Clinical and color Doppler ultrasound evaluation of polyacrylamide injection in <scp>HIV</scp> patients with severe facial lipoatrophy secondary to antiretroviral therapy

Faúndez, Eliana; Vega, Nadia; Vera, E.; Vega, Pedro; Sepúlveda, Dino; Wortsman, Ximena

doi:10.1111/srt.12329

Cited by 7 publications

(13 citation statements)

References 24 publications

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“…Nevertheless, to date, there are reports on the ultrasonographic appearance of some of these conditions such as vascular malformations, lipodermatosclerosis, eosinophilic fasciitis, keloids, chronic graft versus host disease, lipodystrophy, mycosis fungoides, and dermatofibrosarcoma protuberans. Eosinophilic fasciitis and chronic graft versus host disease present some similar ultrasonographic findings to morphea, which support the hypothesis that these entities may be variants of the presentation of morphea 4,5,12–18 . Table 2 summarizes the main ultrasonographic findings of active morphea and their main differential ultrasonographic diagnoses.…”

Section: Discussionsupporting

confidence: 64%

“…Eosinophilic fasciitis and chronic graft versus host disease present some similar ultrasonographic findings to morphea, which support the hypothesis that these entities may be variants of the presentation of morphea. 4,5,[12][13][14][15][16][17][18] Table 2 summarizes the main ultrasonographic findings of active morphea and their main differential ultrasonographic diagnoses.…”

Section: Discussionmentioning

confidence: 99%

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Sun Sign in the Ultrasound Diagnosis and Activity Assessment of Morphea

Salgueiro

Baeza

Moll

et al. 2021

J of Ultrasound Medicine

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Morphea, a localized form of scleroderma, is a chronic inflammatory autoimmune disease of the skin. Color Doppler Ultrasound has been reported as a reliable tool to assess the activity of the disease. With histologically confirmed cases, this case series describes a new ultrasound sign consisting of a hyperechoic halo surrounding superficial subcutaneous veins of the extremities in transverse view, named the sun sign. This sign can help diagnose morphea in the inflammatory phase and correlate in pathology with perivascular infiltrates surrounding superficial subcutaneous veins.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Sun Sign in the Ultrasound Diagnosis and Activity Assessment of Morphea

Salgueiro

Baeza

Moll

et al. 2021

J of Ultrasound Medicine

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“…[13][14][15]19 In the clinical practice setting, ultrasound examination can support the diagnosis and treatment of early and late complications. 16,17,[19][20][21][22] In the case of hyaluronic acid fillers, hyaluronidase can be placed with ultrasound-guided injections exactly into the filler deposit. 11,23 The use of color Doppler, as in other indications of ultrasound, has been strongly suggested.…”

Section: Introductionmentioning

confidence: 99%

Nomenclature proposal for the sonographic description and reporting of soft tissue fillers

Schelke

Cassuto

Velthuis

et al. 2019

J of Cosmetic Dermatology

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Background: There is a steady increase in publications about the use of ultrasound and filler treatments, written by physicians from different specialties. The terminology used to describe the ultrasound images of fillers is not uniform, making the different articles difficult to compare. Standardization of the descriptions based on their basic sonographic parameters is recommendable. Aims:The purpose of this study is to propose a nomenclature for the sonographic description and reporting of cosmetic fillers.Methods: An assessment of articles indexed for MEDLINE/PubMed and Embed electronic database was conducted; in total of 39 articles could be included.Results: All articles were investigated for their sonographic descriptions of soft tissue fillers. Ten parameters used for describing and monitoring soft tissue fillers were distinguished. Conclusion:The proposed sonographic descriptions for cosmetic fillers may contribute to a better standardization and understanding fillers ultrasound images in the reports or literature.

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“…This filler has been proven to be stable, nontoxic, nonallergenic, nonembryotoxic and nonabsorbable [38]. PH produces an increase in subcutaneous thickness of both nasolabial lines, which is maintained even after 36 months from its application [39].…”

Section: Discussionmentioning

confidence: 99%

“…Faundez et al proposed a sonographic evaluation after the filling procedure to identify filler deposits, which show up as anechoic pseudocystic structures. It also allowed for the possibility to assess the rise in thickness of the treated area [39].…”

Section: Discussionmentioning

confidence: 99%

Polyacrylamide Injection vs. Polylactic Acid in HIV Related Lipodystrophy: A RCT Systematic Review

et al. 2021

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Lipodystrophy is an alteration of fat metabolism that commonly affects HIV-1 positive patients treated with antiretroviral therapy (ART). The facial area is most commonly affected by peripheral lipoatrophy, thus becoming a social stigma related to chronic HIV. Several treatments have been proposed, such as modification of diet, lifestyle and both surgical and nonsurgical procedures. The goal of our systematic review is to examine published clinical studies involving the use of polyacrylamide filler for the treatment of HIV FLA, and to provide evidence-based recommendations based on published efficacy and safety data. Our research was performed on published literature until April 2021. Polyacrylamide gel is a volumetric gel that has been proven stable, nontoxic, nonallergenic, nonembryotoxic and nonabsorbable. Poly-l-lactic acid (PLA) is a biocompatible, biodegradable, synthetic polymer derived from lactic acid. We believe it is essential to draft a pre- and post-injection and operative protocol to define an even setting for the clinical condition. It is desirable that such specifications are included in a large randomized controlled trial and the follow up is longer than the studies that we found, because as we have seen in the literature there are reported adverse events even 3 or 5 years after the injections.

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Clinical and color Doppler ultrasound evaluation of polyacrylamide injection in HIV patients with severe facial lipoatrophy secondary to antiretroviral therapy

Abstract: Treatment of facial lipoatrophy with PAAG seems to be effective in HIV patients and no signs of complications were observed in the monitoring at 36 months after injection. Color Doppler ultrasound can identify the filler deposits and the anatomical changes of the SCT non-invasively.

Cited by 7 publications

References 24 publications

Sun Sign in the Ultrasound Diagnosis and Activity Assessment of Morphea

Sun Sign in the Ultrasound Diagnosis and Activity Assessment of Morphea

Nomenclature proposal for the sonographic description and reporting of soft tissue fillers

Polyacrylamide Injection vs. Polylactic Acid in HIV Related Lipodystrophy: A RCT Systematic Review

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