Clinical and epidemiologic profile of lower respiratory tract infections associated with human bocavirus

Leon, Cristiano do Amaral de; Amantéa, Sérgio L.; Pilger, Diogo André; Cantarelli, Vlademir Vicente

doi:10.1002/ppul.22732

Cited by 21 publications

(22 citation statements)

References 43 publications

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“…Both of the models showed that the prevalence of HBoV1 was significantly correlated with temperature and relative humidity ( Table 2). In detail, HBoV1 prevalence was positively correlated with temperature, that is consistent with previous reports [47,49]. Conversely, HBoV1 prevalence was negatively correlated with relative humidity, this was different from a previous report in Suzhou [47], which may be related to Guangzhou high humidity (mean monthly relative humidity was 77.2 ± 7.3%) ( Fig.…”

Section: Discussionsupporting

confidence: 76%

Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region

Liu

Chen

et al. 2018

BMC Infect Dis

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BackgroundHuman bocavirus 1 (HBoV1) is an important cause of acute respiratory illness (ARI), yet the epidemiology and effect of meteorological conditions on infection is not fully understood. To investigate the distribution of HBoV1 and determine the effect of meteorological conditions, hospitalized pediatric patients were studied in a subtropical region of China.MethodsSamples from 11,399 hospitalized pediatric patients (≤14 years old), with ARI were tested for HBoV1 and other common respiratory pathogens using real-time PCR, between July 2009 and June 2016. In addition, local meteorological data were collected.ResultsOf the 11,399 patients tested, 5606 (49.2%) were positive for at least one respiratory pathogen. Two hundred forty-eight of 11,399 (2.2%) were positive for HBoV1 infection. Co-infection was common in HBoV1-positive patients (45.2%, 112/248). A significant difference in the prevalence of HBoV1 was found in patients in different age groups (p < 0.001), and the peak prevalence was found in patients aged 7–12 months (4.7%, 56/1203). Two HBoV1 prevalence peaks were found in summer (between June and September) and winter (between November and December). The prevalence of HBoV1 was significantly positively correlated with mean temperature and negatively correlated with mean relative humidity, and the mean temperature in the preceding month had better explanatory power than the current monthly temperature.ConclusionsThis study provides a better understanding of the characteristics of HBoV1 infection in children in subtropical regions. Data from this study provide useful information for the future control and prevention of HBoV1 infections.

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Section: Discussionsupporting

confidence: 76%

Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region

Liu

Chen

et al. 2018

BMC Infect Dis

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“…One might argue that HBoV is only an aggravating factor of respiratory disease, a persisting virus that is reactivated by the inflammatory process or an innocent bystander that is just detected by chance [32]. Many studies have confirmed the association between HBoV infections in hospitalized children and wheezing episodes [33][34][35], while other studies fail to find an obvious relationship between HBoV infection and distinct clinical manifestations [24]. In our monoinfected group, three infants were born at a gestational age of 25-28 weeks and already had weak lungs and an immature immune system as a result of their premature birth.…”

Section: Discussionmentioning

confidence: 99%

“…This child showed persistent HBoV PCR positivity in seven separate determinations (6 in monoinfection, 1 in coinfection). The other three premature infants expressed HBoV at higher Cq values (30)(31)(32)(33)(34) and had only mild deterioration of their respiratory condition. A child born at a gestational age of 26 weeks had severe BPD with a need for invasive ventilation (conventional and high-frequency oscillation) for 33 days followed by 18 days of CPAP.…”

