Clinical and Echocardiographic Characteristics of Papillary Fibroelastomas

Sun, Jing Ping; Asher, Craig R.; Yang, Xing Sheng; Cheng, Georgina; Scalia, G.; Massed, An Malek G; Griffin, Brian P.; Ratliff, Norman B.; Stewart, William J.; Thomas, James D.

doi:10.1161/01.cir.103.22.2687

Cited by 412 publications

(219 citation statements)

References 33 publications

Supporting

Mentioning

209

Contrasting

Unclassified

Order By: Relevance

“…Transesophageal echocardiogram is frequently required for accurate assessment. 2 Definite diagnosis is based on histopathological features. 1 Because of its rarity, there are few data regarding safety and efficacy of thrombolytic therapy in acute ischemic strokes caused by CPF.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stroke and Cardiac Papillary Fibroelastoma: Mechanical Thrombectomy after Thrombolytic Therapy

Santos

Pinho

Ramos

et al. 2014

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

We describe a case of a 34-year-old man with a sudden development of right hemiparesis and aphasia because of infarction of the left middle cerebral artery that was submitted to intravenous (IV) recombinant tissue plasminogen activator and mechanical thrombectomy. Transesophageal echocardiogram showed a small mass on the anterior leaflet of the mitral valve. Cardiac surgery was performed, and histological examination of the removed material was consistent with cardiac papillary fibroelastoma (CPF). Experience in using IV thrombolysis for the treatment of embolic stroke because of CPF is limited. To the best of our knowledge, only 3 patients are reported in literature in whom acute ischemic stroke and associated CPF were treated with thrombolytic therapy. A discussion of the efficacy of IV thrombolysis and the possible superiority of mechanical thrombectomy is included.

show abstract

Section: Discussionmentioning

confidence: 99%

“…1,2 We describe a patient in whom emboli originating from CPF caused cerebral infarction; he was submitted to intravenous (IV) recombinant tissue plasminogen activator and mechanical thrombectomy.…”

Section: Introductionmentioning

confidence: 99%

Stroke and Cardiac Papillary Fibroelastoma: Mechanical Thrombectomy after Thrombolytic Therapy

Santos

Pinho

Ramos

et al. 2014

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

show abstract

“…While typically asymptomatic, CPFs can present with stroke, sudden death, myocardial infarction, heart failure, syncope, pulmonary embolism or peripheral infarction. To date, no recurrences of CPFs after surgical excision have been reported, and the long-term prognosis of these patients appears to be excellent (1)(2)(3)(4).…”

mentioning

confidence: 98%

Mitral and tricuspid valve papillary fibroelastomas: A rare cause of multiple intracardiac masses

Gudgeon

Chow

Abramson

2009

Canadian Journal of Cardiology

View full text Add to dashboard Cite

A 55-year-old woman with no cardiac history presented with increasing shortness of breath on exertion, worsening cough and orthopnea for three weeks. A transthoracic echocardiogram identified two intracardiac masses. Transesophageal echocardiography demonstrated a 1.8 cm × 1.5 cm mass attached to the base of the posterior tricuspid leaflet ( Figure 1A) and a 1.0 cm × 0.5 cm mass attached to the atrial side of the left mitral leaflet ( Figure 1B). Both masses displayed indistinct surface features and neither was attached to the atrial wall or interatrial septum. No other intracardiac pathology was identified. The differential diagnosis included primary cardiac tumour, metastatic malignancy, thrombus or vegetation. After an extensive workup, the patient ultimately went on to have surgical excision of these masses. Surgical pathology confirmed the diagnosis: mitral and tricuspid valve cardiac papillary fibroelastomas (CPFs).CPFs are the second most common primary cardiac tumour in adults. They are benign avascular tumours made of papillary elastin fibrils in a hyaline stroma covered with a single layer of endothelium. These tumours occur most frequently on the aortic and mitral valves, and infrequently on the tricuspid and pulmonic valves. On echocardiography, CPFs are typically small, well-demarcated, highly mobile masses attached to the endocardium by a pedicle. They can have a highly refractive appearance, often with areas of echolucency and a 'speckled' appearance around the perimeter. Multiple CPFs are an exceedingly rare finding. While typically asymptomatic, CPFs can present with stroke, sudden death, myocardial infarction, heart failure, syncope, pulmonary embolism or peripheral infarction. To date, no recurrences of CPFs after surgical excision have been reported, and the long-term prognosis of these patients appears to be excellent (1-4).iMAges in cArdiology

