Gastric fundic inhibition of sugar transport across the intestinal mucosa of guinea-pig

Burdett, Keith; Lauterbach, F.

doi:10.1007/bf00378526

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…The physiological significance of these transporters is distinct, because the uptake of dietary carbohydrate is mostly dependent on them. The activity of glucose transporters is known to be regulated by such internal factors as hormones and cytokines [25], but recent studies suggest that glucose transport is also affected by food factors.…”

Section: Intestinal Transporters and Their Propertiesmentioning

confidence: 99%

Modulation of intestinal functions by food substances

Shimizu¹

1999

Nahrung

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The small intestinal epithelium plays a crucial role in the digestion/modification of food components, absorption of nutrients and recognition of food-derived signals. It also acts as a barrier against unfavourable materials in food. These intestinal functions may be influenced by food substances. In this paper, the effects of various food substances on the intestinal functions, particularly the absorption functions, are discussed. A new assay method, using a monolayer culture system of human intestinal epithelial cells, is applied to examine food-derived substances which could modulate the tight junction (TJ). Capsianoside, a diterpene glycoside from sweet pepper, was isolated and identified as one of the TJ-modulating substances. Those substances can be expected to facilitate the paracellular absorption of small molecular functional substances such as bioactive oligopeptides. The use of a human intestinal cell culture system also enabled us to make a simple screen test for food substances which affect the intestinal transporter functions. Substances which could suppress the activity of intestinal glucose transporters, for example, can be expected to reduce the dietary glucose uptake in the intestinal epithelium and control the blood glucose level. Polyphenolic compounds from plants, including green tea, were found to have such activity. Modulation of the brush border enzymes by food substances is also discussed.

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Section: Intestinal Transporters and Their Propertiesmentioning

confidence: 99%

Modulation of intestinal functions by food substances

Shimizu¹

1999

Nahrung

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“…Using a model with biological lipid membranes, the same combination leads to an enrichment of Cp in the mucous membrane on the one hand and to permeation into the acceptor on the other. The influence of absorption enhancers on the active D-glucose transport was examined in biological lipid membranes (Brot et al 1986;Burdett & Lauterbach 1994). The results show that the concentration profile of the glucose in the acceptor corresponds to that concentration given in the literature (Kakemi et al 1969;Grass & Sweetana 1998).…”

Section: Discussionmentioning

confidence: 96%

In-vitro and in-vivo studies of cefpirom using bile salts as absorption enhancers

Mrestani

Bretschneider

Härtl

et al. 2003

Journal of Pharmacy and Pharmacology

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Cephalosporins have to be administered by injection because of the poor intestinal absorption of the orally delivered drugs. Because of the obvious drawbacks of drug delivery by injection, the development of alternatives with enhanced oral bioavailability is receiving much attention in pharmaceutical research. Cefpirom (Cp) is a new semi-synthetic amino-2-thiazolyl-methoxyimino cephalosporin that has been substituted in position 3 with a cyclopenteno-pyridinium group in order to create a zwitterionic compound. It exhibits highly hydrophilic properties, as shown from its extremely low partition coefficient, and therefore its lipophilicity was increased using bile salts. The effect of this on the partition coefficients determined in the n-octanol/buffer system was confirmed using an in-vitro transport model with artificial and biological membranes. The pharmacokinetic properties of Cp were investigated in rabbits after intraduodenal administration with and without bile salts. Furthermore, the physiological compatibility of the bile salts was investigated using active D-glucose transport.

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Gastric fundic inhibition of sugar transport across the intestinal mucosa of guinea-pig

Cited by 2 publications

References 12 publications

Modulation of intestinal functions by food substances

Modulation of intestinal functions by food substances

In-vitro and in-vivo studies of cefpirom using bile salts as absorption enhancers

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