Clinical and Endoscopic Outcomes in COVID-19 Patients With Gastrointestinal Bleeding

Ashktorab, Hassan; Russo, T.; Oskrochi, Gholamreza; Latella, Giovanni; Massironi, Sara; Luca, Martina De; Chirumamilla, Lakshmi G.; Laiyemo, Adeyinka O.; Brim, Hassan

doi:10.1016/j.gastha.2022.02.021

Cited by 12 publications

(8 citation statements)

References 39 publications

(48 reference statements)

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“…They are usually seen as muscle enlargement with increased densities, blood-fluid level and possibly extravasation of contrast. When it comes to the GI tract, upper GI is the most common site of bleeding followed by the lower GI [ 53 , 54 ].…”

Section: Methodsmentioning

confidence: 99%

Gastrointestinal Imaging Findings in the Era of COVID-19: A Pictorial Review

Mavropoulou,

Psoma,

Papachristodoulou

et al. 2023

Medicina

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The potentially fatal COVID-19 pandemic has been associated with a largespectrum of clinical presentations. Beyond the classical pulmonary manifestations, gastrointestinal tract-related symptoms suchas nausea, diarrhea, abdominal distention and pain have been observed in patients, as a consequence of the binding of SARS-CoV-19 to Angiotensin-converting Enzyme 2 (ACE2) receptors in the gastrointestinal (GI) tract. The early recognition ofspecific imaging features, including hepatobiliary involvement, pancreatic involvement, development of solid organ infarcts, ischemic bowel changes and vascular occlusion, plays a key role through the course of the disease. Also, suspicious symptoms, especially in critically ill patients with clinical and biochemical markers of hypovolemia, necessitate timely imaging for bleeding complications. The aim of this pictorial review is to illustrate the spectrum of the GIimaging findings in patients with COVID-19. Awareness of diagnostic imaging hallmarks is crucial to optimize the management of these patients.

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Section: Methodsmentioning

confidence: 99%

Gastrointestinal Imaging Findings in the Era of COVID-19: A Pictorial Review

Mavropoulou,

Psoma,

Papachristodoulou

et al. 2023

Medicina

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“…Se realizó el análisis estadístico entre ambos grupos, encontrándose diferencias estadísticamente significativas, lo que puede dar a entender que los pacientes con manifestaciones gastrointestinales en el contexto del SARS COV 2 presentan una mayor morbilidad [14][15] .…”

Section: Pág 7719unclassified

“…8 donde se reporta un 40% de intervenciones endoscópicas, al contrario, otros autores como Ü. Alkaus et al 16 que reportan un 1% de intervenciones endoscópicas, mientras que en el presente estudio el grupo no COVID solo un 7% requirió de tratamiento endoscopico con Hemoclip. Dicha diferencia de aplicación de tratamiento endoscópico entre distintos estudios pudiese ser por el comportamiento de evitar los hospitales de la gente por temor al contagio o de agraverse por lo que en algunas poblaciones se captaron casos más severos, como lo explica Ashktorab H. et al 14 .…”

Section: Pág 7719unclassified

Infección por SARS-CoV-2 como Factor de Riesgo para Úlcera Gastro Duodenal en Pacientes del Centro Médico Naval

Hernández Trujillo,

Coppe Gutiérrez

2024

Ciencia Latina

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Introducción: La infección por SARS-CoV-2 es una enfermedad que no solo afecta el aparato respiratorio sino también el aparato digestivo provocando diversas complicaciones. Objetivo: Evaluar la relación que existe entre la formación de ulceras gastro duodenales y la infección por SARS-CoV-2 en pacientes hospitalizados en el Centro Médico Naval. Material y métodos: Se realizo un estudio observacional transversal en pacientes hospitalizados en el Centro Médico Naval comparando la presentación de ulceras gastro duodenales en pacientes de terapia intensiva del área COVID y el área no COVID por medio de endoscopia alta. Resultados: Se captaron 15 pacientes en el grupo COVID, de los cuales el 80% fueron masculinos y de los 15 pacientes en el grupo no COVID 67% fueron femeninos. No hubo diferencia estadística entre la edad de ambos grupos presentándose un promedio de 69 años. En el grupo COVID ulceras tipo Forrest IA y IB en un 36.6% vs un 0% en el grupo no COVID y un 33.3% con ulceras Forrest IIA a IIC del grupo COVID vs un 0% del grupo no COVID con una p>0.0001. La mortalidad fue del 87.5% en el grupo COVID, la mortalidad en el grupo no COVID fue de un 7%, la supervivencia en el grupo COVID fue de 12.5%, mientras que en el grupo no COVID el 93%. Conclusiones: En el presente estudio se concluyó que la infección por SARS-CoV-2 representa un factor de riesgo para el desarrollo de úlceras gástricas y duodenales en pacientes con infección severa, lo cual aumenta la mortalidad en los pacientes que las desarrollan, independientemente del uso de esteroides o anticoagulantes.

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“…A large COVID-19 cohort, mostly from Egypt, reported a high rate of GI bleeding from hematemesis in 9%, melena in 5.3%, hematochezia in 0.6%, and fecal-occult positive stools in 5% [40]. Contrariwise, a systematic review of 12 studies reported a prevalence of GI bleeding of only 0.06% [41]. A European cohort of 4128 COVID-19 subjects noted a 1.8% prevalence of GI bleeding [42].…”

Section: Gastrointestinal (Gi) Bleedingmentioning

confidence: 99%

Evolving Clinical Manifestations and Outcomes in COVID-19 Patients: A Comparative Analysis of SARS-CoV-2 Variant Waves in a Romanian Hospital Setting

Briciu,

Leucuta,

Muntean

et al. 2023

Pathogens

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The aim of this study was to evaluate differences in the clinical manifestations and outcomes in hospitalized patients with COVID-19 in a single Romanian center during four pandemic waves determined by different SARS-CoV-2 variants of concern (VOCs). A retrospective study on 9049 consecutive hospitalized adult patients was performed between 27 February 2020 and 31 March 2023. The study interval was divided into waves based on national data on SARS-CoV-2 VOCs’ circulation. Multivariate logistic regression models were built, predicting death and complications as functions of comorbidities, therapy, wave, severity form, and vaccination status, and adjusted for ages ≥65 years. Pulmonary (pneumothorax/pneumomediastinum, pulmonary embolism) and extrapulmonary complications (liver injury, acute kidney injury, ischemic/hemorrhagic stroke, myocardial infarction, and gastrointestinal bleeding) were present, more frequently in ICU hospitalized patients and with differences between waves. The highest in-hospital mortality was found in patients presenting pneumothorax/pneumomediastinum. All of the evaluated risk factors were significantly associated with death, except for obesity and the Omicron wave. Our study highlights the changing nature of COVID-19 and acknowledges the impacts of viral mutations on disease outcomes. For all four waves, COVID-19 was a severe disease with a high risk of poor outcomes.

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Clinical and Endoscopic Outcomes in COVID-19 Patients With Gastrointestinal Bleeding

Cited by 12 publications

References 39 publications

Gastrointestinal Imaging Findings in the Era of COVID-19: A Pictorial Review

Gastrointestinal Imaging Findings in the Era of COVID-19: A Pictorial Review

Infección por SARS-CoV-2 como Factor de Riesgo para Úlcera Gastro Duodenal en Pacientes del Centro Médico Naval

Evolving Clinical Manifestations and Outcomes in COVID-19 Patients: A Comparative Analysis of SARS-CoV-2 Variant Waves in a Romanian Hospital Setting

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