Human bocavirus infection in Belgian children with respiratory tract disease

Verbeke, Vanessa; Floré, Katelijne; Vandewal, Wouter; Debulpaep, Sara; Sauer, Kate; Cardoen, Frederik; Padalko, Elizaveta

doi:10.1007/s00705-019-04396-6

Cited by 20 publications

(16 citation statements)

References 36 publications

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“…Furthermore, HBoV was detected in 1.9% of the patients in Kuwait, with a peak incidence among children <1 year of age, as well as the predominance of HBoV-1 genotype ( 101 ). In a Belgian study, HBoV was detected in 5.7% of children with a median age of 10.6 months ( 102 ).…”

Section: An Overview and Global Trendsmentioning

confidence: 99%

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Ljubin‐Sternak

Meštrović

Lukšić

et al. 2021

Front. Public Health

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Respiratory viral infections are the leading cause of morbidity and mortality in the world; however, there are several groups of viruses that are insufficiently routinely sought for, and can thus be considered neglected from a diagnostic and clinical standpoint. Timely detection of seasonality of certain respiratory viruses (e.g., enveloped viruses such as seasonal coronaviruses) in the local context can aid substantially in targeted and cost-effective utilization of viral diagnostic approaches. For the other, non-enveloped and year-round viruses (i.e., rhinovirus, adenovirus, and bocavirus), a continuous virological diagnosis needs to be implemented in clinical laboratories to more effectively address the aetiology of respiratory infections, and assess the overall impact of these viruses on disease burden. While the coronavirus disease 2019 (COVID-19) pandemic is still actively unfolding, we aimed to emphasize the persistent role of seasonal coronaviruses, rhinoviruses, adenoviruses and bocaviruses in the aetiology of respiratory infections. Consequently, this paper concentrates on the burden and epidemiological trends of aforementioned viral groups on a global level, but also provides a snapshot of their prevalence patterns in Croatia in order to underscore the potential implications of viral seasonality. An overall global prevalence in respiratory tract infections was found to be between 0.5 and 18.4% for seasonal coronaviruses, between 13 and 59% for rhinoviruses, between 1 and 36% for human adenoviruses, and between 1 and 56.8% for human bocaviruses. A Croatian dataset on patients with respiratory tract infection and younger than 18 years of age has revealed a fairly high prevalence of rhinoviruses (33.4%), with much lower prevalence of adenoviruses (15.6%), seasonal coronaviruses (7.1%), and bocaviruses (5.3%). These insights represent a relevant discussion point in the context of the COVID-19 pandemic where the testing of non-SARS-CoV-2 viruses has been limited in many settings, making the monitoring of disease burden associated with other respiratory viruses rather difficult.

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Section: An Overview and Global Trendsmentioning

confidence: 99%

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Ljubin‐Sternak

Meštrović

Lukšić

et al. 2021

Front. Public Health

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“…Bocaparvoviruses in the genus Bocaparvovirus frequently infect young animals and humans through the fecal–oral tract, causing respiratory (Priestnall et al 2014 ; Verbeke et al 2019 ) and gastrointestinal symptoms (Bodewes et al 2014 ; Lin et al 2020 ), and have a broad host spectrum that infect animals such as cows, pigs, rats, cats, and dogs (Qiu et al 2007 ; Bodewes et al 2014 ; Lau et al 2017 ; Pfankuche et al 2016 ; Piewbang et al 2019 ). According to the latest report of the International Committee on Taxonomy of Viruses (ICTV), the genus Bocaparvovirus is divided into 25 species, most of which are novel bocavirus: Carnivore bocaparvovirus 1–6, Chiropteran bocaparvovirus 1–4, Lagomorph bocaparvovirus 1, Pinniped bocaparvovirus 1–2, Primate bocaparvovirus 1–2, Rodent bocaparvovirus 1–2, and Ungulate bocaparvovirus 1–8.…”

Section: Introductionmentioning

confidence: 99%

First detection of feline bocaparvovirus 2 and feline chaphamaparvovirus in healthy cats in Turkey

