Clinical and immunological impact of early postoperative enteral immunonutrition after total gastrectomy in gastric cancer patients: A prospective randomized study

Enteral Nutrition versus Parenteral Nutrition after Major Abdominal Surgery in Patients with Gastrointestinal Cancer: A Systematic Review and Meta-Analysis

“…However, a more recent meta-analysis by Bozzetti et al 48 showed nutritional support, in general, that included IEEN, EN, and TPN, yielded a clinical benefit by reducing infectious complications in high-risk or malnourished patients. Marano et al 49 have attempted to explain the discrepancies in findings regarding EN versus TPN in such studies based on the differences in patient groups studied. According to their analysis, those studies that reported no clinical effect of nutritional intervention were usually performed on well-nourished patients, whereas the findings of beneficial effects (reduction in complications) from nutritional support included moderately to severely malnourished patients8 49…”

“…Marano et al 49 have attempted to explain the discrepancies in findings regarding EN versus TPN in such studies based on the differences in patient groups studied. According to their analysis, those studies that reported no clinical effect of nutritional intervention were usually performed on well-nourished patients, whereas the findings of beneficial effects (reduction in complications) from nutritional support included moderately to severely malnourished patients8 49…”

The potential benefits and harms of early feeding post‐surgery: a literature review

“…Some literature focuses on the role of immuno‐nutrition to aid wound healing ; for example, arginine is found to improve healing, support immune function and is specifically needed for collagen synthesis , while omega‐3 and RNA are needed during cell signalling . Farreras et al .…”

“…Three decades ago, Haydock and Hill identified a relationship between the nutritional status of patients undergoing surgery and wound healing, with those who were well‐nourished having better wound healing than those suffering malnutrition. This evidence has helped researchers to identify ways to ameliorate nutrition during postoperative care , with subsequent studies emerging on the effects of different types and routes of the early feeding (EF) postoperatively . Initiatives, such as enhanced recovery after surgery (ERAS), have been introduced to accelerate recovery time after surgery .…”

Enteral immunonutrition in gastric cancer

“…Sparse evidences published reveal a beneficial of facilitating recovery of patients undergoing the gastrectomy from surgery in enteral immunonutrition (EIN) regime group, [3,4] but there are some studies support standard enteral nutrition (SEN) to be as the nutrition support for patients undergoing surgery for GC. [2] So which nutrition support regimes can be selected to be as the preferred option for GC patients undergoing gastrectomy is still an issue.…”