Clinical and immunologic aspects of egg donation pregnancies: a systematic review

Hoorn, Marie-Louise van der; Lashley, Eileen; Bianchi, D. W.; Claas, Frans H.J.; Schonkeren, C. M. C.; Scherjon, Sicco A.

doi:10.1093/humupd/dmq017

Cited by 125 publications

(75 citation statements)

References 69 publications

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“…OD pregnancy is associated with an elevated risk of gestational hypertension and preeclampsia [6,42,46,76]. Metaanalysis of data on 86,515 OD pregnancies has revealed a higher risk of preeclampsia (odds ratio 2.54 compared with ART, odds ratio 4.34 compared with natural conception) and gestational hypertension (odds ratio 3.00 compared with ART, odds ratio 7.94 compared with natural conception) [42].…”

Section: Introductionmentioning

confidence: 99%

A new era in reproductive medicine: consequences of third-party oocyte donation for maternal and fetal health

et al. 2016

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The fetus is a semi-allograft for the maternal host in natural pregnancy, but the fetus is a complete allograft after oocyte donation (OD), and there is greater antigenic dissimilarity with the mother. Thus, OD pregnancy is a good model for understanding how the fetus is protected by the maternal immune system. Recent clinical data have revealed a higher risk of miscarriage, gestational hypertension, preterm birth, and low birth weight with OD pregnancy. There is also a higher incidence of chorionic deciduitis, dense fibrinoid deposits in the chorionic basal plate, inflammatory lesions in the chorionic plate, and C4d deposition on syncytiotrophoblasts in OD pregnancy. Impaired accumulation of T cells, regulatory T (Treg) cells, natural killer (NK) cells, and monocytes in the decidua basalis and poor remodeling of spiral arteries are observed in OD pregnancy irrespective of whether preeclampsia occurs. These findings may partly explain why OD pregnancy is associated with a high risk of gestational hypertension and preeclampsia. We need to clarify the immunological and pathological differences between uncomplicated and complicated OD pregnancy. In uncomplicated OD pregnancy, the level of HLA match between mother and baby is significantly higher than would be expected by chance, suggesting that miscarriage may be frequent with marked HLA mismatch. This review discusses the relationship between various aspects of the immune system and complications of OD pregnancy.

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Section: Introductionmentioning

confidence: 99%

A new era in reproductive medicine: consequences of third-party oocyte donation for maternal and fetal health

et al. 2016

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“…Oocyte recepients tended to deliver 2.4 weeks before the control population and with removal of multiple gestations from the data the recipients still delivered 1.28 weeks earlier [6].…”

Section: Few Of the Conditions Encountered In Such Pregnancies Are Comentioning

confidence: 87%

“…Klatsky et al [5] identified increased risk of preeclampsia in oocyte recepients, 4.9% versus 16.9% [6]. This adversely affects the fetus with complications like IUGR, Oligohydramnios and fetal hypoxia.…”

Section: Few Of the Conditions Encountered In Such Pregnancies Are Comentioning

confidence: 99%

“…Compared with spontaneously conceived pregnancies there is a higher degree of antigenic dissimilarity in Donor egg pregnancies. Since ED pregnancies are characterized by more number of HLA mismatches it is to be expected that a possible relationship between aspects of immune regulation and the number of HLA mismatches will become more apparent in Donor egg pregnancies [6].…”

Section: Immune Considerations In Ed Pregnanciesmentioning

confidence: 99%

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Pregnancy Outcomes in Donor Oocyte Conceptions

Saple¹,

Agrawal²

2016

IPCB

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“…Although there are few studies on the longterm outcome of pregnancies with third-party eggs, there is a demonstrated increased risk of complications for the mother. 6 …”

Section: Whose Interests?mentioning

confidence: 99%

Babies, Borders and Big Business

Cottingham¹

2017

Reproductive Health Matters

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Clinical and immunologic aspects of egg donation pregnancies: a systematic review

Cited by 125 publications

References 69 publications

A new era in reproductive medicine: consequences of third-party oocyte donation for maternal and fetal health

A new era in reproductive medicine: consequences of third-party oocyte donation for maternal and fetal health

Pregnancy Outcomes in Donor Oocyte Conceptions

Babies, Borders and Big Business

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