Clinical and Laboratory Markers of Bacterial Infection in Children of Different Ages

Ovsyannikov, D.Yu.; Кузьменко, Л. Г.; Nazarova, T.I.; Haled, M.; Фролов, П А; Nguen, B.V.; Illarionova, T.Yu.; Semyatov, S.M.; Eliseeva, T.I.

doi:10.24110/0031-403x-2019-98-1-186-192

Cited by 7 publications

(5 citation statements)

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“…При анализе клинической картины заболевания и результатов обследований обращают на себя внимание доминирование в клинической картине симптомов дыхательной недостаточности, двустороннего поражения легких, бронхиальной обструкции, включая крепитацию, возникающую, вопреки распространенному мнению, при слипании и разлипании не альвеол, а бронхиол; отсутствие лихорадки, лабораторных маркеров бактериальной инфекции, лимфоцитоз и моноцитоз в общем клиническом анализе крови, что характерно для ОБ [3,9,37]. В общем клиническом анализе также обращали на себя внимание тромбоцитоз и эозинофилия.…”

Section: Discussionunclassified

Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus

Ovsyannikov¹,

Tsverava²,

Krsheminskaya³

et al. 2022

Neonatology: News, Opinions, Training

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В статье представлено клиническое наблюдение недоношенного ребенка с бронхолегочной дисплазией, перенесшего тяжелый острый бронхиолит (ОБ), вызванный респираторно-синцитиальным вирусом (РСВ). Приведены сведения об эпидемиологии, этиологии, диагностике, терапии ОБ, пассивной иммунопрофилактике РСВ-инфекции с помощью паливизумаба, количестве его назначений в Москве, эффективности паливизумаба для профилактики инфекций нижних дыхательных путей, вызванных РСВ. Проведен подробный анализ течения, клинических, лабораторных и рентгенологических данных, терапии РСВ-ОБ у наблюдавшегося пациента с сопоставлением с современными данными литературы.Финансирование. Работа не имела спонсорской поддержки. Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.

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Section: Discussionunclassified

Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus

Ovsyannikov¹,

Tsverava²,

Krsheminskaya³

et al. 2022

Neonatology: News, Opinions, Training

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“…Criteria for inclusion were a diagnosis of BA, made in accordance with current international and national conciliatory documents, and the presence of nasal or sinonasal complaints and symptoms in patients ( 1 ). Exclusion criteria were: acute infectious diseases and fever, diabetes, autoimmune disorders, primary immunodeficiency, and cancer, as well as oral glucocorticoid intake ( 38 ). The diagnosis of BA and the severity of the disease were established by the attending physician in accordance with the recommendations available at that time (GINA 2017-2019) ( 1 ).…”

Section: Methodsmentioning

confidence: 99%

The Relationship Between Indicators of Nasal Respiratory Function and Spirometric Parameters in Children With Bronchial Asthma

et al. 2021

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Introduction: The relationship between objective indicators of nasal obstruction and airflow limitation in children with bronchial asthma (BA) and allergic rhinitis (AR) has not yet been studied.Objective: To study the relationship between objective parameters of nasal obstruction and airflow limitation, determined using the methods of anterior active rhinomanometry (AARM) and spirometry in children with BA and AR.Materials and Methods: Eighty eight children and adolescents with BA and AR, boys−65.9% (58/88), were examined. The median age was 11.09 [10.42; 11.76] years. To determine airflow limitation, the following spirometric parameters were evaluated: forced vital capacity of the lungs (FVC), forced expiratory volume in 1 s (FEV1), the ratio of FEV1/FVC, and maximum expiratory flow at the point 25% of the flow-volume loop (MEF25). Data were recorded both in absolute values and in relative units (% pred). Nasal respiratory function was determined by AARM based on the total nasal airflow (TNAF) in absolute (Pa/cm3/s) and relative units (RTNAF, % pred).Results: In the general cohort and in boys but not in girls, a statistically significant direct correlation was found between TNAF (Pa/cm3/s) and absolute spirometry parameters of bronchial patency—all had p < 0.01. Also, RTNAF and relative MEF25 values (% pred) in the general cohort were R = 0.22, p = 0.04, and in boys, R = 0.28, p = 0.03. In girls, there was no statistically significant correlation between nasal respiratory function and spirometric parameters, all p > 0.05. Additional analysis of literature was conducted to ascertain that the identified gender differences were not occasional.Conclusion: The significant positive correlation of absolute values of AARM and spirometric parameters in children with BA and AR was established, which apparently reflects the physical development of children. Of all the relative indicators of spirometry, only MEF25 (% pred), which indirectly reflects the patency of small bronchi, had a distinct direct correlation with RTNAF. These patterns are clearly expressed in boys with BA. In girls with this disease, however, the relationship between nasal respiratory function and spirometric indicators seems to be more complex and requires further study.

