Clinical and biological significance of Nemo-like kinase expression in glioma

Cui, Gang; Li, Zhen; Shao, Bai; Zhao, Li; Zhou, Yanfeng; Lü, Ting; Wang, Jun-Xiang; Shi, Xioayong; Wang, Jinjin; Zuo, Gang; Zhu, Weiwei; Shen, Aiguo

doi:10.1016/j.jocn.2010.05.037

Cited by 33 publications

(26 citation statements)

References 28 publications

(23 reference statements)

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“…In glioma, the expression of NLK in glioma is inversely related to the glioma grading. NLK may be a useful independent prognostic indicator for glioma (Cui et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Nemo-like Kinase Increases Taxol Sensitivity in Laryngeal Cancer

Dong

Guo²,

Zhao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…In glioma, the expression of NLK in glioma is inversely related to the glioma grading. NLK may be a useful independent prognostic indicator for glioma (Cui et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Nemo-like Kinase Increases Taxol Sensitivity in Laryngeal Cancer

Dong

Guo²,

Zhao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The Wnt/β-catenin signaling is thought to play a critical role in human carcinogenesis, so it is possible that NLK can act as a tumor suppressor by regulating the Wnt/β-catenin pathway. Cui et al (3) found that NLK induced apoptosis in glioma cells via the activation of caspases, and suggested that NLK might be a useful independent prognostic indicator for glioma. Gene therapeutic approaches aimed at upregulating NLK expression could be developed for treatment of glioma.…”

Section: █ Conclusionmentioning

confidence: 99%

Differential expression of micrornas in medulloblastoma and the potential functional consequences

Zhang

Li²,

Liang³

et al. 2017

Turkish Neurosurgery

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“…17 Clinical data show that NLK expression is significantly associated with the pathologic cancer grade and is correlated with cell proliferation and apoptosis. 29,30 Recently, NLK has been associated with hepatocellular malignant transformation and proliferation. 31 Thus, the precise role of NLK in tumorigenesis is still unclear and warrants further investigation.…”

Section: Anti-p53mentioning

confidence: 99%

Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage

et al. 2014

Cell Death Differ

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The DNA damage response (DDR) acts as a protective mechanism for maintaining cell homeostasis. Nemo-like kinase (NLK) is a serine/threonine-protein kinase that has an important role in many pathways; however, its function in the DDR has not yet been defined. In our study, NLK-deficient HCT116 cells were found to be resistant to etoposide-induced cell death. We demonstrated that NLK is required for p53 activation in response to DNA damage. Remarkably, mechanistic studies revealed that NLK interacts with p53 and stabilizes p53 by blocking MDM2-mediated p53 ubiquitination and degradation. Furthermore, NLK enhances p53 activity and affects expression downstream of p53. Interestingly, these functions of NLK are not related to its kinase activity. Consistent with these results, NLK-deficient cells have a resistance effect on DNA damage. Therefore, these findings emphasize that NLK is a novel factor in DDR mechanisms.

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Clinical and biological significance of Nemo-like kinase expression in glioma

Cited by 33 publications

References 28 publications

Inhibition of Nemo-like Kinase Increases Taxol Sensitivity in Laryngeal Cancer

Inhibition of Nemo-like Kinase Increases Taxol Sensitivity in Laryngeal Cancer

Differential expression of micrornas in medulloblastoma and the potential functional consequences

Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage

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