Sun Sign in the Ultrasound Diagnosis and Activity Assessment of Morphea

Salgueiro, Catalina; Baeza, J.; Moll, Carlo; Alfaro-Sepúlveda, Daniela; Mellado, Gonzalo; Villaseca-Hernández, Miguel; Vera‐Kellet, Cristián; Wortsman, Ximena

doi:10.1002/jum.15843

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…The sun sign (ie, hyperechoic halo surrounding subcutaneous venous vessels) suggests morphea (Figure 16). This sign correlates with inflammatory perivascular infiltrates commonly found in the pathology samples 135 …”

Section: Advances In Inflammatory Diseasessupporting

confidence: 66%

“…This sign correlates with inflammatory perivascular infiltrates commonly found in the pathology samples. 135 Ultrasound can support the monitoring of cutaneous ulcers in scleroderma patients 136 and detect early signs of morphea after liposuction. 137 Recently, a sonographic scoring of the activity of morphea called (US-MAS) was described, which can be essential to track the effectiveness of the treatment.…”

Section: Advances In Inflammatory Diseasesmentioning

confidence: 99%

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Top Advances in Dermatologic Ultrasound

Wortsman

2022

J of Ultrasound Medicine

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The advances in dermatologic ultrasound have been significantly influenced by the development of high‐ and ultrahigh‐frequency probes, the provision of guidelines for performing the examinations, and a growing number of publications in the field. This review analyzes the most significant contributions that have impacted the daily practice of dermatologists in recent years. This includes the advances in anatomical detection and the patterns of benign and malignant cutaneous tumors, inflammatory dermatologic conditions, vascular anomalies, nail abnormalities, and aesthetic procedures. The knowledge of these advances is a primer for the operators of these examinations.

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Section: Advances In Inflammatory Diseasessupporting

confidence: 66%

Section: Advances In Inflammatory Diseasesmentioning

confidence: 99%

Top Advances in Dermatologic Ultrasound

Wortsman

2022

J of Ultrasound Medicine

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“…Color Doppler may also be helpful to identify disease activity, since active lesions are characterized by an increased blood flow and subcutaneous hyperechogenicity ( 110 ). Recently, Salgueiro et al ( 111 ) proposed a novel diagnostic ultrasound sign for morphea, called the “sun sign”. This consists of a hyperechogenic halo surrounding superficial subcutaneous veins of the extremities in transverse view.…”

Section: Diagnosismentioning

confidence: 99%

Morphea: The 2023 update

et al. 2023

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Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue disorder with variable clinical presentations, that affects both adults and children. It is characterized by inflammation and fibrosis of the skin and underlying soft tissue, in certain cases even of the surrounding structures such as fascia, muscle, bone and central nervous system. While the etiology is still unknown, many factors may contribute to disease development, including genetic predisposition, vascular dysregulation, TH1/TH2 imbalance with chemokines and cytokines associated with interferon-γ and profibrotic pathways as well as certain environmental factors. Since the disease may progress to permanent cosmetic and functional sequelae, it is crucial to properly assess the disease activity and to initiate promptly the adequate treatment, thus preventing subsequent damage. The mainstay of treatment is based on corticosteroids and methotrexate. These, however, are limited by their toxicity, especially if applied long-term. Furthermore, corticosteroids and methotrexate often do not sufficiently control the disease and/or the frequent relapses of morphea. This review presents the current understanding of morphea by discussing its epidemiology, diagnosis, management and prognosis. In addition, it will describe recent pathogenetic findings, thus proposing potential novel targets for therapeutic development in morphea.

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