Clinical and epidemiological profile of cerebral venous thrombosis

Abstract

A retrospective record-based cohort design was conducted including all patients admitted with diagnosis of CVT in 2 main tertiary hospitals in Aseer Region between 2015 to the end of 2018. The study hospitals were Aseer Central Hospital and Armed Forces Original ArticleHospitals Southern Region. The data were collected by structured data sheets, including sociodemographic data. Assessment of known risk factors for CVT, clinical presentation, treatment received, and clinical outcome after treatment were extracted. Results:The study included 119 patients with CVT, whose ages ranged from 15 to 97 years, with a mean age of 35.5-+14.1 years. Majority of the patients were females )81.5%(. Headache was the most presenting )82.4%( symptom, followed by vomiting )30.3%( and a decreased level of consciousness. Thirty-three cases )27.7%( had complications, and recanalization was recorded among 92 cases )94.8%( based on follow up vascular imaging. Conclusion:The study revealed that most of the cases of CVT had favorable clinical outcome and recanalization, especially those who had a shorter duration untildiagnosis. Young females were the most affected group.

Derivation of a clinical decision rule to exclude cerebral venous sinus thrombosis in emergency department patients: A retrospective cohort study

“…The clinical features tested in the present study were chosen from the literature 2,3,8–11 . For most features, we found similar associations; however, there were several exceptions with no association found for new/different headaches, headaches worse on lying down and blurred vision.…”

“…Clinical features associated with CVST considered for inclusion in the rule were determined by literature review. 2,3,[8][9][10][11] The reference standard was all of the following: CTV or MRV 2,12 with a consultant radiologist report stating CVST was present; the treating neurologist considered the diagnosis to be CVST as reflected by the discharge summary; the patient received treatment with an anticoagulant (where no anticoagulation was given there must be an explanation in the discharge summary explaining why).…”

“…Clinical features associated with CVST considered for inclusion in the rule were determined by literature review 2,3,8–11 . These were age, vomiting, thunderclap headache, worsening of the headache in the morning or with lying down, new/different headache, complaint of blurred vision, altered consciousness (GCS <14), focal neurologic deficit, papilloedema, seizure and confusion.…”

“…1 CVST may present with headaches, stroke-like syndromes, seizures or a syndrome of raised intracranial pressure, while 10% do not present with headache. 2,3 Although CVST is uncommon, this varied clinical spectrum means it is in the differential diagnosis for many ED presentations.…”

“…Cerebral venous sinus thrombosis (CVST) is an uncommon disease having a prevalence of 0.4% of ED patients with non‐traumatic headache 1 . CVST may present with headaches, stroke‐like syndromes, seizures or a syndrome of raised intracranial pressure, while 10% do not present with headache 2,3 . Although CVST is uncommon, this varied clinical spectrum means it is in the differential diagnosis for many ED presentations.…”