Hasan

Can-Şahna

2021

Vet Res Commun

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The pet cat’s population and the number of viruses that infect them are increasing worldwide. Recently, feline chaphamaparvovirus (FeChPV, also called fechavirus) and feline bocaparvovirus (FBoV) infections, which are novel parvovirus species, have been reported in cats from different geographic regions. Here, we investigated FBoV 1–3 and FeChPVs in healthy cats in Turkey using PCR, where nuclear phosphoprotein 1 (NP1) is targeted for FBoV and NP for FeChPV. For this purpose, oropharygeal swabs were obtained from 70 healthy cats with different housing status from June 15 to December 1, 2020. After PCR screening tests, six out of 70 cats (5/47 shelter cats; 1/23 domestic cats) were found to be positive for FBOV, while two were positive for FeChPV (1/47 shelter cats; 1/23 domestic cats). No cat was found in which both viruses were detected. The nucleotide (nt) sequence comparison in the 310 base pair (bp) NP gene of the two FeChPVs identified in this study shared a high identity with each other (95.0% nt and 99% aa identities) and with previously reported FeChPVs (92.4–97.1% nt and 98.1–99.0% aa identities), including 313R/2019/ITA, 49E/2019/ITA, VRI_849, 284R/2019/ITA, and IDEXX-1. Here, the near-full length (1489 nt, 495 amino acids-aa) of the VP2 gene of the FechaV/Tur-2020/68 isolate obtained from the study was also sequenced. The nt and aa identity ratio of this isolate with other FeChPVs was 98.0–98.5%-96–96.5%, respectively. Sequences of the 465 bp NP1 gene of the six Turkish FBoV strains shared high identities with each other (99.6–100% nt and 99.3–100% aa identities) and with those of FBoV-2 strains (97.8–99.1% nt and 98.0–100% aa identities), including 16SY0701, 17CC0505-BoV2, HFXA-6, and POR1. All FBoVs detected in this study were classified as genotype 2, similar to the study conducted in Japan and Portugal. Here, the NS1 (partial), NP1, VP1 and VP2 gene of the FBoV-2/TUR/2020–14 strain obtained from the study were also sequenced and the nt and aa sequences showed high identities to the above-mentioned FBoV-2 strain/isolates (> 96%, except for the aa ratio of strain 16SY0701). In conclusion, this study shows that FBoV and FeChPV are present in healthy cats in Turkey, and these viruses can be detected from oropharyngeal swabs. Our findings contribute to further investigation of the prevalence, genotype distribution, and genetic diversity of Turkish FBoVs and FeChPVs, adding to the molecular epidemiology of FBoV and FeChPVs worldwide.

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“…This may be related to the small size of the SARS-CoV-2 PCR-positive group and the long shedding period after a previous bocavirus infection. 33 The SARS-CoV-2 PCR-negative group, 94% of whom were symptomatic, included only six patients with RSV infection and four patients with influenza-parainfluenza infection. All around the world, it became evident along the course of the COVID-19 pandemic that other viral respiratory infections significantly diminished, probably due to a combination of factors.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Tract Pathogens in the COVID-19 Era: Data from a Pediatric Emergency Department

Yildiz

Ünal

Aydın

et al. 2021

J Pediatr Infect Dis

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Objective The frequency of coinfections in pediatric Coronavirus disease 2019 (COVID-19) cases and their impact on the clinical course are not fully understood. We aimed to investigate the viral and bacterial respiratory pathogens in children admitted to the pediatric emergency department (PED), their clinical course, and the presence of coinfections during the early months of the COVID-19 pandemic. Methods Clinical, laboratory and radiological findings, viral and bacterial pathogens detected by multiplex polymerase chain reaction (PCR) tests in nasopharyngeal swabs, clinical course, and treatments of all children who were tested for severe acute respiratory coronavirus 2 (SARS-CoV-2) at the PED between March 16 and May 15, 2020, were recorded. SARS-CoV-2 PCR-positive and negative groups were compared. Results Out of 570 patients tested for SARS-CoV-2 during the study period, 43 were found positive (7.5%). Non-SARS-CoV-2 viral pathogens were more common in the SARS-CoV-2 PCR-negative group than the SARS-CoV-2 PCR-positive group (13.2%, n = 68 versus 4.7%, n = 2), but this result was not statistically significant. Leukocyte, neutrophil, lymphocyte, and platelet counts were lower in SARS-CoV-2 PCR-positive group. Bacterial panel positivity was significantly higher in the SARS-CoV-2 PCR-positive group compared with the SARS-CoV-2 PCR-negative group (52%, n = 12 versus 28%, n = 91; p < 0.05). The presence of coinfection did not alter the course of therapy in SARS-CoV-2 PCR-positive cases. Conclusion While viral coinfections were rare, bacterial panel positivity was common in children with COVID-19, but this had not influenced management decisions. The limitations of the tests should be kept in mind while interpreting the results.

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Human bocavirus infection in Belgian children with respiratory tract disease

Cited by 20 publications

References 36 publications

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

First detection of feline bocaparvovirus 2 and feline chaphamaparvovirus in healthy cats in Turkey

Respiratory Tract Pathogens in the COVID-19 Era: Data from a Pediatric Emergency Department

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