Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

Karasavvidou, F

doi:10.3748/wjg.13.6109

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…Although malakoplakia usually mimics malignancy, less than 30 cases of malakoplakia in association with adenocarcinoma of colon and rectum have been reported in English literature so far (9-12). Previous reports noted the possibility of over-estimating the pre-operative clinical stage of the disease, which can result in unsuitable treatment of the patients (9).…”

Section: Discussionmentioning

confidence: 99%

“…They showed that malakoplakia is usually found at the infiltrating border of the tumor without admixture with the neoplastic glands (11). Karasavvidou et al (12) reported a 64-year-old male patient with cachexia and radiological evidence of metastatic tumor of the liver. In colonoscopy a large malignant polypoid mass was identified in the colon along with multiple distinct polyps throughout the rest of the colon, which was in line with the findings of our reported case.…”

Section: Discussionmentioning

confidence: 99%

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Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report

Niknejad¹,

Nili²,

Shirkhoda³

2019

Iran J Pathol

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Malakoplakia is a rare granulomatous disease of the genitourinary system. Gastrointestinal tract is the second most common site of involvement. It usually mimics a malignancy but its association with adenocarcinoma has been rarely reported. A 59-year-old male patient with the history of weight loss and rectal bleeding for two months prior to administration was referred to our hospital. Pre-operative CT scan revealed a large sigmoid colon mass with the extension and invasion to the serosal surface as well as multiple regional metastatic lymph nodes. The patient underwent sigmoidectomy with the primary pathologic diagnosis of adenocarcinoma. Pathologic examination revealed a moderately differentiated adenocarcinoma invading peri-colic adipose tissue and inflammatory reaction compatible with malakoplakia at the invasive borders of the tumor with the extension to the serosal surface.In the patients with gastrointestinal malakoplakia, the presence of possible adjacent malignancy should be screened. The possibility of over-staging should also be considered for adenocarcinoma cases in association with malakoplakia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report

Niknejad¹,

Nili²,

Shirkhoda³

2019

Iran J Pathol

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“…However, several pathogenic mechanisms have been proposed, such as infection, immunosuppression (immune deficiency disorders and organ transplantation), systemic illness, neoplasia, and genetic disorder. Intriguingly, most of the cases reported have shown an association between systemic diseases and colorectal adenocarcinoma [2, 7, 8, 9]. …”

Section: Discussionmentioning

confidence: 99%

Colonic Malakoplakia: A Rare Finding in a Healthy Male

et al. 2018

Case Rep Gastroenterol

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Malakoplakia is a rare chronic granulomatous disease that may affect many organs, including the lung, brain, adrenal glands, pancreas, bone, and the genitourinary tract. The gastrointestinal tract is the most common site of involvement outside of the urinary tract. Herein, we present a case of a 65-year-old male who presented with abdominal pain and unintentional weight loss. Physical examination findings were unremarkable, but colonoscopy revealed an isolated large, flat, soft, and pale lesion in the transverse colon. Histopathological examination of the lesion showed expansion of the lamina propria due to numerous lymphocytes, plasma cells, neutrophils, and polygonal cells. Von Kossa stain showed small intracytoplasmic basophilic granular inclusions, and these histiocyte cells showed numerous Michaelis-Gutmann bodies, findings considered as diagnostic features of colonic malakoplakia. This is a rare case of isolated malakoplakia of the transverse colon diagnosed on endoscopic specimens. The majority of reported cases have shown an association between systemic diseases and colorectal adenocarcinoma. In addition, most reported cases of colonic involvement have been in the rectum, sigmoid, and right colon.

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“…Malakoplakia is notorious for mimicking a malignant neoplastic process. In fact, in a great majority of cases, the diagnosis first comes to light when a resection has been undertaken for the “malignant neoplasm.” Conversely malakoplakias have been reported to occur in association with adenocarcinomas including those of the colon and prostate [ 9 – 12 ]. Malakoplakia can pose significant challenges in staging of tumors as overstaging due to an overestimation of the size of the tumor may occur.…”

Section: Discussionmentioning

confidence: 99%

Malakoplakia of the Pancreas with Simultaneous Colon Involvement: Case Report and Review of the Literature

Guha

Liu

2015

Case Reports in Pathology

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Although malakoplakia has been reported to occur at various body sites, pancreatic malakoplakia with simultaneous colonic involvement is very rare. Lesions of malakoplakia can masquerade as tumor masses leading to unwanted resections. Nevertheless, malakoplakia can occur in association with frank carcinomas, especially in the colon. By reporting a case of pancreatic malakoplakia diagnosed by fine needle aspiration cytology, this paper aims to describe cytologic features of malakoplakia and to further review findings from previous reported cases of pancreatic malakoplakia in the literature. With advances in minimally invasive, image-guided aspiration technologies, cytomorphological analyses can diagnose lesions of malakoplakia. This may help avoid surgeries that would have otherwise been carried out due to a misleading impression of tumor. However challenges remain as to the further management of patients diagnosed with this condition. More studies are necessary to determine the probability of malignancies arising in association with malakoplakia, in order to devise appropriate treatment protocols.

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Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies

Cited by 8 publications

References 6 publications

Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report

Malakoplakia in Association with Adenocarcinoma of Sigmoid Colon; A Case Report

Colonic Malakoplakia: A Rare Finding in a Healthy Male

Malakoplakia of the Pancreas with Simultaneous Colon Involvement: Case Report and Review of the Literature

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