Clinical and Histological Effects of Glycolic Acid at Different Concentrations and pH Levels

DiNardo, Joseph C; Grove, Gary L.; Moy, Lawrence S.

doi:10.1111/j.1524-4725.1996.tb00341.x

Cited by 42 publications

(41 citation statements)

References 4 publications

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“…29,30) Additionally, glycolic acid can provide a protective anti-oxidative effect on photodamaged skin, 31) increase the hyaluronic acid level, and increase the number and quality of elastic fiber tissues. [32][33][34] Therefore, 10H2DA may exert its pharmacological activities through a mechanism similar to that of glycolic acid.…”

Section: Discussionmentioning

confidence: 99%

Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism

Koya‐Miyata

Okamoto

Ushio

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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We have previously shown that royal jelly (RJ) promoted collagen production by skin fibroblasts in the presence of ascorbic acid-2-O-alpha-glucoside (AA-2G). In this study, we purified the honeybee RJ-derived collagen production-promoting factor (HBRJ-CPF) from an alkali-solubilized fraction of RJ by C18 reverse-phase column chromatography. The elution profile by the C18 column chromatography and the molecular mass of the purified HBRJ-CPF material coincided with those of 10-hydroxy-2-decenoic acid (10H2DA). We then examined the collagen productionpromoting activities of several commercially available fatty acids contained in RJ. We found that 10H2DA and 10-hydroxydecanoic acid increased the collagen production in a dose-dependent manner. Furthermore, 10H2DA induced the fibroblast cell line, NHDF, to produce transforming growth factor-1 (TGF-1) which is an important factor for collagen production. As expected, the collagen production-promoting activity of 10H2DA was neutralized by the anti-TGF-1 antibody. These result suggest that HBRJ-CPF identified as 10H2DA promoted the collagen production of AA-2G-treated fibroblasts by inducing TGF-1 production.

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Section: Discussionmentioning

confidence: 99%

Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism

Koya‐Miyata

Okamoto

Ushio

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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“…The mechanism of action of cr acids on epidermal and dermal compartments needs clarification. Alpha-glycolic acid has been demonstrated effective as a chemical peeling agent (16,17), induces turnover of the stratum corneum (18) and causes a significant increase in glucosaminoglycan and collagen content of epidermis (19). Antioxidant activity ofc~-glycolic acid was also put forward (20).…”

Section: Mal96@mboxunipaitmentioning

confidence: 99%

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Morreale

Livrea

1997

IUBMB Life

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Summary. Considerable interest has been raised concerning the use of natural compounds in preventing skin aging and photoaging In the idea that the combined action of agents increasing epiderlnal turnover with antioxidants could be ach,antageous in cosmetic and therapeuthic treatments, we first investigated if ~z-glycolic acid affected or prevented the antioxidant activity of vitanffn E and of melatonin, two compounds found beneficial as topical photoprotectant. Assays were carried out m vitro either in a biomimetic liposomal system, or in human skin homogenates. Lipid peroxidation was monitored spectrophotometrically by the time course of lipid hydroperoxide production in liposomes and by formation of TBA reactive substances (TBARS) in skin homogenates. Glycolic acid. at 25 ~tM to 1 raM, showed a mild, concentration-dependent antioxidant effect in liposomes, as evalnated by a slight decrease of the peroxidation rate, while, at I mM, reduced TBARS production in skin homogenates by 14 %. Combinations of either vitamin E or melatonin with giycolic acid, in a 1:5 to 1:200 molar ratio, resulted in a clear synergistic protection of liposomes, more evident for the combination of glycolic acid with vitamin E An amount of ~'nergism up to 250% and up to 80% was evahmted with vitamin E and melatonin, respectively. Consumption rate ofvitanffn E during peroxidation of liposomes, in the absence or in the presence of glycolic acid, suggests that regeneration of vitamin E 1nay in part explain the observed synergism. Synergistic antioxidant activity between vitamin E and giycolic acid was also observed in skin homogenates, whereas the effect of glycolic acid on the antioxidunt activity of melatonin appeared additive. However, the combination of these three compounds inhibited TBARS production almost completely.Our data provide evidence that glycolic acid can strongly potentiate the antioxidant action of melatonin and vitamin E. Tiffs may suggest the advantage of combining ~-glycolic acid with these antioxidants in skin designed preparations, both to improve penetration and availability of antioxidants to epidermal layers and to enhance their protective potential.

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“…It is used to reduce wrinkles and to treat acne in many patients around the world. Multiple studies have focused on optimization of the application of glycolic acid [1][2][3]. Current studies are evaluating the inhibitory effect of glycolic acid on UV induced skin tumor development [4].…”

Section: Introductionmentioning

confidence: 99%

Collision induced dissociation of deprotonated glycolic acid

Baker

Gabryelski

2007

International Journal of Mass Spectrometry

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Clinical and Histological Effects of Glycolic Acid at Different Concentrations and pH Levels

Abstract: All pH levels and concentrations demonstrated significant improvement in the condition of the skin with trends implying that increasing the pH increases efficacy.

Cited by 42 publications

References 4 publications

Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism

Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism

Synergistic effect of glycolic acid on the antioxidant activity of α‐tocopherol and melatonin in lipid bilayers and in human skin homogenates

Collision induced dissociation of deprotonated glycolic acid

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