Clinical and Histologic Evaluation of Ingenol Mebutate 0.015% Gel for the Cosmetic Improvement of Photoaged Skin

Abstract

Topical ingenol mebutate 0.015% gel produces cosmetic improvement of photoaged skin within 60 days of application.

Patient-centered management of actinic keratosis. Results of a multi-center clinical consensus analyzing non-melanoma skin cancer patient profiles and field-treatment strategies

“…[12,16] For many cases of AK, several treatment approaches are potentially suitable based on existing guidelines. This document therefore further complements existing guidelines and previous consensus papers by providing recommendations about selecting the appropriate Ingenol mebutate was one of the treatment options proposed for many of the profiles and this was driven by its association with good cosmetic outcomes [17,18] ; the predictable nature of the treatment and related short-term local skin reactions [19][20][21][22] ; and the fact that the administration regimen of ingenol mebutate allows for flexible use, as patients are able to decide how and when it is used according to their needs and individual condition. In a randomized, evaluator-blinded trial of ingenol mebutate 0.015% gel and diclofenac sodium 3% gel, patients experienced a shorter duration of skin reactions, with a peak after one week, with ingenol mebutate compared with diclofenac sodium, who experienced reactions throughout the 90-day treatment.…”

Anti-aging effects of ingenol mebutate for patients with actinic keratosis

“…1 Recently, there have been reports of improvements in skin elasticity, wrinkles, and mottled pigmentation after the application of IM gel in patients with multiple AK lesions. 2,3 In this study, we aimed to investigate histologic and molecular alterations after field cancerization by using topical IM gel in patients with multiple AK lesions and elucidate the mechanism underlying the skinrejuvenating effect of IM gel.…”