Clinicohematological Profiles of Hepatitis B Virus (Hbv): Observations From a Tertiary Care Centre

Abstract

Aim: In humans, Hepatitis B virus(HBV) is arguably the most common organ specific virus affecting the liver. The pathological sequelae and stages especially in the liver are well studied. However reports on the effect of HBV on the extrahepatic organs are lacking. The present study was carried out to ascertain clinical presentations and the alterations on the haematological and hepatic parameters. Material and Methods: This was a retrospective study and was conducted in a tertiary care hospital in India. Data was collected and analyzed in people who were confirmed to be affected only by HBV by the standard diagnostic method using the HB surface Antigen (HBsAg) for the period January 2016 to December 2016. Results: The results indicated that during the study period, a total of 233 people were included in the study and compared with healthy individuals who were coming for regular health check up and were tested negative for any infectious and chronic diseases. Of these 46 were symptomatic, while 187 were asymptomatic and were diagnosed incidentally during routine/mandatory investigation before surgery. In the 46 symptomatic patient's fever (73.91%), jaundice (63.04%), loss of appetite (39.12%), nausea & vomiting (52.17%), fatigue (28.26%), abdominal pain (17.39%) and Ascites (8.69%) were seen. There was a significant difference in the various haematological, hepatic and electrolyte endpoints (p < 0.05 to 0.0001). Conclusion: The study indicates that acute infection with HBV causes changes in the alterations in haematological, hepatic and electrolytes in the serum.