Seasonal Changes in IgE Antibodies and Their Relationship to IgG Antibodies during Immunotherapy for Ragweed Hay Fever

Yunginger, John W.; Gleich, Gerald J.

doi:10.1172/jci107294

Cited by 109 publications

(48 citation statements)

References 19 publications

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“…The data presented here have clearly shown that the serum concentration of both total IgE and IgE antibodies increases dur ing the pollen season in patients with polleninduced allergic rhinits, which is in accord with previous reports [3,18,25]. The prob able explanation for these serum changes is that allergen stimulation in patients with pollen-induced allergic rhinitis provokes an increase in the production of reagins, which raises the level of both IgE antibodies and total IgE in serum.…”

Section: Discussionsupporting

confidence: 92%

“…Nakajima et al [15] have in fact found support in their studies for the concept that such a process might explain certain differences between IgE and IgA in external secretion. Previous investigations [3,25,26] re vealed that in patients with pollen-induced allergy, the serum levels of both IgE and re agins were raised not only during the pollen season itself but also weeks or months after exposure to pollen had ceased. Our results showed that IgE and IgE antibodies in the serum and nasal secretion were distinctly in creased as long as 6 weeks after the end of the pollen season, in comparison with the pre-season values.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Immunoglobulins in Nasal Secretion with Special Reference to IgE

Deuschl¹

1976

Int Arch Allergy Immunol

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14 adult patients with allergic rhinitis due to timothy pollen were observed for 13 weeks during the grass pollen season. IgE, IgA and timothy-specific IgE antibodies could be quantified in all serum and secretion samples. Total IgE and specific IgE antibodies in both serum and secretion reached significantly higher levels in samples taken during and after the pollen season than before the season. These seasonal changes proved to be significantly more pronounced in nasal secretion than in serum. An indication of local production in the nasal mucosa of IgE, IgA and specific IgE antibodies was also found.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Immunoglobulins in Nasal Secretion with Special Reference to IgE

Deuschl¹

1976

Int Arch Allergy Immunol

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“…These dis crepancies between the methods are not eas ily explained. Thus, in agreement with in vestigations by others [13,14,33], this study does not give much support for the view that the blocking antibodies affect the RAST results. It should be noted, however, that there are some important methodologi cal differences between the two methods.…”

Section: Discussionsupporting

confidence: 74%

“…Later the IgE levels often decline while the IgG antibody levels remain raised [14,17,18,33], This pattern was seen in this study, al though the increases were not very pron ounced and many patients did not exhibit any changes of their antibody levels at all.…”

Section: Discussionsupporting

confidence: 58%

Immunotherapy in Atopic Allergy – Antibody Titres and Avidities during Hyposensitization with Birch and Timothy Pollen Allergens

Ahlstedt¹,

Eriksson²

1977

Int Arch Allergy Immunol

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The quantities and the avidities of antibodies against birch pollen and, in some sera, timothy pollen were studied in atopic patients during the course of hyposensitization therapy with aqueous or Allyral allergen extracts. The ammonium-sulphate precipitation (ASP) technique was used to determine the allergen-binding capacity of the sera before and after absorption with anti-human IgE antibodies conjugated to Sepharose. Furthermore, IgE antibodies were determined with the radioallergosorbent test (RAST). IgE as well as non-IgE antibody titres increased after initiation of immunotherapy but after 2–3 years of treatment the IgE antibodies decreased, according to RAST results. No consistent pattern of increase or decrease of antibody titres was seen during the pollen seasons. However, a decrease of RAST values as well as of non-IgE titres determined with the ASP technique was found between the post-season sera from the first year of therapy and the pre-season sera the following year in respect of birch pollen allergen. No significant changes of antibody avidities were seen, nor could any significant correlations be found between the patients symptom scores during the birch pollen season and the antibody titres or avidities. The findings were similar for timothy pollen. It is concluded that the improvement of reagin-mediated symptoms found during immunotherapy is not caused by changes in the amounts or avidities of the specific antibodies detectable in the serum with the methods mployed, but other factors have to be sought.

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“…10 of these had a history of ragweed hay fever and positive immediate skin tests to short ragweed extract. Analyses of the sera of these patients showed that each had significant levels of IgE antibodies to short ragweed, as measured by the radioallergosorbent test (RAST) (8,9). 5 of the 10 subjects in the ragweed group had received maintenance hyposensitization to ragweed pollen extract for at least the previous 12 mo.…”

Section: Methodsmentioning

confidence: 99%