Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever

Lichtenstein, Lawrence M.; Norman, Philip S.; Winkenwerder, Walter L.

doi:10.1016/0002-9343(68)90052-1

Cited by 170 publications

(60 citation statements)

References 20 publications

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“…The physician's evaluation has been previously shown to correlate with the symptom scores reported by the patients (15,18). We have found that the patients' symptom scores correlate better with both the pollen count and cell sensitivity measurements than do physician scores (15,18). We have, therefore, presented only the former.…”

Section: Introductionmentioning

confidence: 96%

“…Daily symptom scores obtained in this way have been shown previously to be highly correlated with the daily ragweed pollen count (15,18,19). The scores were also averaged to yield a single number reflecting the clinical severity of the ragweed season for a single patient; these scores have previously been shown to correlate significantly with the patient's cell sensitivity measurements (15,18). Each patient was evaluated bi-weekly by a physician who was not aware of the patient's therapeutic regimen.…”

Section: Introductionmentioning

confidence: 99%

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IgE Antibody Measurements in Ragweed Hay Fever RELATIONSHIP TO CLINICAL SEVERITY AND THE RESULTS OF IMMUNOTHERAPY

Lichtenstein¹,

Ishizaka²,

Norman³

et al. 1973

J. Clin. Invest.

325

129

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A B S T R A C T Specific IgE anti-ragweed antibodies (IgEAR) were measured over two years in two groups of highly sensitive patients treated (immunized) with either ragweed extract or placebo and in a third group of placebo-treated, relatively insensitive patients. TheIgEAR on the patients' basophils were assessed by ragweed antigen E (AgE)-induced histamine release; blocking (IgG) antibodies were measured by their ability to inhibit AgE induced histamine release. These data were evaluated against the clinical severity of ragweed hay fever in each patient.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

IgE Antibody Measurements in Ragweed Hay Fever RELATIONSHIP TO CLINICAL SEVERITY AND THE RESULTS OF IMMUNOTHERAPY

Lichtenstein¹,

Ishizaka²,

Norman³

et al. 1973

J. Clin. Invest.

325

129

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“…Cells of the treated subjects become less sensitive or less reactive to ragweed antigen E (AgE) (6,7), and IgG antibodies ("blocking" antibodies) appear in the serum (8)(9)(10). The apparent suppression of IgE antibody has been attributed to the presence of IgGblocking antibody (6).…”

Section: Introductionmentioning

confidence: 99%

Seasonal Changes in IgE Antibodies and Their Relationship to IgG Antibodies during Immunotherapy for Ragweed Hay Fever

Yunginger¹,

Gleich²

1973

J. Clin. Invest.

109

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“…These data also show that basophils from patients with respiratory allergy are more prone to release histamine spontaneously or in response to anti-IgE, FMLP and IL-3 than basophils from healthy subjects. This finding may have a clinical relevance, since it has been demonstrated that the severity of allergic symptoms is correlated with basophil sensitivity to antigen stimulation in vitro [8].…”

Section: Discussionmentioning

confidence: 58%

“…Basophil releasability is increased in patients with allergic rhinitis and asthma [5][6][7], and it has been suggested that it may contribute to the pathogenesis of allergic disease. LICHTENSTEIN and co-workers [8] showed that the severity of symptoms in allergic patients during the ragweed season correlated with basophil sensitivity to antigen stimulation in vitro. A correlation has been found between basophil number in peripheral blood and bronchial hyperresponsiveness as assessed by methacholine challenge in asthmatic patients [9]; therefore, the enhanced basophil releasability that has been observed in patients with respiratory allergy may be of clinical significance.…”

mentioning

confidence: 99%

Defective inhibition of sodium on basophil histamine release in patients with allergic rhinitis and bronchial asthma

Tedeschi¹,

Cottini²,

Salmaso³

et al. 1996

Eur Respir J

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D De ef fe ec ct ti iv ve e i in nh hi ib bi it ti io on n o of f s so od di iu um m o on n b ba as so op ph hi il l h hi is st ta am mi in ne e r re el le ea as se e i in n p pa at ti ie en nt ts s w wi it th h a al ll le er rg gi ic c r rh hi in ni it ti is s a an nd d b br ro on nc ch hi ia al l a as st th hm ma a A. Tedeschi*, M. Cottini**, C. Salmaso*, N. Milazzo*, A. Miadonna* Defective inhibition of sodium on basophil histamine release in patients with allergic rhinitis and bronchial asthma. A. Tedeschi, M. Cottini, C. Salmaso, N. Milazzo, A. Miadonna. ©ERS Journals Ltd 1996. ABSTRACT: The aim of this study was to evaluate whether Na + exerts its inhibitory effect on basophil histamine release induced by immunoglobulin E (IgE)-dependent (anti-IgE) and IgE-independent (N-formyl-methionyl-leucyl-phenylalanine (FMLP), interleukin-3 (IL-3)) stimuli in patients with allergic rhinitis (n=24) and allergic bronchial asthma (n=10). Peripheral blood leucocytes were stimulated with anti-IgE, FMLP and IL-3 in the presence of high and low Na + concentrations, and histamine release was measured using a fluorometric method.In standard Na + -containing medium, spontaneous and stimulated histamine release was higher in allergic patients (n=34) (both rhinitic and asthmatic) than in healthy subjects (n=41). Na + removal from extracellular medium and its isosmotic substitution with choline chloride or with N-methyl-D-glucamine led to a significant increase of anti-IgE-, FMLP-and IL-3-induced histamine release in normal subjects, but not in allergic patients. The increase in Na + concentration in the extracellular medium was accompanied by a dose-dependent decrease of anti-IgE-and FMLP-induced histamine release in normal subjects, but not in allergic patients. The behaviour of atopics and healthy subjects was different and not related to the basophil responsiveness to activating signals. The incubation of basophils from healthy subjects with sera from allergic patients did not have a significant influence on the inhibitory effect of Na + .Basophils from healthy subjects and atopic patients respond differently when stimulated in a low Na + medium. The reduced sensitivity to the inhibitory effect of Na + may contribute to basophil dysfunction in patients with respiratory allergy.

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Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever

Cited by 170 publications

References 20 publications

IgE Antibody Measurements in Ragweed Hay Fever RELATIONSHIP TO CLINICAL SEVERITY AND THE RESULTS OF IMMUNOTHERAPY

IgE Antibody Measurements in Ragweed Hay Fever RELATIONSHIP TO CLINICAL SEVERITY AND THE RESULTS OF IMMUNOTHERAPY

Seasonal Changes in IgE Antibodies and Their Relationship to IgG Antibodies during Immunotherapy for Ragweed Hay Fever

Defective inhibition of sodium on basophil histamine release in patients with allergic rhinitis and bronchial asthma

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