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“…The study inclusion criterion was the diagnosis of asthma made in accordance with the current international and national recommendations [ 1 ]. The exclusion criteria were acute infectious diseases, fever, diabetes mellitus, autoimmune disorders, primary immuno-deficiencies, oncological diseases, and oral administration of glucocorticoids [ 37 ]. The diagnosis and severity of asthma were determined by the attending physician according to the GINA recommendations available at that time [ 1 ].…”

Section: Methodsmentioning

confidence: 99%

Periostin as a Biomarker of Allergic Inflammation in Atopic Bronchial Asthma and Allergic Rhinitis (a Pilot Study)

Krasilnikova¹,

Tush²,

Frolov³

et al. 2020

Sovrem Tehnol Med

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The involvement of periostin in Th2-dependent allergic inflammation has been documented. However, the significance of periostin as a biomarker of local allergic inflammation in the nasal mucosa (NM) of patients with atopic bronchial asthma (BA) and allergic rhinitis (AR) is yet to be determined. The aim of the study was to determine the presence of periostin and evaluate its role as a non-invasive marker of allergic inflammation in the nasal secretions of children with atopic BA and AR. Materials and Methods. In 43 patients aged 4–17 years with atopic BA and AR, the NM was examined using nasal video-endoscopy and (if indicated) computed tomography; the amount of periostin in the nasal secretion was determined by the enzyme immunoassay. Results. Exacerbation of AR was accompanied by a statistically significant increase in the level of periostin in the nasal secretion: up to 0.84 [0.06; 48.79] ng/mg, whereas in remission, that was 0.13 [0.00; 0.36] ng/mg; p=0.04. This value increased progressively as the severity of AR increased from 0.16 [0.00; 0.36] ng/mg in the mild course to 0.20 [0.00; 9.03] ng/mg in AR of moderate severity, and to 10.70 [0.56; 769.20] ng/mg in most severe cases; p=0.048. Hypertrophy or polyposis of the nasal and/or paranasal mucosa was detected in 34.9% (15/43) of the examined patients. The concentration of periostin in the nasal secretion was lower in children without NM hypertrophy: 0.18 [0.001; 4.30] ng/mg vs 0.78 [0.13; 162.10] ng/mg in patients with NM hypertrophy; the differences were close to statistically significant: p=0.051. The level of nasal periostin depended on the clinical form of hypertrophy in the sinonasal mucosa, reaching 0.17 [0.00; 0.32] ng/mg in children with polyposis hyperplasia of NM and 21.6 [10.70; 1516.80] ng/mg — with hypertrophy of the NM in the medial surface of the concha; p=0.02. Conclusion. Exacerbation and increased severity of AR in patients with atopic BA are accompanied by an increased level of periostin in the nasal secretion. This allows us to consider the level of nasal periostin as a biomarker of local allergic inflammation in the NM of patients with atopic BA combined with AR. Hypertrophic changes in the sinonasal mucosa are generally accompanied by an increased level of nasal periostin; specifically, this level significantly depends on the clinical form of mucous membrane hypertrophy and requires additional studies.

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Clinical and Laboratory Markers of Bacterial Infection in Children of Different Ages

Cited by 7 publications

References 0 publications

Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus

Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus

The Relationship Between Indicators of Nasal Respiratory Function and Spirometric Parameters in Children With Bronchial Asthma

Periostin as a Biomarker of Allergic Inflammation in Atopic Bronchial Asthma and Allergic Rhinitis (a Pilot Study)

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