Clinical and biochemical predictors of increased carotid intima-media thickness in overweight and obese adolescents with type 2 diabetes

Kotb, Nesreen A; Gaber, Rania; Salama, Mai; Nagy, Hala; Elhendy, Abdou

doi:10.1177/1479164111421804

Cited by 24 publications

(23 citation statements)

References 23 publications

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“…Our study showed significant strong positive correlation between CIMT and CRP level among group I and group II with P <0.001. These reslts coincide with kotb et al [11] who stated that CIMT were significantly greater in adolescents with T2DM than in healthy subjects and correlated positively with C-reactive protein. They showed a significant elevation of hypersensitive C-reactive protein in uncontrolled than in controlled diabetic patients and this correlated positively with CIMT.…”

Section: Discussionsupporting

confidence: 68%

“…Patients with T2DM have a two to fourfold increased incidence of CVD compared to persons without diabetes, which is also reflected by an increased CIMT in T2DM patients [1]. Kotb et al [11] found that CIMT was higher in diabetic patients than in healthy subjects. CIMT, HbA1C, systolic blood pressure, triglycerides, HOMA, and C-reactive protein were significantly higher in patients with uncontrolled than with controlled diabetes.…”

Section: Discussionmentioning

confidence: 99%

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Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

Mizar

Hussein

Mashaheet

et al. 2014

International Journal of Basic and Applied Sciences

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Background: Type 2 diabetes mellitus (T2DM) is an inflammatory atherosclerotic condition with high prevalence of cardiovascular disease. Elevated C-reactive protein (CRP) predicts cardiovascular events in T2DM patients. Objectives: Our work aimed to assess sensitivity and specificity of CRP in diagnosis and follow up of carotid atherosclerosis in T2DM patients (detected by measuring carotid intima-media thickness CIMT). Design and setting: It is observational cross sectional study on T2DM patients from outpatient clinic of fayoum university hospital. Subjects and methods: Hundred patients with T2DM were included; Group I: statin un-treated, Group II: statin treated, and fifty healthy control persons. Laboratory measurement of total cholesterol, LDL, HDL, and serum CRP levels and carotid duplex scanning were done. Results: The patients had higher levels of CRP and CIMT than control. There was strong correlation between CIMT and CRP level among group I and II. LDL in diagnosis of atherosclerosis disease illustrated sensitivity (80%) and specificity (4%), while HDL sensitivity (96%) and specificity (36%). CRP showed higher sensitivity (98%) and higher specificity (72%). Conclusion: CRP level was an important parameter of atherosclerosis with good sensitivity and specificity regardless the level of LDL and HDL.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

Mizar

Hussein

Mashaheet

et al. 2014

International Journal of Basic and Applied Sciences

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“…250 Urbina et al 251 found that arterial stiffness, as measured by brachial artery distensibility and pulse-wave velocity, was associated with HOMA (homeostasis model assessment)-assessed IR in adolescents and young adults with T2DM, although not independently of age, sex, BMI, and BP. Similarly, Kotb et al 103 found that cIMT was higher in adolescents with T2DM than in control subjects and correlated with HOMA-assessed IR. Nadeau et al 250 reported reduced cardiopulmonary fitness in adolescents with T2DM compared with lean and obese adolescents, and this reduction in V .…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 99%

“…[93][94][95][96][97] Factors associated with this higher cIMT include lower vitamin C levels 98 and longer duration of disease. 99,100 Adolescents with T2DM also demonstrate higher cIMT compared with healthy control subjects, 101,102 with diabetes mellitus duration 103 and glucose control playing a role. 104 Factors affecting the progression of cIMT in adolescents and young adults with diabetes mellitus include the number of receptors for advanced glycation end products, 105 HbA 1c , 106 and diabetes mellitus duration.…”

mentioning

confidence: 99%

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Maahs¹,

Daniels²,

Ferranti³

et al. 2014

Circulation

159

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“…The increase in the thickness of the carotid intima-media, measured by high-resolution ultrasonography, has been directly associated with atherosclerosis, myocardial infarction and stroke, high-resolution B-mode ultrasonography provides a noninvasive method that can detect an increase in arterial wall thickness [6]. …”

mentioning

confidence: 99%

Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

Rubio-Guerra¹,

Cabrera-Miranda²,

Vargas‐Robles

et al. 2013

Cardiology

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Background: Hypoadiponectinemia and hyperresistinemia are associated with cardiovascular disease. The increase in the carotid intima-media thickness (CIMT) assessed by B-mode ultrasound has been directly associated with increased risk of myocardial infarction and stroke. Objective: To evaluate the correlation between adipokine levels with CIMT in hypertensive type 2 diabetic patients. Methods: Serum levels of adiponectin and resistin levels were measured by ELISA in 30 type 2 diabetic patients with never-treated hypertension and in age-matched healthy controls. The CIMT (B-mode color imaging of extracranial carotid arteries using high-resolution ultrasound) was also obtained. The relationship between adipokine levels and the adiponectin/resistin index with the CIMT was assessed by the Pearson correlation coefficient test. Results: Adiponectin was lower (p < 0.05), and resistin higher (p < 0.01)in patients than in controls, CIMT correlated positively with resistin (R = 0.45, p < 0.02) and the adiponectin/resistin index (R = 0.58, p < 0.001), but not with adiponectin levels (r = -0.11, p > 0.1) in patients. Whereas only adiponectin levels correlated - negatively - with CIMT (r = -0.39, p < 0.02) in controls. Conclusion: Our results shown that the adiponectin/resistin index seems to be more strongly associated with atherosclerosis than adipokine levels, and may be used as a reliable marker of cardiovascular risk in type 2 diabetic hypertensive patients.

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Clinical and biochemical predictors of increased carotid intima-media thickness in overweight and obese adolescents with type 2 diabetes

Abstract: CIMT is increased in adolescents with type 2 diabetes. Poor glycemic control, HOMA, increased C-reactive protein, body mass index, duration of diabetes, and elevated blood pressure are associated with early atherosclerosis in these patients.

Cited by 24 publications

References 23 publications

Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

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