Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus

Ovsyannikov, D.Yu.; Tsverava, A.G.; Krsheminskaya, I.V.; Tsygankov, A. E.; Mikheeva, A.A.; Berezhanskiy, P.V.; Miroshnichenko, V.P.; Sigova, Yu.A.; Nikolishin, A.N.; Горев, В.В.

doi:10.33029/2308-2402-2022-10-4-63-74

Neonatology: News, Opinions, Training

2022

DOI: 10.33029/2308-2402-2022-10-4-63-74

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Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus

D.Yu. Ovsyannikov¹,

A.G. Tsverava²,

I.V. Krsheminskaya³

et al.

Abstract: В статье представлено клиническое наблюдение недоношенного ребенка с бронхолегочной дисплазией, перенесшего тяжелый острый бронхиолит (ОБ), вызванный респираторно-синцитиальным вирусом (РСВ). Приведены сведения об эпидемиологии, этиологии, диагностике, терапии ОБ, пассивной иммунопрофилактике РСВ-инфекции с помощью паливизумаба, количестве его назначений в Москве, эффективности паливизумаба для профилактики инфекций нижних дыхательных путей, вызванных РСВ. Проведен подробный анализ течения, клинических, лабора… Show more

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Severe acute bronchiolitis in children: etiology, therapy, effectiveness of 3% hypertonic saline containing sodium hyaluronate

Tsygankov¹,

Ovsyannikov

Ivanova³

et al. 2023

Medicinskij sovet

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Introduction. Acute bronchiolitis (АB) is a common infection in children under the age of 2 years. In modern clinical protocols, routine use of the studied drugs is not recommended. The effectiveness of a 3% hypertonic sodium chloride solution (HSCS) at vol.Аim. Тo study the etiology, risk factors, the therapy of acute care in children in intensive care units (ICU), the effectiveness of inhalations with 3% HSCS with hyaluronate sodium (HS) in comparison with therapy without the inclusion of this drug.Materials and methods. The medical documentation of 54 patients with AB from January 2021 to January 2023 who were treated in the ICU was analyzed. An ambispective comparative study of the effectiveness of therapy of 3% HSCS with HS AB was conducted in comparison with historical control.Results. Respiratory syncytial viral (RSV) etiology was established in 50% of patients. The most common risk factor for the disease was the age younger than 3 months (40.7%). The presence of risk factors for severe course of acute respiratory failure had an impact on the average bed-day and on the need for respiratory support (p = 0.04), in addition to which patients often received drug therapy. There were no statistically significant differences in the terms of hospitalization, the duration of respiratory support depending on the appointment of 3% of HSCS with HS (p > 0.05), however, there was an improvement in clinical and functional dynamics estimated by the modified clinical scale of Wood’s asthma by the 2nd day of the disease.Conclusion. AB in ICU patients most often has RSV etiology, developing in the presence of risk factors for severe course. The influence of modern guidelines for the treatment of AB in the ICU remains controversial. The addition of 3% HSCS with HS can improve the flow of AB.

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Severe acute bronchiolitis in children: etiology, therapy, effectiveness of 3% hypertonic saline containing sodium hyaluronate

Tsygankov¹,

Ovsyannikov

Ivanova³

et al. 2023

Medicinskij sovet

Self Cite

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Dynamics of Changes in the Acid-Base Status Parameters as the Main Method of Controlling Treatment of Bronchopulmonary Dysplasia: A Clinical Case)

Alekseeva,

Makarova,

Kapitonova

et al. 2024

jour

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Аннотация. В статье описан случай развития тяжелой формы бронхолегочной дисплазии у недоношенного новорожденного.В мире каждый год около 15 миллионов детей рождаются на свет преждевременно. В среднем 1 ребенок из 10 появляется на свет недоношенным. В России ежегодно более 110 тысяч детей рождаются раньше срока, т.е. около 5,7 % от числа всех новорожденных за год. [8] Этим подтверждается актуальность выбранной темы.Анализ КЩС относится к категории экспресс исследований, поскольку его параметры быстро изменяются при любых сдвигах состояния пациента (показателей дыхания, температуры тела, физической активности, функции почек и т. д.) [9].При исследовании рН крови выявлен субкомпенсированный метаболический ацидоз. Газовый состав крови изменяется от гипокапнии до гиперкапнии, что свидетельствует о тяжелой степени дыхательной недостаточности с картиной гиповентиляции легких у недоношенных новорожденных. Выявленное снижение электролитов связано с проведением мочегонной и стероидной терапии у больных с бронхолегочной дисплазией. Из-за недоношенности компенсаторные механизмы оказались недостаточны для поддержания гомеостатических параметров (рН, газовый и электролитный состав крови).При проведении оксигенотерапии аппаратом ИВЛ необходимо руководствоваться динамикой анализов КОС для калибровки параметров аппарата и корректировки инфузионной терапии.

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Patients with bronchopulmonary dysplasia are at risk of severe bronchiolitis caused by respiratory syncytial virus

Cited by 2 publications

References 6 publications

Severe acute bronchiolitis in children: etiology, therapy, effectiveness of 3% hypertonic saline containing sodium hyaluronate

Severe acute bronchiolitis in children: etiology, therapy, effectiveness of 3% hypertonic saline containing sodium hyaluronate

Dynamics of Changes in the Acid-Base Status Parameters as the Main Method of Controlling Treatment of Bronchopulmonary Dysplasia: A Clinical Case)

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