Clinical and biochemical profile of patients with viral hepatitis at tertiary care centre

Abstract

Background: Viral hepatitis is known since ancient times. Hepatitis is an inflammation of the liver, most commonly caused by a viral infection. Different species of viruses, including Cytomegalovirus, Epstein-Barr, Herpes simplex, Adenovirus, Coxsackie virus and others cause parenchymal hepatic inflammation, but the term viral hepatitis generally implies to the five hepatotropic viruses: Hepatitis A, B, C, D and E virus.Methods: This observational study was done from August 2014 to November 2016 in department of medicine of a medical college using a structured questionnaire.Results: Anorexia was the most common symptom; followed by fatigue; nausea and vomiting. Total serum bilirubin and direct serum bilirubin were raised in all cases of hepatitis A and E. Raised SGPT and SGOT were observed in all cases of Hepatitis A and E. Among 43 patients of hepatitis B, SGPT and SGOT were raised in 32 and 31 cases respectively. Raised alkaline phosphatase was observed in 27; 25 and 16 cases of hepatitis A; B and E respectively. Raised prothrombin time was observed in 12; 11; 01and 09 of Hepatitis A; B; C and E cases respectively.Conclusions: Viral hepatitis is an important heath care problem in India as it occurs epidemically and sporadically. The variability in nature of the disease regarding its onset, presenting symptoms, clinical course and development of complications are important aspects. So, it is very essential for health care professionals to be aware of all aspects of it so that it is detected and treated early.

Clinicohematological Profiles of Hepatitis B Virus (Hbv): Observations From a Tertiary Care Centre

“…In western Indian population, HBV infected patients have not shown any derangement of the hematological parameters like haemoglobin and total leukocyte count 18 , whereas we have seen statistically significant change in TLC (Table 2) The liver parenchymal cells are the primary target for HBV there is very high derangement in the liver function tests i.e., decrease in serum albumin, total protein, and increase in total bilirubin and hepatic enzymes 20 . The liver enzymes like ALT, AST , ALP were raised in more than 70% of the HBV patients and increased in total bilirubin in 80% of the case has been reported in Indian population 18 as we have observed in our cohort of study population.…”

“…In our study population, HBV infection was presented mainly with fever (73.91%), in contrast to fever with right hypochondriac region pain and Anorexia with Vomiting was the commonest symptoms in patients with HBV in North Indian 19 and Western Indian patients 18 , respectively. In western Indian population, HBV infected patients have not shown any derangement of the hematological parameters like haemoglobin and total leukocyte count 18 , whereas we have seen statistically significant change in TLC (Table 2) The liver parenchymal cells are the primary target for HBV there is very high derangement in the liver function tests i.e., decrease in serum albumin, total protein, and increase in total bilirubin and hepatic enzymes 20 .…”

“…A total of 260 patients with HBsAg were diagnosed in our hospital during the study period. Incidence of HBV varies from 16-43% in acute viral hepatitis patients in Indian population 18,19 .…”

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“…In our study population, HBV infection was presented mainly with fever (73.91%), in contrast to fever with right hypochondriac region pain and Anorexia with Vomiting was the commonest symptoms in patients with HBV in North Indian 19 and Western Indian patients 18 , respectively. In western Indian population, HBV infected patients have not shown any derangement of the hematological parameters like haemoglobin and total leukocyte count 18 , whereas we have seen statistically significant change in TLC (Table 2) The liver parenchymal cells are the primary target for HBV there is very high derangement in the liver function tests i.e., decrease in serum albumin, total protein, and increase in total bilirubin and hepatic enzymes 20 . The liver enzymes like ALT, AST , ALP were raised in more than 70% of the HBV patients and increased in total bilirubin in 80% of the case has been reported in Indian population 18 as we have observed in our cohort of study population.…”

Prevalence of Acute Viral Hepatitis in Symptomatic Patients in a Tertiary Care Hospital of North India

“…Hepatitis symptoms are so nonspecific, perfect diagnosis cannot be achieved through history and physical examination alone. An accurate diagnosis can only be made by testing patients' sera for the presence of specific anti-viral antigens or antibodies" [4]. "The variability in nature of the disease regarding its onset, presenting symptoms, clinical course and development of complications in viral hepatitis are important aspects which require clinical attention from time to time.…”