show abstract

“…bo em bo lism ad he red to a tu mo r em bo lism, tu mors, val vu lar di se a se or are fo und in ci den tally. 3,4 We re port a ca se with fib ro e las to ma ad mit ted with angi na. A mass lo ca ted at the aor tic val ve was de tected on ec ho car di og raphy, and it was suc cess fully re sec ted sur gi cally.…”

mentioning

confidence: 99%

Aortic Valve Fibroelastoma: Case Report

Durmaz¹,

Keleş²,

Bayram³

et al. 2011

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

ncidence of primary cardiac tumors in necropsy series ranges between 0.0017% and 0.33%, and the echocardiographic incidence is reported as 0.019%.1 Papillary fibroelastoma is the third most common primary cardiac tumor (accounting for approximately 7% of all primary cardiac tumors) after myxoma and lipoma. It is the most frequent cardiac valvular tumor (70-80%).1,2 Although this tumor can be found anywhere in the heart, it is mostly located at the valvular endocardium (80%). Before the echocardiography era, papillary fibroelastomas were detected coincidentally at autopsies. However, several advancements in transthoracic (TTE) and transesophageal (TEE) echocardiography enable us to diagnose this entity Case Report A AB BS S T TR RA AC CT T Fib ro e las to mas are the most com mon be nign car di ac tu mo rs in vol ving the car di ac valves. Alt ho ugh this tu mo r can be fo und any whe re in the he art, mostly it is lo ca ted at the val vu lar en do car di um. Alt ho ugh pa pil lary fib ro e las to mas are de tec ted co in ci den tally as an au topsy fin ding, se ve ral ad van ce ments and in cre a sed ava i li a bi lity in ec ho car di og raphy enab le us to di ag no se this en tity ear li er. Fib ro e las to mas may re sult in se ve ral cli ni cal con di ti ons es pe ci ally such as em bo li zati on (isc he a mic stro ke, myo car di al in farc ti on). We re port a 68-ye ar-old ma le pa ti ent ad mit ted with chest pa in and di ag no sed by ec ho car di og rap hic eva lu a ti on to ha ve a lar ge mo bi le mass with a pedic le ad he red to the aor tic si de of right co ro nary cusp. The tumor was sur gi cally re mo ved to avo id an em bo lic event and his to pat ho lo gi cal exa mi na ti on con fir med the di ag no sis to be a car di ac pa pil lary fib ro e las to ma, which is the most com mon be nign val vu lar ne op lasm of the he art.K Ke ey y W Wo or rd ds s: : He art ne op lasms; aor tic val ve Ö ÖZ ZE ET T Fib ro e las tom lar kalp ka pak çık la rı nı tu tan en yay gın iyi huy lu kar di yak tü mör ler dir. Her ne ka dar bu tü mör kal bin her ye rin de gö rü le bil se de, ge nel lik le en yay gın lo ka li zas yo nu val vu lar endo kar di yum dur. Bu nun la be ra ber, her ne ka dar pa pil ler fib ro e las tom lar otop si sı ra sın da te sa dü fen bu lun sa da, eko kar di yog ra fi nin yay gın ola rak kul la nıl ma sı bu ol gu la rı er ken dö nem de teş his et memi ze ola nak sağ la mak ta dır. Fib ro e las tom lar em bo li zas yon baş ta ol mak üze re ba zı has ta lık la ra yol aça rak kar şı mı za çı ka bi lir (is ke mik in me, mi yo kard en fark tü sü). Bu ra da, kli ni ği mi ze gö ğüs ağ rı sı şika ye ti ile baş vu ran 68 ya şın da ki bir er kek has ta yı su nu yo ruz. Has ta nın eko kar di yog ra fik in ce lenme sin de sağ ko ro ner ka pak çı ğın aor tik ta ra fı na ya pı şık bü yük mo bil pe di kü ler kit le tes pit edil di. Ola sı bir em bo li yi ön le mek ama cıy la, kit le cer ra hi ope ras yon la alın dı. Kit le nin his to pa to lo jik in celen me si en yay gın kalp ka pak çı ğı tü mö rü olan kar di y...

show abstract

Clinical and Echocardiographic Characteristics of Papillary Fibroelastomas

Cited by 412 publications

References 33 publications

Stroke and Cardiac Papillary Fibroelastoma: Mechanical Thrombectomy after Thrombolytic Therapy

Stroke and Cardiac Papillary Fibroelastoma: Mechanical Thrombectomy after Thrombolytic Therapy

Mitral and tricuspid valve papillary fibroelastomas: A rare cause of multiple intracardiac masses

Aortic Valve Fibroelastoma: Case Report

Contact Info

Product

Resources

About