Clinical and cytokine profile evaluation in Northeast Brazilian psoriasis plaque-type patients

Cardoso, Pablo Ramon Gualberto; Lima, Emerson; Lima, Mariana Modesto de Andrade; Rêgo, Moacyr Jesus Barreto de Melo; Marques, Cláudia Diniz Lopes; Pitta, Ivan da Rocha; Duarte, Ângela Luzia Branco Pinto; Pitta, Maíra Galdino da Rocha

doi:10.1684/ecn.2016.0371

Cited by 28 publications

(26 citation statements)

References 44 publications

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“…For example, the IL-10 concentrations or the number of CD4þCD10þ or CD4þCD25þFoxp3þ T cells can be dramatically induced by IL-35; however, this cytokine can decrease the total number of macrophages and lower the ratio of M1/M2 macrophages, which are dominant in the innate immunity (10). However, Pablo et al have reported that expression of IL-35 does not differ significantly between patients with plaque-type psoriasis and normal individuals (22). Thus, the role IL-35 plays in psoriasis and its underlying mechanism are not completely clear.…”

Section: Discussionmentioning

confidence: 99%

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Clinical significance of weak interleukin‐35 expression in patients with psoriasis

Liu

et al. 2018

Microbiology and Immunology

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In psoriasis, a chronic, recurrent, inflammatory skin disease, CD4+T cells and their related cytokines play an important role in its pathogenesis. The role of interleukin (IL)-35, an immunosuppressive cytokine involved in many autoimmune diseases, is unclear in the pathogenesis of psoriasis. This study evaluated IL-35 expression and clinical significance in psoriasis. Protein and mRNA levels of specified markers were measured by enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR), respectively. Results showed that plasma IL-35 concentrations were lower in patients with psoriasis than in healthy individuals (Z = -6.525, P < .0001). Ebi3 and p35 showed lower mRNA levels in peripheral blood mononuclear cells from patients with psoriasis than in healthy individuals (Z = -5.078, P < .0001, Z = -2.609, P = .009, respectively). The areas under the receiver-operating characteristic (ROC) curves of IL-35, Ebi3, and p35 for patients with psoriasis versus the control were 0.86, 0.78, and 0.64, respectively. Pearson correlation analysis showed that plasma IL-35 expression negatively correlated with interferon-gamma, tumor necrosis factor-alpha, levels of IL-23, -17, and -22, or the Psoriasis Activity and Severity Index and positively correlated with levels of transforming growth factor beta and IL-10 levels in patients with psoriasis. Summarily, IL-35 might mediate psoriasis pathogenesis by influencing the expression of Th1/Th17/T -related cytokines and might be a putative target in monitoring or treating psoriasis.

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Section: Discussionmentioning

confidence: 99%

“…However, Pablo et al . have reported that expression of IL‐35 does not differ significantly between patients with plaque‐type psoriasis and normal individuals . Thus, the role IL‐35 plays in psoriasis and its underlying mechanism are not completely clear.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of weak interleukin‐35 expression in patients with psoriasis

Liu

et al. 2018

Microbiology and Immunology

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“…The immune system, especially CD4+ T cells, plays a crucial role in the pathogenesis of psoriasis. Activated CD4+ T cells secrete higher levels of cytokines, such as interferon (IFN)‐γ and interleukin (IL)‐17A, which could promote keratinocyte proliferation . Activation of T cells requires two signals: (i) the interaction of T‐cell receptor (TCR) and major histocompatibility complex (MHC) class I/II, and (ii) the interaction of costimulatory/inhibitory molecules .…”

Section: Introductionmentioning

confidence: 99%

TIGIT expression levels on CD4+ T cells are correlated with disease severity in patients with psoriasis

Wang

et al. 2018

Clin Exp Dermatol

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“…12 Similarly, serum levels of IL-29 were elevated in psoriasis patients as compared to healthy controls. 37 IL-29 levels were significantly higher in the skin of AD patients when compared to healthy controls. 38 Hashimoto's thyroiditis (HT) is a typical autoimmune thyroid disease.…”

Section: Il-29 Expression In Inflammatory Autoimmune Disordersmentioning

confidence: 81%

“…Levels of IL‐29 in psoriatic lesions positively correlated with antiviral protein expression . Similarly, serum levels of IL‐29 were elevated in psoriasis patients as compared to healthy controls . IL‐29 levels were significantly higher in the skin of AD patients when compared to healthy controls .…”

Section: Il‐29 and Inflammatory Autoimmune Diseasesmentioning

confidence: 86%

Insights into IL‐29: Emerging role in inflammatory autoimmune diseases

Wang

Huang

et al. 2019

J Cellular Molecular Medi

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Interleukin‐29 (IL‐29) is a newly discovered member of type III interferon. It mediates signal transduction via binding to its receptor complex and activates downstream signalling pathways, and therefore induces the generation of inflammatory components. Recent studies reported that expression of IL‐29 is dysregulated in inflammatory autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, Sjögren's syndrome, psoriasis and systemic sclerosis. Furthermore, functional analysis revealed that IL‐29 may involve in the pathogenesis of the inflammatory autoimmune disorders. In this review, we will systematically review the current knowledge about IL‐29. The information collected revealed the regulatory role of IL‐29 and may give important implications for its potential in clinical treatment.

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Clinical and cytokine profile evaluation in Northeast Brazilian psoriasis plaque-type patients

Cited by 28 publications

References 44 publications

Clinical significance of weak interleukin‐35 expression in patients with psoriasis

Clinical significance of weak interleukin‐35 expression in patients with psoriasis

TIGIT expression levels on CD4+ T cells are correlated with disease severity in patients with psoriasis

Insights into IL‐29: Emerging role in inflammatory autoimmune diseases

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