Clinical and imaging analysis of subclinical hemophilia combined with coxarthrosis: case report and literature review

Abstract

IntroductionThe incidence of subclinical hemophilic arthritis is low, with this case reports and literature review, we hope clinicians could pay more attention to the diagnosis of subclinical hemophilic arthritis and prevent the misdiagnosis and mistreatment.Case presentationWe analyzed the imaging feature, and therapy of a subclinical hemophilia case with hip lesion by reporting its clinical manifestations, imaging features and therapy procedure, and reviewing literatures.ResultsHemophilia is a sex-linked recessive hereditary hemorrhagic disease, and the pathogenesis of subclinic hemophilia is concealed, which often involves joint lesion. The imaging of joint lesion of hemophilia cases is typical, which facilitates the differential diagnosis with other joint diseases. The current treatment is mainly supplementary or replacement therapy.ConclusionHemophilic arthritis cases, especially the mild or subclinical cases without family history and with an older age of onset, are not common. The disease should be further understood, and early diagnosis and treatment is crucial to prevent the progressive development of joint diseases.

Clinical assessments and gait analysis for patients with Trimalleolar fractures in the early postoperative period

“…Van Hoeve, S et al [ 4 ] found that compared with the healthy subjects (12.59 ± 3.73 ), the ROM during gait in patients (7.13 ± 2.55 ) with trimalleolar ankle fractures decreased significantly. After ankle fractures, the uncoagulated hemorrhage leads to the rapid increase of intra-articular pressure, which causes abrupt joint swelling, pain and limited mobility [ 24 ]. Presence of soft tissue damages such as tendon and ligamental injuries can cause chronic swelling and stiffness therefore resulting in the dismal outcome [ 3 ].…”

Clinical Assessments and Gait Performance in Patients with Trimalleolar Fractures

“…van Hoeve, S et al [4] found that compared with the healthy subjects (12.59 ̊ ± 3.73 ), the ROM during gait in patients (7.13 ̊ ± 2.55 ) with trimalleolar ankle fractures decreased signi cantly. After ankle fractures, the uncoagulated hemorrhage leads to the rapid increase of intra-articular pressure, which causes abrupt joint swelling, pain and limited mobility [24]. Presence of soft tissue damages such as tendon and ligamental injuries can cause chronic swelling and stiffness therefore resulting in the dismal outcome [3].…”

Hemofilia: abordaje diagnóstico y terapéutico

“…La principal manifestación clínica de la hemofilia es la hemorragia, cuyo grado depende del nivel del factor viii o ix presente en el plasma, usualmente secundaria a traumas en sitios de localización profunda, como articulaciones, músculos y sistema nervioso central (snc), a diferencia de otras coagulopatías, como la enfermedad de von Willebrand y disfunciones plaquetarias donde el sangrado predomina en mucosas [3,13].…”