Differential expression of micrornas in medulloblastoma and the potential functional consequences

Zhang, Yuting; Li, Lusheng; Liang, Ping; Zhai, Xuan; Li, Yingliang; Zhou, Yifeng

doi:10.5137/1019-5149.jtn.19379-16.2

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Over the last few years, increasing evidence suggest that ncRNAs can be used as biomarkers for the early diagnosis and long‐term survival prediction of MB. Moreover, the expression profiles of specific ncRNAs are valuable for tumor classification, targeted therapy, and individualized intervention …”

Section: Introductionmentioning

confidence: 99%

Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes

Miao

et al. 2018

Cancer Medicine

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Circular RNAs (circRNAs) have been demonstrated to be involved in various biological processes. Nevertheless, the function of circRNAs in medulloblastoma (MB) is still unknown. The present study aimed to investigate the expression profiles of circRNAs and related mechanisms for regulating the proliferation and growth of tumor cells in MB. The expression profiles of circRNAs were screened from four normal cerebellum and four MB samples using a HiSeq Sequencer. Bioinformatic analysis was employed to predict the interaction between circRNAs and mRNAs in MB. Subsequently, the expression levels of eight differential circRNAs [circ‐SKA3 (hsa_circ_0029696), circ‐DTL (hsa_circ_0000179), circ‐CRTAM, circ‐MAP3K5 (hsa_circ_0006856), circ‐RIMS1‐1 (hsa_circ_0132250), circ‐RIMS1‐2 (hsa_circ_0076967), circ‐FLT3‐1 (hsa_circ_0100165), and circ‐FLT3‐2 (hsa_circ_0100168)] were validated using quantitative reverse transcription−polymerase chain reaction. Moreover, circ‐SKA3 and circ‐DTL were silenced using small interfering RNAs and their host genes were overexpressed to investigate their role in the pathogenesis of MB. A total of 33 circRNAs were found to be differentially expressed in MB tissues (fold change ≥ 2.0, FDR <0.05), of which three were upregulated and 30 were downregulated; six circRNAs were experimentally validated successfully. Upregulated circ‐SKA3 and circ‐DTL promoted the proliferation migration and invasion in vitro by regulating the expression of host genes. This novel study exploited the profiling of circRNAs in MB and demonstrated that circ‐SKA3 and circ‐DTL were crucial in the tumorigenesis and development of MB and might be considered as novel and potential biomarkers for the diagnosis and new targets for the intervention of MB.

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Section: Introductionmentioning

confidence: 99%

Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes

Miao

et al. 2018

Cancer Medicine

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“…Wan et al [ 48 ] found that HECTD4 was prominently elevated in CHOL tissues. Zhang et al [ 49 ] used bioinformatics analysis to identify RAPGEF2 as potential target genes in the Wnt and MAPK signaling pathways of Medulloblastoma. These genes were also highly expressed in our study, but their expression status in GBM has not been reported.…”

Section: Resultsmentioning

confidence: 99%

The regulatory pattern of target gene expression by aberrant enhancer methylation in glioblastoma

Zhao

Shi-jia

et al. 2021

BMC Bioinformatics

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Background Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor with grim prognosis. Aberrant DNA methylation is an epigenetic mechanism that promotes GBM carcinogenesis, while the function of DNA methylation at enhancer regions in GBM remains poorly described. Results We integrated multi-omics data to identify differential methylation enhancer region (DMER)-genes and revealed global enhancer hypomethylation in GBM. In addition, a DMER-mediated target genes regulatory network and functional enrichment analysis of target genes that might be regulated by hypomethylation enhancer regions showed that aberrant enhancer regions could contribute to tumorigenesis and progression in GBM. Further, we identified 22 modules in which lncRNAs and mRNAs synergistically competed with each other. Finally, through the construction of drug-target association networks, our study identified potential small-molecule drugs for GBM treatment. Conclusions Our study provides novel insights for understanding the regulation of aberrant enhancer region methylation and developing methylation-based biomarkers for the diagnosis and treatment of GBM.

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“…In non-small cell lung cancer cells, α 2 δ 1 expression confers radioresistance in vitro , by enhancing the DNA repair response, and chemoresistance in vivo , potentially through MAPK signalling [ 72 , 73 ]. In addition, various miRNAs that are downregulated in cancer target α 2 δ 1 expression, including hsa-miR-208a-3p and hsa-miR-1207-5p in medulloblastoma [ 74 ], and miR-107 in chronic myeloid leukaemia (CML) [ 75 ]. Overexpressing miR-107 promotes differentiation in CML cell lines, which is reversed when expression of α 2 δ 1 is restored [ 75 ].…”

Section: Ca 2+ Channelsmentioning

confidence: 99%

Emerging roles for multifunctional ion channel auxiliary subunits in cancer

Haworth

Brackenbury

2019

Cell Calcium

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Differential expression of micrornas in medulloblastoma and the potential functional consequences

Cited by 6 publications

References 16 publications

Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes

Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes

The regulatory pattern of target gene expression by aberrant enhancer methylation in glioblastoma

Emerging roles for multifunctional ion channel auxiliary subunits in cancer

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