients with diabetes mellitus, studied under strict balance conditions

1975

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Die Wirkung oral verabreichten Butyl-Biguanids auf die orale Glucosetoleranz und renale Glucoseresorption (TmG) beim gesunden Menschen in vivo

et al. 1975

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1. Oral glucose tolerance in 11 normal subjects was significantly improved after peroraI administration of 150 mg of butyl-biguanide.2. On the other hand maximum capacity of renal glucose reabsorption (Tm~) and lowest glomerular glucose filtration rate at which glucosuria was recorded (Fmln) remained uninfluenced after 150 mg of butyl-biguanide in 7 normal subjects.3. These results are compatible with the hypothesis that the oral administration of therapeutic doses of biguanides yields concentrations at the luminal face of the intestine which inhibit glucose resorption. Plasma concentrations following oral intake of the same dose of biguanide are too low to exert any inhibiting action on renal glucose reabsorption as demonstrated by the present in vivo studies.4. Urinary flow rate and inulin clearance remained unaltered after butyl-biguanide in these normal subjects.

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Metabolic Effects of Butylbiguanide During Long Lasting Intravenous Glucose Infusion in Normal Human Subjects

Cited by 2 publications

References 6 publications

The effect of phenformin-HCl on patients with diabetes mellitus, studied under strict balance conditions

The effect of phenformin-HCl on patients with diabetes mellitus, studied under strict balance conditions

Die Wirkung oral verabreichten Butyl-Biguanids auf die orale Glucosetoleranz und renale Glucoseresorption (TmG) beim gesunden Menschen in vivo

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