Clinical and histological features of cytomegalovirus hepatitis in previously healthy adults

Kanno, Atsushi; Abe, Masahide; Yamada, Miki; Murakami, Kazuhiro

doi:10.1111/j.1600-0676.1997.tb00794.x

Cited by 37 publications

(18 citation statements)

References 17 publications

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“…With Epstein-Barr virus infection, the hepatitis results in a diffuse lymphocytic sinusoidal infiltrate in a single file "string of beads" pattern with small Kupffer cell clusters and discrete noncaseating granulomas. 71,72 Drugs and chemicals Numerous drugs have been implicated in the development of granulomas in the liver or granulomatous hepatitis. The overall incidence of drug-induced hepatic granulomas is thought to be 10%.…”

Section: Other Viral Infectionsmentioning

confidence: 99%

Granulomatous liver diseases: A review

Coash

Forouhar

et al. 2012

Journal of the Formosan Medical Association

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Granulomas that consist of focal accumulations of macrophages are commonly found in the liver due to stimulation of the immune system by a number of agents. Manifestations are variable depending on whether the underlying cause is a systemic disease or a primary hepatic granulomatous reaction. This article describes the common causes, presentation, histopathology, and manifestations of granulomatous diseases as well as various diagnostic and management strategies.

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Section: Other Viral Infectionsmentioning

confidence: 99%

Granulomatous liver diseases: A review

Coash

Forouhar

et al. 2012

Journal of the Formosan Medical Association

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“…Several authors reported cases of HCMV hepatitis in immunocompetent patients. [7][8][9][10][11][12][13] Mild-moderately elevated levels of transaminases and various histopathological changes of the liver were encountered in these patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human cytomegalovirus co-infection in patients with chronic viral hepatitis B and C: A comparison of clinical and histological aspects

Bayram¹,

Özkur²,

Erkılıç³

2009

Journal of Clinical Virology

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“…Human CMV hepatitis occurs as part of disseminated CMV infection. It occurs mainly among liver or kidney transplant recipients or immunosuppressed persons [8,9], however many cases of CMV hepatitis in immunocompetent hosts have also been reported [10,11] so that mild-moderately elevated levels of transaminases and various histopathological changes of the liver were encountered in these patients. On the other hand, HCV is a major health problem in Egypt [12,13].…”

Section: Introductionmentioning

confidence: 99%

Assessment of human cytomegalovirus co-infection in Egyptian chronic HCV patients

Tabll

Shoman

Ghanem

et al. 2011

Virol J

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Human cytomegalovirus (HCMV) is the most common cause of severe morbidity and mortality in immune- compromised individuals. This study was conducted to determine the incidence of HCMV infection in HCV patients who either spontaneously cleared the virus or progressed to chronic HCV infection. The study included a total of eighty four cases (48 females and 36 males) that were referred to blood banks for blood donation with an age range of 18-64 years (mean age 37.62 ± 10.03 years). Hepatitis C virus RNA and HCMV DNA were detected in sera by RT-nested PCR and nested PCR respectively in all subjects. Immunoglobulin G levels for HCV and HCMV were determined. Besides, IgM antibodies for HCMV infection were also determined in subjects' sera. Fifty three out of 84 cases (63%) were positive for HCV-RNA while 31 (37%) cases had negative HCV RNA. Forty six (87%) and 13 (25%) cases out of 53 HCV RNA positive patients were positive for HCMV IgG and IgM antibodies respectively. While 20 of 53 cases (38%) had detectable HCMV DNA. To examine the role of HCMV infection in HCV spontaneous resolution, two groups of HCV patients, group 1) chronic HCV infection (positive HCV RNA and positive IgG antibodies) vs group 2) spontaneous resolution (negative HCV RNA and positive IgG antibodies) were compared. The percentages of positive CMV IgG and IgM results is higher in chronic HCV patient than those in spontaneously cleared HCV patients and the difference is highly statistically significant (P value < 0.001). Also, there is a general trend towards elevated levels of CMV IgG antibodies in HCV chronic patients than those in spontaneously cleared HCV patients (P value < 0.02). HCMV DNA detection in group 1 was more than twice the value observed in group 2 (38% vs 14.3%, P value < 0.001). Moreover, levels of liver enzymes were significantly higher in HCV RNA positive cases co-infected with HCMV DNA than HCMV negative cases (P value < 0.001). The results indicate the role of HCMV in the liver pathogenesis. We conclude that chronic HCV patients co-infected with HCMV infection can be regarded as high risk groups for liver disease progression where they should be monitored for the long term outcome of the disease.

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Clinical and histological features of cytomegalovirus hepatitis in previously healthy adults

Cited by 37 publications

References 17 publications

Granulomatous liver diseases: A review

Granulomatous liver diseases: A review

Prevalence of human cytomegalovirus co-infection in patients with chronic viral hepatitis B and C: A comparison of clinical and histological aspects

Assessment of human cytomegalovirus co-infection in Egyptian chronic HCV patients

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