Clinical and Histopathological Analysis of the Kidney Biopsies of 2,450 Patients seen over 30 Years at Chungnam National University Hospital

Bae, Hong Jin; Moon, Kang Ryun; Kim, Ye Jin; Choi, Dae Eun; Na, Ki Young; Lee, Kang Wook; Shin, Young Tai

doi:10.3904/kjm.2013.84.3.379

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Our findings were similar to the reports from other South Asian countries, America, Egypt, Spain and Iran, where the most common diagnosis was FSGS [ 13 , 15 – 22 , 35 – 38 ], Other studies from Europe, East Asia and Australia showed conflicting findings where they reported IgAN to be the most prevalent histopathological diagnosis [ 6 – 12 , 14 , 39 – 45 ]. Nevertheless, some studies in South Asia had different results as well, where they reported MCD [ 46 , 47 ] and DPGN [ 29 ] as the most frequent diagnosis.…”

Section: Discussionsupporting

confidence: 90%

Clinicopathological spectrum of biopsy-proven renal diseases of patients at a single center in Sri Lanka: a cross sectional retrospective review

et al. 2023

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Background The clinical presentation of renal diseases can vary widely. The lack of a comprehensive national registry for Sri Lanka makes it difficult to provide a detailed record of the various clinical presentations and histopathology of renal disorders in the nation. Therefore, this study aims to provide a record of the spectrum of renal diseases in Sri Lanka. Methods Renal biopsies performed at the nephrology unit in Colombo South Teaching Hospital (CSTH), Sri Lanka from March 2018 to October 2019 was retrospectively studied. Indications for renal biopsy were nephrotic range proteinuria, sub nephrotic range proteinuria, acute kidney injury without obvious etiology, chronic renal disease without obvious etiology and haematuria. Results A total of 140 native kidney biopsies were analyzed in which majority were females (55.7%). The mean age of the population was 46 ± 15.3 years. The most common indications for renal biopsy were nephrotic range proteinuria (54.3%), followed by sub-nephrotic range proteinuria (14.3%), nephrotic range proteinuria with haematuria (14.3%), sub-nephrotic range proteinuria with haematuria (9.3%), AKI without known cause (4.3%), and CKD without known cause (3.6%). The leading histopathological diagnoses were FSGS (22.1%), lupus nephritis (20%), PSGN (17.1%), DN (12.1%), HTN (9.3%), MCD (6.4%), IgA nephropathy (5.7%), IN (4.3%), vasculitis (2.1%), and MGN (0.7%). Conclusions The most common indication for renal biopsy was nephrotic range proteinuria in our population. FSGS was the most prevalent histopathological diagnosis and the least frequent diagnosis reported was MGN. The spectrum of renal diseases could differ according to the study location and it changes over time. Therefore, a renal biopsy registry is needed for documenting the changing disease pattern in Sri Lanka.

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Section: Discussionsupporting

confidence: 90%

Clinicopathological spectrum of biopsy-proven renal diseases of patients at a single center in Sri Lanka: a cross sectional retrospective review

et al. 2023

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“…1 b). In South Korea, the mean diagnosis rate was 41% (median: 38.1%; range: 25.8-61.9%) among patients undergoing renal biopsies [ 67 , 69 , 71 , 72 ] and around 51.6% (average of 51.3% and 51.9%) among PGN patients [ 68 , 70 ] (Fig. 1 c).…”

Section: Resultsmentioning

confidence: 99%

“…Sixty-nine publications were included for this review, among which 38 were from mainland China (2015-2021) , 15 from Japan (2003-2021) [49][50][51][52][53][54][55][56][57][58][59][60][61][62][63], 10 from South Korea (2010-2020) [64][65][66][67][68][69][70][71][72][73], 3 from Taiwan (2014-2019) [74][75][76], and 3 from Australia (2001-2021) [77][78][79]; characteristics of the studies are shown in Supplementary Table S2. Approximately 83% the publications reported a retrospective study design (n = 57).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-five publications were identified with diagnosis rates among 2 populations: patients who received renal biopsies and PGN patients [13, 14, 17-19, 21, 22, 24, 30, 31, 33-36, 39, 40, 43-48, 52, 59, 67-72, 74-76, 79]. Twenty-one publications were from mainland China [13, 14, 17-19, 21, 24, 30, 31, 33-36, 39, 40, 43-48], 6 from South Korea [67][68][69][70][71][72], 3 from Taiwan [74][75][76], 3 from Japan [52,55,59], and 1 from Australia [79]. The majority (88%) were cohort studies (n = 17) [13, 21, 31, 33, 35, 36, 39, 40, 43-46, 52, 68-71] and cross-sectional studies (n = 13) [14, 17-19, 21, 24, 34, 37, 47, 59, 67, 72, 74, 79], with the remainder being an annual report [76], a registry study [55] and a chart review [75].…”

Section: Prevalence and Diagnosis Ratementioning

confidence: 99%

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Review on epidemiology, disease burden, and treatment patterns of IgA nephropathy in select APAC countries

Zaidi,

Du,

Tang

et al. 2024

BMC Nephrol

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Background Immunoglobulin type A (IgA) nephropathy is the most common primary glomerulonephritis (GN) worldwide with higher rates in East and Pacific Asia compared to North America and Europe. Despite high reported prevalence of IgAN in these countries, the overall disease prevalence across Asia is not available. Treatment patterns of IgAN patients across Asian countries have also not been summarized. The aim of this study was to review and summarize evidence on IgA nephropathy prevalence, treatment patterns, and humanistic and economic burden in mainland China, Taiwan, South Korea, Japan, and Australia. Methods A targeted literature review was conducted in PubMed and local databases in China (including Taiwan), South Korea, Japan, and Australia between January 2010-December 2021. Website literature searches were conducted using Google Scholar and Baidu. Results Sixty-nine publications and 3 clinical guidelines were included. Incidence ranged from 0 to 10.7 per 100 000 people per year in Australia, Japan, and Taiwan, and ranged from 6.3 to 24.70% among patients who underwent renal biopsy in mainland China. Prevalence and diagnosis rates ranged from 0 to 72.1% in mainland China, South Korea, Taiwan, Japan, and Australia. Mortality rates in mainland China, South Korea, and Japan varied widely. The top 3 commonly used therapies were angiotensin-converting enzyme inhibitor/angiotensin receptor blockers (0.9-99.6%), corticosteroids (3.5-100%), and immunosuppressants (1.6-85.5%) in Japan, mainland China, and South Korea. Patient quality of life was measured by different tools, and annual hospitalization costs ranged from $1 284.73 to $2 252.12 (2015–2018) in China. Conclusions The prevalence of IgA nephropathy among the general population in select countries/regions is not commonly available, despite evidence from studies and clinical guidelines. In addition, it is observed across geographic regions that heterogeneity exists in prevalence rates, and large variations exist in treatment patterns. There is need to fill in these gaps to understand the contributing factors behind the differences through population-based, multi-center, and real-world studies.

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Clinical and Histopathological Analysis of the Kidney Biopsies of 2,450 Patients seen over 30 Years at Chungnam National University Hospital

Cited by 2 publications

References 14 publications

Clinicopathological spectrum of biopsy-proven renal diseases of patients at a single center in Sri Lanka: a cross sectional retrospective review

Clinicopathological spectrum of biopsy-proven renal diseases of patients at a single center in Sri Lanka: a cross sectional retrospective review

Review on epidemiology, disease burden, and treatment patterns of IgA nephropathy in select APAC countries

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