Clinical and laboratory studies into the pathogenesis of malacoplakia.

Lewin, Klaus J.; Wr, Fair; Steigbigel, Roy T.; Winberg, Carl D.; Droller, Michael J.

doi:10.1136/jcp.29.4.354

“…Malakoplakia is usually associated with chronic urinary tract infections, although numerous cases have been reported from a variety of other sites [1][2][3][4][5]. Many patients with malakoplakia have an underlying de bilitating disease [2, 3, 5| and malakoplakia has been reported in patients with organ transplants [6|.…”

mentioning

confidence: 99%

“…As a result of impaired intracellular killing, the infection becomes chronic. Histological ly there is a proliferation of histiocytes with abundant pink cytoplasm containing partial ly digested bacterial breakdown products within lysosomes [2,3]. Some of the lyso somes become calcified and have a charac- teristic histologic appearance; they are termed Michaelis-Gutmann bodies, and arc considered pathognomonic of malakoplakia.…”

mentioning

confidence: 99%

Malakoplakia of the Lung

Colby

¹

,

Hunt

²

,

Pelzmann

³

et al. 1980

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We have presented the clinical, radiologic and pathologic features of 2 patients with pulmonary malakoplakia. The histologic features, including diagnostic Michaelis-Gutmann bodies, were identical to those in the urinary tract where malakoplakia is recognized as an abnormal cellular response to chronic bacterial infection. Both patients were immunocompromised: one a cardiac transplant, the other a patient with Hodgkin’s disease. The lesions were focal and showed some response to antibiotic therapy, although other disease processes progressed in both patients. Malakoplakia should be added to the list of unusual infections occurring at unusual sites in compromised hosts

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“…The pathogenesis of malakoplakia remains unknown. Three possible pathogenetic mechanisms have been suggested: an unusual causative organism, an abnormal or altered immune response and an abnormal macrophage response due to defective lysosomal function [12] . Colonic malakoplakia was first described by Terner and Lattes in 1965 [13] and has been reported to occur in conjunction with tumors and non-tumoral conditions [14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

Karasavvidou¹,

Potamianos²,

Barbanis³

et al. 2007

WJG

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Malakoplakia, typically involving the urinary tract, is an uncommon form of chronic inflammation caused by chronic infections and characterized by accumulation of macrophages. It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph nodes, skin, respiratory tract, adrenal gland, vagina and brain. We present a case of a 64-year-old man referred to our hospital with cachexia and radiologic evidence of metastatic tumor of the liver. Colonoscopy revealed a large malignant -appearing polypoid mass of the ascending colon and multiple distinct polyps throughout the rest of the colon. Biopsies of the ascending colon mass confirmed the diagnosis of adenocarcinoma. Histological examination of two of the other polyps revealed malakoplakia which was characterized by aggregates of granular histiocytes with MichaelisGutmann bodies and histochemically confirmed with periodic acid-Schiff and von Kossa stains. This is a rare case diagnosed on endoscopic samples. The majority of reported cases were found in surgical specimens. In addition, the endoscopic appearance of multiple polyps is unusual in malakoplakia.

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“…The pathogenesis of malakoplakia remains unknown. Three possible pathogenetic mechanisms have been suggested: an unusual causative organism, an abnormal or altered immune response and an abnormal macrophage response due to defective lysosomal function [12] .…”

Section: Discussionmentioning

confidence: 99%

Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

Karasavvidou¹

2007

WJG

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Malakoplakia, typically involving the urinary tract, is an uncommon form of chronic inflammation caused by chronic infections and characterized by accumulation of macrophages. It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph nodes, skin, respiratory tract, adrenal gland, vagina and brain. We present a case of a 64-year-old man referred to our hospital with cachexia and radiologic evidence of metastatic tumor of the liver. Colonoscopy revealed a large malignant -appearing polypoid mass of the ascending colon and multiple distinct polyps throughout the rest of the colon. Biopsies of the ascending colon mass confirmed the diagnosis of adenocarcinoma. Histological examination of two of the other polyps revealed malakoplakia which was characterized by aggregates of granular histiocytes with MichaelisGutmann bodies and histochemically confirmed with periodic acid-Schiff and von Kossa stains. This is a rare case diagnosed on endoscopic samples. The majority of reported cases were found in surgical specimens. In addition, the endoscopic appearance of multiple polyps is unusual in malakoplakia.

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Clinical and laboratory studies into the pathogenesis of malacoplakia.

Abstract: Malacoplakia is an uncommon inflammatory disease that was originally described in the bladder (Michaelis and Gutmann, 1902;von Hansemann, 1903) but has subsequently been found in other genitourinary sites (Bleisch and

Cited by 84 publications

References 19 publications

Malakoplakia of the Lung

Malakoplakia of the Lung

Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

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