Section: Nosocomial Monoinfectionmentioning

confidence: 93%

Human bocavirus infection in Belgian children with respiratory tract disease

et al. 2019

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Human bocavirus (HBoV) has been detected primarily in children with acute lower respiratory tract disease (LRTD), but its occurrence, clinical profile, and role as a causative agent of RTD are not clear. The aim of this study was to investigate the prevalence and the potential clinical relevance of HBoV. Using molecular tests, we tested 1352 nasopharyngeal samples obtained between October 1, 2017 and April 30, 2018 from children up to the age of 16 with RTD for the presence of HBoV DNA and 20 other respiratory pathogens at three different hospitals in Belgium. HBoV was detected in 77 children with a median age of 10.6 months. Consecutive samples were available for 15 HBoV-positive children and showed persistent HBoV positivity in four of them. Monoinfection was observed in six infants. Four of them were born prematurely and were infected during hospitalization at the neonatal intensive care unit (NICU). Only one of these six monoinfected children was diagnosed with recurrent wheezing due to HBoV. This child was carried to term and had a high viral load. Coinfections, most frequently with rhinovirus (52.1%) and adenovirus (49.3%), were observed in 72 patients. In seventeen of them in which HBoV was present at high viral load or higher viral load than its copathogens, bronchi(oli)tis (n = 8), recurrent wheezing (n = 8) or episodic wheezing (n = 1) were diagnosed. Our results suggest that HBoV infection at high viral load in infants is associated with wheezing (P = 0.013, Cramer's V = 0.613). Abbreviations BPDBronchopulmonary dysplasia CLD Chronic lung disease CPAP Continuous positive airway pressure Cq Quantitation cycle CRP C-reactive protein EV Enterovirus GI Gastrointestinal HAdV

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“…4,6 In Brazil, RSV is the most common viral pathogen found in episodes of LRTI; other frequent viruses include influenza, rhinovirus, parainfluenza, adenovirus, metapneumovirus, and bocavirus. [7][8][9][10][11][12][13][14][15][16] Some studies conducted in Brazil have suggested a clear seasonal pattern for RSV infections, with predominance from March to July, and a smaller number of cases in the summer months, especially November to February. [14][15][16][17][18][19] Other viruses have been investigated to a lesser extent, but a seasonal pattern was found for different respiratory viruses in Southern and Southeastern Brazil, where the winter is cold and dry.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16][17][18][19] Other viruses have been investigated to a lesser extent, but a seasonal pattern was found for different respiratory viruses in Southern and Southeastern Brazil, where the winter is cold and dry. 10,13,20 Only a few studies were conducted to investigate the prevalence and seasonal patterns of different viral infections among children with an episode of LRTI seen at hospitals from Northeastern Brazil, where the winter is warm and wet. 14,16,[21][22][23][24] Such studies were typically conducted in only 1 major city in the region and have not allowed for concurrent assessments within different areas of the Northeastern region of Brazil.…”

Section: Introductionmentioning

confidence: 99%

Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil

et al. 2016

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Few studies, each limited to a single major city, have investigated the prevalence and seasonal patterns of different viruses among children with low respiratory tract infections (LRTI) in Northeastern Brazil. The aim of this study was to determine the frequency of respiratory syncytial virus (RSV) and of 7 other viruses in children for LRTI in 4 capitals from this region, and investigate their association with several risk factors, including meteorological data.From April 2012 to March 2013, 507 children, aged up to 24 months and hospitalized with LRTI in one of the participating centers at Aracajú, Salvador, Recife, and Maceió, had a sample of nasopharyngeal aspirate collected and analyzed for the following viruses by reverse-transcription polymerase chain reaction followed by hybridization on low-density microarrays: RSV, influenza, parainfluenza, adenovirus, rhinovirus, metapneumovirus, bocavirus, and coronavirus.The result was positive in 66.5% of cases, RSV was the most common virus (40.2%). Except for rhinovirus (17%), all other virus had frequency rates lower than 6%. Viral coinfections were detected in 13.8% of samples. Possible related risk factors for RSV infection were low age upon entry, attendance of daycare, low gestational age, and low educational level of the father. The relative frequency of viral infections was associated with increasing temperature and decreasing humidity separately, but the results also suggested both associated with increased frequency of RSV. Some of these findings differ from those reported for other regions in Brazil and may be used to guide policies that address LRTI.

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Clinical and epidemiologic profile of lower respiratory tract infections associated with human bocavirus

Abstract: We conclude that HBoV detection in infants with AVB and recurrent wheezing of viral etiology in Brazil is similar to that reported in other countries. The clinical course of HBoV detection is no different from that of other respiratory viruses commonly found in this age range.

Cited by 21 publications

References 43 publications

Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region

Epidemiology of HBoV1 infection and relationship with meteorological conditions in hospitalized pediatric patients with acute respiratory illness: a 7-year study in a subtropical region

Human bocavirus infection in Belgian children with respiratory tract disease

Relative frequency, Possible Risk Factors, Viral Codetection Rates, and Seasonality of Respiratory Syncytial Virus Among Children With Lower Respiratory Tract Infection in Northeastern Brazil

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