Clinical and imagiological findings of central giant cell lesion and cherubism

Abstract

Cone beam computed tomography (CBCT) is the best examination for bone lesions of the maxilla, allowing the dentist to evaluate precisely the behavior and components of the lesion and their relationship to the surrounding structures. Central giant cell lesion and cherubism are histologically very similar lesions. Therefore clinical and radiological examinations are fundamentally important for the diagnosis. The aim of this paper is to report two cases diagnosed as central giant cell lesions and cherubism using CBCT. This imaging modality was very important for the diagnosis of the lesions presented in the current study. It also allowed observing precisely the limits of the lesions, the components, the behavior and the exact relationship to adjacent structures.

Treatment of an aggressive central giant cell lesion

“…These data are important to establish a better prognosis and treatment planning. CT, in the other hand, shows precisely the limits of the lesions, their components, behavior, the exact relation with surrounding structures, [10] as seen in this case.…”

Cherubism: Case Report and Review of the Literature

“…25,26 CBCT is very useful tool for the assessment of lesion dimensions, precisely the limits of the lesions, their components, behavior and the exact relation with surrounding structures in cherubism. 27 In our case, CBCT images showed bilateral, large, expansile, multilocular osteolytic lesions with expansion and perforation of the cortical bone at the angle and ramus of the mandible.…”

Cherubism With Bilateral Mandible and Maxilla Involvement

“…Swelling of the jaws usually occurs between 1 and 7 years of age, most often between 12 and 36 months, 5,11,13 with men affected more commonly than women. 7,14,15,16 In this case, the patient showed symptoms of the disorder at the age of 2 years. Lesions increase in number and size until puberty, when they typically begin to regress, fill with bone and remodel until approximately 30 years of age when they often become undetectable.…”

“…In most patients, cherubism is because of dominant mutations in the SH3BP2 gene on chromosome 4p16.3. 6,7,8,9 In addition to genetic factors, Caballero and Vinals 10 indicated other possible causes of cherubism, such as mesenchymal alterations during jaw development, an odontogenic origin or even hormonal and traumatic factors.…”