Clinical and experimental evidence for a gastric fundic hormone affecting glucose absorption

Elder, J. B.; Barmada, Suzanne; Burdett, Keith; Pigeon, Janet; Jackson, Katherine; Warwick, F.

doi:10.1016/0167-0115(80)90082-8

Cited by 2 publications

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“…The effect on antral absorption was transferable by injection of portal serum taken during the experiment, into a second rabbit.3 Further strong evidence for a fundic humoral mechanism affecting 99mTc and glucose absorption was obtained in experiments on conscious dogs with antral pouches containing tracer substances and autotransplanted gastric fundic pouches exposed to alkaline buffer pH 8.2 Preliminary evidence has been reported for this phenomenon in man. 7 A rat model was devised to observe absorption of tracer substances from jejunum and antrum. This model exhibited reduced jejunal absorption of tracers after fundic distension or alkalinisation.…”

Section: Discussionmentioning

confidence: 99%

Effects of porcine gastric fundic factor, somatostatin, substance P, glucagon, neurotensin, bombesin, VIP, motilin, and pentagastrin on jejunal glucose absorption in the rat.

Andrews¹,

Rinno-Barmada²,

Burdett³

et al. 1983

Gut

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SUMMARY The effects of a porcine gastric fundic mucosal extract (molecular weight <10 000) has been compared with the effects of eight candidate gastrointestinal peptides on glucose absorption from the jejunum in a rat model. Bolus injection of the extract produced immediate and marked depression of glucose absorption. None of the candidate peptides tested produced this response, although somatostatin and substance P depressed absorption as a late phenomenon after 30 minutes. We conclude that the effects of the fundic extract are not reproduced by any of these candidate peptides. This strengthens the evidence for a novel gastrointestinal peptide, resident in fundic mucosa, which affects absorption from upper small bowel.There is evidence for a peptide factor, secreted from gastric fundic mucosa, which affects jejunal mucosal absorption. 1-4 Stimulation of gastric fundic mucosa by distension or raised pH significantly reduced luminal loss of glucose, 14C-labelled 3-0-methyl glucose and tracer ions 22Na and 99mTc, from the jejunum. An extract of porcine gastric mucosa also reduced jejunal absorption when infused intravenously in a rat model.4Samples of the porcine gastric fundic mucosal extract contained only small and variable amounts of some of the known gastrointestinal peptides (Bloom, personal communication; Table 1). The present series of experiments was designed to see if the effects of the fundic extract on jejunal absorption could be because of the action of a specific candidate gastrointestinal peptide.

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Section: Discussionmentioning

confidence: 99%

Effects of porcine gastric fundic factor, somatostatin, substance P, glucagon, neurotensin, bombesin, VIP, motilin, and pentagastrin on jejunal glucose absorption in the rat.

Andrews¹,

Rinno-Barmada²,

Burdett³

et al. 1983

Gut

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Gastric fundic inhibition of sugar transport across the intestinal mucosa of guinea-pig

Burdett

Lauterbach

1994

Pfl�gers Arch.

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A low molecular weight peptide designated gastric fundic factor (GFF), extracted from porcine fundic mucosa and administered to the serosal surface of mucosal sheets from guinea-pig intestine, decreased the transport of luminal glucose across the sheets by up to 70%. The results show that gastric fundic inhibition of glucose absorption observed in different animal models in vivo can be reproduced in vitro, and suggest that the intestinal mucosa itself is the target for peptide hormone(s) released by the gastric fundic mucosa. Simultaneous transport of alpha-aminoisobutyric acid, a nonmetabolisable amino acid, through the jejunal mucosa was unaffected as was paracellular permeation by inulin. However, amino acid transport was also reduced when GFF was administered to sheets of ileal mucosa. The intestinal mucosal sheet in vitro is a sensitive and convenient model with which to follow the purification of GFF to homogeneity.

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Clinical and experimental evidence for a gastric fundic hormone affecting glucose absorption

Cited by 2 publications

References 0 publications

Effects of porcine gastric fundic factor, somatostatin, substance P, glucagon, neurotensin, bombesin, VIP, motilin, and pentagastrin on jejunal glucose absorption in the rat.

Effects of porcine gastric fundic factor, somatostatin, substance P, glucagon, neurotensin, bombesin, VIP, motilin, and pentagastrin on jejunal glucose absorption in the rat.

Gastric fundic inhibition of sugar transport across the intestinal mucosa of guinea-pig

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